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Petrolatum

Petrolatum 454GM of 42%

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What is Petrolatum?

Petrolatum is a topical ointment primarily used to moisturize and protect dry skin. It acts as a barrier, preventing moisture loss while soothing minor skin irritations. Commonly found in skincare products, petrolatum is easily accessible for prescription online. Discover its benefits at Rx.com, where you can compare costs and access savings cards for your prescriptions.

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What is Petrolatum ?

Petrolatum is a topical ointment primarily used to moisturize and protect dry skin. It acts as a barrier, preventing moisture loss while soothing minor skin irritations. Commonly found in skincare products, petrolatum is easily accessible for prescription online. Discover its benefits at Rx.com, where you can compare costs and access savings cards for your prescriptions.
  • Rarely, skin irritation
  • Possibly pore clogging if used extensively on the face, especially in acne-prone areas
  • Avoid using on deep or puncture wounds, animal bites, or serious burns without medical advice
  • If condition worsens or does not improve within 7 days, consult a doctor
Is petrolatum the same thing as Vaseline?
Vaseline is a well-known brand name for petroleum jelly, which is essentially the same purified petrolatum used in generic and store-brand skin protectant ointments.
Can petrolatum be used on lips and the face?
Yes, petrolatum-based ointments are commonly used to protect and help relieve chapped or cracked lips and skin. It's generally considered safe for facial use, but avoid getting it in the eyes.
Is petrolatum safe for babies?
Plain white petrolatum is widely used to help protect a baby's skin, including in some diaper-rash routines, but you should check with your pediatrician before using it on broken skin or if a rash isn't improving.
Does petrolatum expire?
Sealed petrolatum products are shelf-stable for a long time, but check the package for a use-by date and discard if the texture, color, or smell changes.
Will petrolatum treat eczema or psoriasis?
Petrolatum can help lock in moisture and support a skin-barrier routine for dry or irritated skin, but it doesn't treat the underlying inflammation of eczema or psoriasis. Talk to your doctor about a full treatment plan for those conditions.
How much does Petrolatum cost without insurance?
The price of Petrolatum without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 28% off retail prices with a free Rx.com coupon.
What are the common side effects of Petrolatum?
Common side effects of Petrolatum may include: Rarely, skin irritation, Possibly pore clogging if used extensively on the face, especially in acne-prone areas. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Petrolatum?
Generic versions may be available for Petrolatum. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Petrolatum on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Petrolatum?
The cheapest pharmacy for Petrolatum depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Petrolatum near you.

Petrolatum Coupons & Prices

Petrolatum 454GM of 42%

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Petrolatum Jar — prescription drug image
Prescription
Petrolatum 454gm of 42% (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Petrolatum prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
100gm of 42% · Jar 100 $11.99 $9.76
454gm of 42% · Jar 454 $36.13 $16.65

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Petrolatum (also sold as white petrolatum, or under brand names like Vaseline) is an over-the-counter skin protectant found in ointments, lip balms, and diaper-rash products. It doesn't require a prescription, but if your doctor has you using a prescription-strength petrolatum-based ointment or a related skin product, enter your ZIP above to see today's price and find a petrolatum coupon at pharmacies near you.

What is petrolatum and how does it work?

Petrolatum is a soft, semi-solid mixture of hydrocarbons refined for medical use. It doesn't absorb into the skin or treat any underlying condition; instead it sits on the surface and forms an occlusive barrier that seals in moisture and shields skin from air, wind, and friction. Under the FDA's over-the-counter skin protectant rules, petrolatum is recognized as safe and effective for temporarily protecting minor cuts, scrapes, and burns, and for temporarily protecting and helping relieve chapped or cracked skin and lips.

Saving on petrolatum products

Plain petrolatum is inexpensive and widely available without a prescription at any drug store, grocery store, or big-box retailer, usually store-brand and name-brand versions side by side. Prices vary by retailer and package size, so it's worth comparing before you buy. If your provider has prescribed a medicated ointment that contains petrolatum as a base, or a specialty skin-barrier product, you can enter your ZIP above to compare pharmacy prices and see whether a coupon lowers the cost.

Petrolatum vs. other skin protectants

  • Petrolatum — pure occlusive barrier, fragrance-free options widely available.
  • Aquaphor — contains petrolatum along with additional ingredients such as lanolin alcohol and glycerin.
  • Dimethicone or zinc-oxide based protectants — often used in diaper-rash and barrier creams as alternative occlusive or protective agents.

All of these work by physically protecting the skin rather than by any drug action, so the right choice usually comes down to texture preference, added ingredients, and where on the body you're using it.

Safety information

Petrolatum is for external use only. Stop use and ask a doctor if the condition worsens, if symptoms last more than seven days, or if a rash or irritation develops. Avoid use in the eyes, and check with a doctor before applying to deep or puncture wounds, animal bites, or serious burns. This is general information, not medical advice — talk to your doctor or pharmacist about the right product for your skin concern.

Sources & accuracy

This Petrolatum information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Petrolatum on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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