Raloxifene Hcl
Raloxifene HCl 60MG
What is Raloxifene Hcl?
Raloxifene HCl is a selective estrogen receptor modulator (SERM) primarily used in the prevention and treatment of osteoporosis in postmenopausal women. It mimics the effects of estrogen on bone density and lipid metabolism while antagonizing estrogen's effects in breast and uterine tissues, which helps reduce the risk of estrogen-dependent cancers. Raloxifene is also shown to reduce the incidence of vertebral fractures.Side Effects
- Unusual vaginal pain, bleeding, or discharge.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, or painful urination.
Warnings
- Although it is unlikely that a postmenopausal woman might become pregnant, you should know that using this medicine while you are pregnant could harm the unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you have congestive heart failure, cancer, liver disease, kidney disease, high cholesterol or triglycerides in your blood, or a history of breast cancer. Also tell your doctor if you have a history of stroke, transient ischemic attacks (TIA), heart rhythm problems, or high blood pressure.
- Raloxifene may increase your risk of having blood clots, especially during the first 4 months that you are using the medicine. Avoid sitting for long periods of time (such as during a long car trip); get up and walk around often.
- Raloxifene does not act like an estrogen to stimulate the uterus or breast. If you have vaginal bleeding, breast pain, or breast enlargement while you are using this medicine, check with your doctor right away.
- If you will be inactive for several days (such as recovering from surgery), talk with your doctor. You may need to stop taking this medicine for awhile.
Prescription savings · · · ·
What is Raloxifene Hcl ?
Raloxifene HCl is a selective estrogen receptor modulator (SERM) primarily used in the prevention and treatment of osteoporosis in postmenopausal women. It mimics the effects of estrogen on bone density and lipid metabolism while antagonizing estrogen's effects in breast and uterine tissues, which helps reduce the risk of estrogen-dependent cancers. Raloxifene is also shown to reduce the incidence of vertebral fractures.- Unusual vaginal pain, bleeding, or discharge.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, or painful urination.
- Chest pain, shortness of breath, or coughing up blood.
- Fever, chills, cough, runny or stuffy nose, sore throat, and body aches.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Pain, redness, or swelling in your leg, especially the lower leg (calf).
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your hands, ankles, or feet.
- Although it is unlikely that a postmenopausal woman might become pregnant, you should know that using this medicine while you are pregnant could harm the unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you have congestive heart failure, cancer, liver disease, kidney disease, high cholesterol or triglycerides in your blood, or a history of breast cancer. Also tell your doctor if you have a history of stroke, transient ischemic attacks (TIA), heart rhythm problems, or high blood pressure.
- Raloxifene may increase your risk of having blood clots, especially during the first 4 months that you are using the medicine. Avoid sitting for long periods of time (such as during a long car trip); get up and walk around often.
- Raloxifene does not act like an estrogen to stimulate the uterus or breast. If you have vaginal bleeding, breast pain, or breast enlargement while you are using this medicine, check with your doctor right away.
- If you will be inactive for several days (such as recovering from surgery), talk with your doctor. You may need to stop taking this medicine for awhile.
- You can help this medicine work better by eating a balanced diet, exercising regularly, and avoiding cigarettes and alcohol. Make sure you get enough calcium and vitamin D every day, through either food or supplements. Talk with your doctor about specific ways you can improve your situation.
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your hands, ankles, or feet.
- Unusual vaginal pain, bleeding, or discharge.
Raloxifene Hcl Coupons & Prices
Raloxifene HCl 60MG
Looking for a raloxifene HCl coupon? Raloxifene hydrochloride is the generic form of Evista, and because it's available as a generic, prices for the same tablet can still swing a lot from one pharmacy to the next. Rx.com compares prices at more than 60,000 U.S. pharmacies, so before you fill your prescription, enter your ZIP above to see today's price near you and find the pharmacy charging the least for your exact dose.
What is raloxifene HCl and how does it work?
Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM). In postmenopausal women, it's FDA-approved for the treatment and prevention of osteoporosis, and separately to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are at high risk for invasive breast cancer. Raloxifene is not approved for men or premenopausal women, and it is not used for hot flashes or other menopausal symptoms — it can actually make hot flashes worse.
Raloxifene HCl cost: why comparing pharmacies matters
Raloxifene is sold as a generic, and its price can still vary widely by pharmacy, quantity, and your location — a coupon or discount doesn't always guarantee the lowest total price at every store. Rather than guessing, it's worth comparing what different pharmacies actually charge for the same prescription. Enter your ZIP code above to see current prices across pharmacies near you, and check with your insurance plan or pharmacist about which option costs you the least out of pocket.
Raloxifene vs. Evista and other options
Raloxifene HCl is the generic equivalent of the brand-name drug Evista — same active ingredient, same approved uses. For osteoporosis specifically, your provider may also discuss other classes of medication, including bisphosphonates such as alendronate (brand name Fosamax) or ibandronate, which work differently than a SERM. Tamoxifen is another SERM, but it's used for different indications than raloxifene. Which option is right depends on your bone density results, personal and family health history, and other medications you take — this is a conversation to have with your provider, not a decision to make from a price comparison alone.
Raloxifene safety information
Raloxifene carries boxed warnings for an increased risk of blood clots — including deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis. Your provider will typically have you stop taking it at least 72 hours before, and during, any period of prolonged immobility (such as a long trip or surgical recovery). Raloxifene is not approved to reduce the risk of coronary heart disease; in a clinical trial of women with or at increased risk for heart disease, there was no significant difference in overall stroke rates between raloxifene and placebo, but women taking raloxifene had a significantly increased risk of dying if they did have a stroke — a finding serious enough that it's also called out in raloxifene's boxed warning. It should not be used by women who have or have had a blood clot, or who are or could become pregnant.
This is general information, not medical advice. Talk with your doctor or pharmacist about whether raloxifene is right for you and about any other conditions or medications that could affect its safety.
This Raloxifene Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Raloxifene Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.