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Nicardipine Hcl Vial — prescription drug image

Nicardipine Hcl

niCARdipine HCl 10ML of 2.5MG/ML

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What is Nicardipine Hcl?

Nicardipine HCl is a calcium channel blocker used primarily for the treatment of hypertension and angina. It works by relaxing the muscles of your heart and blood vessels, thus improving blood flow and reducing blood pressure. Nicardipine HCl is often administered orally or intravenously, depending on the clinical requirement and severity of the condition.

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What is Nicardipine Hcl ?

Nicardipine HCl is a calcium channel blocker used primarily for the treatment of hypertension and angina. It works by relaxing the muscles of your heart and blood vessels, thus improving blood flow and reducing blood pressure. Nicardipine HCl is often administered orally or intravenously, depending on the clinical requirement and severity of the condition.
  • Wheezing or trouble breathing
  • Unusual tiredness or weakness
  • Fast, irregular, or pounding heartbeat
  • Skin rash
  • Chest pain (may be related to your disease and not a side effect)
  • Wheezing or trouble breathing
  • Unusual tiredness or weakness
  • Do not stop using this medicine suddenly without asking your doctor. You may need to use less and less before stopping it completely.
  • This medicine may make you dizzy or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart failure, stomach problems, liver disease, or kidney disease.
What is nicardipine HCl used for?
Oral nicardipine HCl capsules (immediate-release and extended-release/SR) are used to manage chronic stable angina and to treat high blood pressure. The IV injection form is indicated for the short-term treatment of hypertension when oral therapy isn't feasible or not desirable.
Is nicardipine the same as Cardene?
Yes. Nicardipine hydrochloride is the same medication that was sold under the brand names Cardene, Cardene SR, and Cardene I.V. All of those brand versions have since been discontinued in the US, so today the drug is available only as a generic.
What are the common side effects of nicardipine?
Common side effects include headache, dizziness, flushing, swelling in the legs or feet, heart palpitations, and nausea. The IV form can also cause reactions at the injection or infusion site. Talk to your doctor or pharmacist about any side effects you experience.
Can you suddenly stop taking nicardipine?
No, you should not stop taking nicardipine abruptly without medical guidance. Stopping suddenly can cause a rebound increase in chest pain. If you need to stop or change your dose, talk with your provider first.
How is nicardipine different from other calcium channel blockers like amlodipine?
Nicardipine and amlodipine are both dihydropyridine calcium channel blockers that work by relaxing blood vessels, but nicardipine is also available as an IV injection for short-term treatment of hypertension when oral therapy isn't feasible, a form amlodipine does not have. Dosing, duration of action, and specific approved uses differ between the two, so your prescriber will choose based on your individual situation.
How much does Nicardipine Hcl cost without insurance?
The price of Nicardipine Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Nicardipine Hcl?
Common side effects of Nicardipine Hcl may include: Wheezing or trouble breathing, Unusual tiredness or weakness, Fast, irregular, or pounding heartbeat, Skin rash, Chest pain (may be related to your disease and not a side effect). This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Nicardipine Hcl?
Generic versions may be available for Nicardipine Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Nicardipine Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Nicardipine Hcl?
The cheapest pharmacy for Nicardipine Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Nicardipine Hcl near you.

Nicardipine Hcl Coupons & Prices

niCARdipine HCl 10ML of 2.5MG/ML

Prescriptions & Refills
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Nicardipine Hcl Vial — prescription drug image
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Nicardipine Hcl 10ml of 2.5mg/ml (1)
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Nicardipine HCl is the generic form of the discontinued brand-name drug Cardene, a calcium channel blocker prescribed for chronic stable angina and high blood pressure, with an IV form used for short-term treatment of hypertension when oral therapy isn't feasible or desirable. Because all brand versions are gone from the US market, every prescription filled today is the generic, and cash prices for nicardipine HCl can vary widely from one pharmacy to the next. Enter your ZIP above to compare a nicardipine HCl coupon across pharmacies near you and find the lowest price today.

What is nicardipine HCl and how does it work?

Nicardipine hydrochloride is a calcium channel blocker in the dihydropyridine class. Oral capsules, both immediate-release and extended-release (SR), are used to manage chronic stable angina and to treat high blood pressure. A separate IV injection form is used for the short-term treatment of hypertension when oral therapy isn't feasible or not desirable.

The drug works by relaxing and widening blood vessels, which lowers blood pressure and reduces the heart's workload. Nicardipine HCl was originally sold under the brand name Cardene (with Cardene SR and Cardene I.V. versions), but all brand versions have since been discontinued in the US; today it's available only as a generic.

Comparing nicardipine HCl prices

Because nicardipine HCl is generic-only, pricing depends entirely on which pharmacy you use, and cash prices for the same medication can differ significantly from one pharmacy to another in the same area. Rx.com compares prices across more than 60,000 pharmacies nationwide, so you can find where your prescription costs the least before you fill it. Enter your ZIP code above to see today's price at pharmacies near you.

If cost is a concern, ask your pharmacist or provider whether the immediate-release capsule, the extended-release (SR) capsule, or a different calcium channel blocker best fits your treatment plan and budget, since not every form or alternative is priced the same.

Nicardipine vs. other calcium channel blockers

Nicardipine is one of several calcium channel blockers used to treat high blood pressure and/or angina. Other dihydropyridine options include amlodipine, nifedipine, and felodipine, while diltiazem and verapamil belong to a different class (non-dihydropyridine) and also slow heart rate. Which one is right for you depends on your specific diagnosis, other medications, and how your body responds, so this is a decision for you and your prescriber, not something to switch on your own.

Safety information

Nicardipine HCl does not carry an FDA boxed warning, but it is contraindicated in patients with advanced aortic stenosis and should not be prescribed to people with this condition. In these patients, lowering the pressure the heart pumps against can reduce diastolic blood pressure and worsen, rather than improve, the heart muscle's oxygen balance. Separately, in patients for whom nicardipine is appropriate, it can still cause symptomatic low blood pressure, particularly if the dose is increased quickly. In some patients with coronary artery disease, angina can worsen or a heart attack can occur when starting the drug or increasing the dose. Common side effects include headache, dizziness, flushing, swelling in the legs or feet, heart palpitations, and nausea. The IV form requires continuous blood pressure and heart rate monitoring and carries a risk of reactions at the infusion site.

Do not stop taking nicardipine HCl abruptly without talking to your provider, since stopping suddenly can cause a rebound increase in chest pain. Use caution with liver problems, heart failure, or if you're also taking a beta-blocker or other blood pressure medication, and be aware that grapefruit juice can raise nicardipine levels in your body. This is general information, not medical advice; talk to your doctor or pharmacist about your specific situation.

Sources & accuracy

This Nicardipine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Nicardipine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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