Rexulti Coupons & Prices

If you are looking for a Rexulti coupon, you can use the free Rx.com discount card to compare cash prices for brexpiprazole tablets at pharmacies near you. Rexulti (brexpiprazole) is a brand-name atypical antipsychotic tablet with no cash-price consistency from one pharmacy to the next, so what you pay can vary widely across town. Enter your ZIP code above to see today's price for your strength and quantity, then show the coupon at the pharmacy counter. The Rx.com coupon is a cash-price discount, not insurance, and it can be used whether or not you have coverage.

What is Rexulti and how does it work?

Rexulti is the brand name for brexpiprazole, an atypical (second-generation) antipsychotic sometimes described as a serotonin-dopamine activity modulator. It acts as a partial agonist at serotonin 5-HT1A and dopamine D2 receptors, and as an antagonist at serotonin 5-HT2A and alpha-1B/2C adrenergic receptors. In plain terms, rather than simply blocking dopamine, it works to modulate signaling at several receptor types at once.

Rexulti tablets are FDA-approved for three uses in the United States: as an add-on to an antidepressant for major depressive disorder (MDD) in adults; for schizophrenia in adults and in children ages 13 and older; and for agitation associated with dementia due to Alzheimer's disease. It is not approved as an as-needed ("prn") treatment for that agitation, and it is not approved for dementia-related psychosis without agitation. It is also not approved for MDD in children. Brexpiprazole has been studied as add-on therapy for PTSD alongside sertraline, and it is sometimes discussed for other conditions, but those are not FDA-approved uses and are not something to pursue on your own. Rexulti comes as 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg oral tablets.

Rexulti cost: manufacturer savings card vs. the Rx.com cash coupon

Two very different discounts exist for Rexulti, and knowing which one applies to you saves a lot of frustration at the counter. The manufacturer, Otsuka, runs an official Rexulti savings program described on the Rexulti brand website. Like most brand savings cards, it is generally limited to people with commercial (private) insurance, and eligibility rules, benefit amounts, and expiration terms vary and change, so read the current terms on the manufacturer's own site before you count on it. People with Medicare, Medicaid, TRICARE, or other government coverage are typically excluded from these programs, and the uninsured often are too. Manufacturers also sometimes offer patient assistance for people who qualify on income grounds, which is worth asking the prescriber's office or the manufacturer about.

The Rx.com coupon fills the gaps. It is a cash-price discount, so it works if you are uninsured, if you have Medicare and the manufacturer card is off the table, or if the savings card is simply declined at the register. You cannot combine a cash coupon with your insurance on the same fill, but you can ask the pharmacist to run it both ways and use whichever is lower. Cash prices for Rexulti differ meaningfully from pharmacy to pharmacy, so it is worth comparing rather than assuming. Enter your ZIP above to see today's price for your strength and quantity.

Is there a generic Rexulti, and what are the alternatives?

Generic availability for brexpiprazole in the US is not something we can confirm here, and it can change; ask your pharmacist whether a substitutable generic brexpiprazole is stocked and what it would cost you cash. If one is available to you, it is usually the single biggest lever on price for a brand-name medicine like this one.

Other atypical antipsychotics are prescribed for overlapping conditions, and several have long-available generics, which often makes their cash price a different conversation. Only your prescriber can decide whether a switch makes sense for you, since these drugs differ in side effects, dosing, and which conditions they are approved to treat. Ones you may hear about include:

• Abilify and its generic, aripiprazole — the closest relative to brexpiprazole in how it works
• Vraylar (cariprazine)
• Latuda (lurasidone)
• Seroquel (quetiapine)

Never stop or swap an antipsychotic on your own. If cost is the reason you are considering a change, tell your prescriber directly, since they can often pick an equally suitable option that is easier to afford.

Rexulti safety: what to know before you fill

Rexulti carries a two-part boxed warning, the FDA's most serious label warning. First, elderly patients with dementia-related psychosis who are treated with antipsychotics face an increased risk of death, and Rexulti is not approved for dementia-related psychosis without agitation associated with Alzheimer's disease. Second, antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults; anyone taking Rexulti should be watched closely for worsening mood or new suicidal thoughts, especially in the first few months and after any dose change. Safety and effectiveness have not been established in children with MDD.

The label also warns about strokes and other cerebrovascular reactions in elderly patients with dementia; neuroleptic malignant syndrome, which can be fatal; tardive dyskinesia, which may be permanent; metabolic changes including high blood sugar or new diabetes, high cholesterol and triglycerides, and weight gain; compulsive behaviors such as pathological gambling, eating, shopping, or sexual urges; low white blood cell counts; low blood pressure on standing, with fainting and falls; seizures; trouble regulating body temperature; swallowing problems; and impaired thinking or movement, so use caution with driving or machinery. The most common side effects are akathisia (a restless urge to move) and weight gain. Doses may need adjusting if you take strong CYP2D6 or CYP3A4 inhibitors or inducers, or if you are a CYP2D6 poor metabolizer, so give your pharmacist your full medication list. This page is general information, not medical advice; talk with your prescriber or pharmacist about your own situation.