503A Pharmacy Semaglutide Prices in 2026: What Compounded Semaglutide Costs and What’s Included
Compounded semaglutide from a 503A pharmacy can be priced per vial, per milligram or as a prepaid bundle, with shipping, supplies and the prescription itself often billed separately. Here is how 503A pricing works, what to add up before you order, and how Rx.com’s all-in price compares.
A 503A pharmacy is a state-licensed compounding pharmacy that prepares semaglutide for one patient at a time from a valid prescription. Pharmacies price it per vial, per milligram or as a prepaid bundle, and the pharmacy price usually does not include the prescriber visit, and may not include syringes or cold-packed shipping. To compare fairly, add those costs and price it at the dose you will reach, not the starter dose. Through the Rx.com weight loss program, compounded semaglutide is $99 a month with a 12-month plan, with the provider visit, medication at every dose, supplies and shipping included.
- 503A pharmacies compound medication for an individual patient based on a prescription, and compounded drugs are not FDA-approved. (fda.gov)
- Since FDA declared the semaglutide shortage resolved in February 2025, 503A pharmacies may no longer make copies of the commercial products, but may still compound semaglutide for a patient whose prescriber determines they need a change from the commercial product. (fda.gov)
- Semaglutide doses rise every 4 weeks from 0.25 mg to a 2.4 mg weekly maintenance dose, so per-milligram pricing climbs as you titrate. (dailymed.nlm.nih.gov)
- Compounded semaglutide ships refrigerated, and each vial carries a beyond-use date set by the pharmacy.
- Rx.com’s compounded semaglutide is $99 a month with a 12-month plan, the same at every dose, with the visit and shipping included.
What a 503A Pharmacy Is
A 503A pharmacy is a state-licensed pharmacy that compounds medication for an individual patient based on a prescription, under section 503A of the Federal Food, Drug, and Cosmetic Act. It is regulated mainly by state boards of pharmacy. A 503B outsourcing facility is different: it registers with FDA, can make larger batches and follows federal manufacturing standards. (fda.gov)
503A compounded semaglutide is a patient-specific semaglutide injection prepared by a state-licensed compounding pharmacy from a prescription. It is usually supplied in refrigerated multi-dose vials, is not FDA-approved, and is not the same product as Wegovy or Ozempic.
How 503A Pharmacies Price Semaglutide
There is no standard price list: each pharmacy sets its own, and prices change often. The common models are:
| Pricing model | How it works | What to watch |
|---|---|---|
| Per vial | A set price for a vial of a given strength and volume | Higher doses need more vials, so the monthly cost rises |
| Per milligram | Price scales with the total semaglutide supplied | The cost at 2.4 mg a week is about ten times the cost at 0.25 mg |
| Prepaid bundle | Several months paid up front | Check whether the bundle covers your maintenance dose or only the early months |
Call the pharmacy before you send a prescription to confirm the current price, whether it ships to your state, and how much it sends per order.
Price It at Your Dose
Because the weekly dose climbs, any per-vial or per-mg price has to be multiplied out at the dose you will actually use. This table shows roughly how much semaglutide a month at each step uses.
| Weekly dose | Semaglutide per month (about) | Rx.com price per month (12-month plan) |
|---|---|---|
| 0.25 mg | 1.1 mg | $99 |
| 0.5 mg | 2.2 mg | $99 |
| 1 mg | 4.3 mg | $99 |
| 1.7 mg | 7.4 mg | $99 |
| 2.4 mg | 10.4 mg | $99 |
Monthly amounts are weekly dose × 52 ÷ 12. To compare a pharmacy quote, multiply its price per mg by the monthly amount at your dose, then add the extras below. The full schedule is in our semaglutide dosage chart.
What to Add to the Pharmacy Price
- The prescription: A 503A pharmacy needs a prescription from a licensed prescriber. If you do not already have one, the visit and any follow-ups are a separate cost.
- Cold-packed shipping: Semaglutide vials ship refrigerated, often with a per-order shipping charge.
- Supplies: Syringes and alcohol pads may or may not be included.
- Labs: Ask your prescriber whether baseline labs are needed and who pays for them.
- Order size and beyond-use dates: Each vial has a beyond-use date. Ordering more than you can use before that date means paying for medication you discard.
⚠️ Research-use “semaglutide” is not a 503A product
Vials sold online as “research use only” are not prescriptions, are not made for human use, and have no pharmacy standards behind them. Only use semaglutide dispensed by a licensed pharmacy on a prescription.
How Rx.com’s Price Compares
The Rx.com weight loss program charges one flat price at every dose: compounded semaglutide is $99 a month with a 12-month plan. That price includes the online visit with a licensed U.S. provider, the prescription, the medication at whatever dose is prescribed, injection supplies and cold-packed shipping from a licensed U.S. pharmacy. The 12-month plan ships in 3-month installments, and you are not charged for medication if the provider does not approve treatment. Compounded tirzepatide is $149 a month on the same terms.
Which route fits you?
Check the column that fits your situation.
✅ An all-in program fits if
- You do not have a prescription yet
- You want one price that does not change with your dose
- You want the visit, supplies and shipping included
- You want a provider to manage dose increases
🏥 Check other options first if
- Your insurance may cover Wegovy or Ozempic
- You are on Medicare
- You are pregnant, planning pregnancy or breastfeeding
- You have a history of pancreatitis or medullary thyroid cancer
Brand-Name Options and Insurance
If your insurance covers Wegovy or Ozempic, start there. With commercial coverage, the manufacturer savings card can lower your copay. Without coverage, NovoCare Pharmacy sells Wegovy for self-pay at $199 a month for a new patient’s first two fills, then $349 a month (September 2026). Medicare patients should read our Wegovy cost guide. To compare cash prices for a brand prescription at local pharmacies, check Wegovy and Ozempic with a free Rx.com discount card. For the full picture, see our semaglutide price guide.
🚨 When to Contact Your Healthcare Provider
Contact your provider right away if you have any of the following:
- Severe abdominal pain that does not go away, with or without vomiting, which can signal pancreatitis
- Persistent vomiting or diarrhea that leaves you unable to keep fluids down
- A lump or swelling in the neck, hoarseness or trouble swallowing
- Signs of an allergic reaction, such as swelling of the face or throat, or trouble breathing
- Pain in the upper right abdomen, fever or yellowing of the skin, which can signal gallbladder problems
- Redness, warmth or pus at an injection site, which can signal infection
Frequently Asked Questions
How much does 503A compounded semaglutide cost?
It depends on the pharmacy, the pricing model and your dose. Multiply any per-vial or per-mg quote out at your maintenance dose, then add the prescriber visit, supplies and shipping. Through Rx.com, it is $99 a month with a 12-month plan, all of those included.
Can I send my own prescription to a 503A pharmacy?
Many 503A pharmacies fill outside prescriptions for patients in states where they are licensed to ship. Confirm the price, your state and the order size before you send it.
Is compounded semaglutide still legal after the shortage ended?
Since FDA declared the shortage resolved in February 2025, 503A pharmacies may no longer make copies of the commercial products. They may still compound semaglutide for an individual patient when a licensed prescriber determines the patient needs a change from the commercial product.
What is the difference between 503A and 503B?
A 503A pharmacy compounds for individual patients from prescriptions and is overseen mainly by its state board of pharmacy. A 503B outsourcing facility registers with FDA, can produce larger batches and must follow federal manufacturing standards.
Is compounded semaglutide the same as Wegovy?
No. Wegovy is FDA-approved. Compounded semaglutide is not FDA-approved and is prepared for an individual patient by a licensed pharmacy.
References
- U.S. Food and Drug Administration. Compounding laws and policies.
- U.S. Food and Drug Administration. FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize.
- U.S. Food and Drug Administration. FDA’s concerns with unapproved GLP-1 drugs used for weight loss.
- DailyMed. Wegovy (semaglutide) injection prescribing information.
