Nitrofurantoin
Nitrofurantoin
What is Nitrofurantoin?
Nitrofurantoin Monohydrate/Macrocrystals (Macrobid) is a prescription antibiotic used to treat uncomplicated urinary tract infections (UTIs) caused by susceptible bacteria. Its dual formulation provides sustained antibacterial activity to help relieve symptoms such as painful urination, frequent urination, and urinary urgency.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Cough, fever, chills, weakness, chest pain
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Do not breastfeed in babies younger than 1 month of age or have G6PD deficiency.
- Tell your doctor if you have kidney disease, liver disease, lung disease, anemia, diabetes, a mineral imbalance in the blood, vitamin B deficiency, or a blood condition called G6PD deficiency.
- This medicine may cause the following problems:Lung problems, including pneumonitis or pulmonary fibrosisLiver problemsNerve problems, including peripheral neuropathyBlood problems, including hemolytic anemia
- This medicine may cause your urine to become brown-colored. This is normal and will not affect how the medicine works.
Prescription savings · · · ·
What is Nitrofurantoin ?
Nitrofurantoin Monohydrate/Macrocrystals (Macrobid) is a prescription antibiotic used to treat uncomplicated urinary tract infections (UTIs) caused by susceptible bacteria. Its dual formulation provides sustained antibacterial activity to help relieve symptoms such as painful urination, frequent urination, and urinary urgency.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Cough, fever, chills, weakness, chest pain
- Dark urine, pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Trouble breathing, tiredness, uneven heartbeat
- Severe and watery diarrhea that may contain blood
- Yellowing of your skin or the whites of your eyes.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Do not breastfeed in babies younger than 1 month of age or have G6PD deficiency.
- Tell your doctor if you have kidney disease, liver disease, lung disease, anemia, diabetes, a mineral imbalance in the blood, vitamin B deficiency, or a blood condition called G6PD deficiency.
- This medicine may cause the following problems:Lung problems, including pneumonitis or pulmonary fibrosisLiver problemsNerve problems, including peripheral neuropathyBlood problems, including hemolytic anemia
- This medicine may cause your urine to become brown-colored. This is normal and will not affect how the medicine works.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Call your doctor if your symptoms do not improve or if they get worse.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Nitrofurantoin Coupons & Prices
Nitrofurantoin
Weight-loss medication, prescribed online
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Looking for a nitrofurantoin coupon? Nitrofurantoin is a widely used generic antibiotic for uncomplicated urinary tract infections, sold under brand names like Macrobid and Macrodantin. As a generic it is already one of the lower-cost UTI treatments, but the cash price can vary a lot from one pharmacy to the next, so comparing before you fill genuinely matters. Enter your ZIP above to see today's price and a free Rx.com discount that you can use at the pharmacy counter, checked across more than 60,000 U.S. pharmacies.
What is nitrofurantoin and how does it work?
Nitrofurantoin is a nitrofuran antibacterial, a type of urinary anti-infective. After you take it, the drug concentrates in your urine, where it damages the bacteria most often responsible for bladder infections, including E. coli, Enterococcus, and Staphylococcus. It is FDA-approved to treat acute, uncomplicated urinary tract infections (cystitis), and lower-dose formulations are also approved to help prevent them. It is available as an affordable generic and under the brand names Macrobid, Macrodantin, and Furadantin.
Because it works by building up in the urine rather than in the bloodstream and tissues, nitrofurantoin is not effective for kidney infections (pyelonephritis) or for infections anywhere outside the urinary tract. It is commonly chosen as a first-line option for simple lower UTIs and is sometimes used for ongoing UTI prevention. Your prescriber decides whether it is the right fit for your infection.
Nitrofurantoin cost and how to save without insurance
Nitrofurantoin is a generic, so it is usually far cheaper than brand-name antibiotics, but "generic" does not mean the price is the same everywhere. The cash price for the same prescription can differ widely between a large chain, a grocery pharmacy, and an independent down the street, which is exactly why comparing pays off. If you are paying without insurance, a discount can bring the counter price down meaningfully.
There is no manufacturer savings card for nitrofurantoin. Instead, enter your ZIP above to see today's price and print or show a free Rx.com coupon, which Rx.com compares across more than 60,000 pharmacies to find a low nearby price. The coupon is a cash-discount option and does not use your insurance, so it is worth checking against any insurance copay to see which is lower for you.
Alternatives and related antibiotics
Nitrofurantoin is one of several antibiotics prescribers use for urinary tract infections, and the right choice depends on your infection, allergies, kidney function, and local bacterial resistance patterns. Only your provider can determine which is appropriate for you.
Related options and brand equivalents you can compare on Rx.com include:
- Macrobid and Macrodantin - brand versions of nitrofurantoin
- Sulfamethoxazole-trimethoprim - a common combination antibiotic for UTIs
- Cephalexin - a cephalosporin antibiotic
- Ciprofloxacin - a fluoroquinolone
- Fosfomycin - a single-dose UTI option
Safety and side effects
The most common side effects are usually mild and include nausea, headache, and gas (flatulence). Nitrofurantoin also often turns the urine a harmless dark yellow or brown color, which is expected and not a cause for concern. This information is educational and not medical advice, so review your full history with your provider or pharmacist.
Nitrofurantoin is not right for everyone. It should not be used by people with significant kidney impairment (where it works less well and toxicity rises), by pregnant patients at 38 to 42 weeks or at the onset of labor, or by infants under one month old, because of the risk of hemolytic anemia. Less common but serious reactions can affect the lungs (including pulmonary fibrosis with long-term use), the liver (hepatitis and, rarely, liver damage), and the nerves (peripheral neuropathy, more likely with kidney problems, diabetes, anemia, electrolyte imbalance, or vitamin B deficiency). People with G6PD deficiency have a higher risk of hemolytic anemia. Optic neuritis and C. difficile-associated diarrhea have also been reported. Contact your provider promptly about new breathing trouble, numbness or tingling, yellowing of the skin or eyes, or severe or ongoing diarrhea.
This Nitrofurantoin information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Nitrofurantoin on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.