Preparation H
Preparation H 26GM of 1-0.25-14.4-15%
What is Preparation H?
Preparation H is an over-the-counter medication primarily used to relieve the discomfort associated with hemorrhoids. It contains active ingredients such as phenylephrine, which reduces swelling, and pramoxine, which alleviates pain and itching. Preparation H is available in various forms, including creams, gels, and suppositories, making it versatile for different needs.Side Effects
- Mild pain or irritation
- Burning sensation
Warnings
- Do not use if you have an allergic reaction to the components of the product.
- Consult a doctor if symptoms do not improve within 7 days.
Prescription savings · · · ·
What is Preparation H ?
Preparation H is an over-the-counter medication primarily used to relieve the discomfort associated with hemorrhoids. It contains active ingredients such as phenylephrine, which reduces swelling, and pramoxine, which alleviates pain and itching. Preparation H is available in various forms, including creams, gels, and suppositories, making it versatile for different needs.- Mild pain or irritation
- Burning sensation
- Do not use if you have an allergic reaction to the components of the product.
- Consult a doctor if symptoms do not improve within 7 days.
Preparation H Coupons & Prices
Preparation H 26GM of 1-0.25-14.4-15%
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Preparation H is an over-the-counter hemorrhoid treatment sold in several formulas (Original, Maximum Strength, Anti-Itch, Cooling Gel, and Medicated Wipes), and you don't need a prescription to buy it, so a preparation-h coupon can still help you compare pharmacy prices before you check out. Because store-brand versions of the same active ingredients exist, entering your ZIP above lets you see today's price at nearby pharmacies and decide whether the brand name or a generic makes more sense for you.
What Preparation H is and how it works
Preparation H isn't a single formula but a line of topical, external-use products for hemorrhoid symptoms. The Original line combines phenylephrine HCl, a vasoconstrictor that temporarily shrinks hemorrhoidal tissue, with protectants such as mineral oil and petrolatum that soothe irritated skin. Maximum Strength adds pramoxine HCl, a local anesthetic, to that phenylephrine base for extra numbing relief. The Anti-Itch line uses hydrocortisone (a topical corticosteroid) alone, aimed specifically at itching rather than swelling.
All of these are regulated under an FDA OTC monograph for anorectal products, meaning they're approved for temporary relief of itching, burning, discomfort, irritation, and swelling from hemorrhoids or minor anal fissures. They aren't intended to treat any internal or systemic condition.
Comparing pharmacy prices and generic options
Because Preparation H is sold over the counter, prices can vary quite a bit from one pharmacy to the next, and store-brand or generic versions with the same active ingredients (phenylephrine, pramoxine, or hydrocortisone) are generally available. Since this isn't a prescription product, there's no manufacturer copay card to apply here, but it's still worth entering your ZIP code above to compare what different nearby pharmacies charge for the brand name versus a generic equivalent before you buy.
Alternatives and related treatments
Depending on which symptom bothers you most, other OTC options treat similar hemorrhoid or anorectal complaints. Plain hydrocortisone cream can address itching on its own, witch-hazel pads are a common astringent alternative for soothing irritated tissue, and Anusol is another OTC anorectal product formulated for similar symptoms. If numbing is the priority, topical lidocaine products are another local anesthetic option. None of these are direct substitutes for every Preparation H variant, so match the active ingredient to the symptom you're treating, or ask a pharmacist which fits your situation.
Safety and when to see a doctor
Preparation H products are for external and perianal use only and should not contact the eyes. The label advises stopping and consulting a doctor if you notice rectal bleeding, your symptoms don't improve within 7 days, or you need it for longer than that without medical guidance. Hydrocortisone-containing formulas (Anti-Itch) shouldn't be used for prolonged periods because of the risk of skin thinning. Anyone with heart disease, high blood pressure, or thyroid disease, or who takes an MAOI, should check with a doctor before using phenylephrine-containing formulas, since phenylephrine is a vasoconstrictor. Keep it out of reach of children, and this information isn't a substitute for talking with your doctor or pharmacist about your specific situation.
This Preparation H information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Preparation H on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.