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Cetirizine Hcl

Cetirizine HCl

What is Cetirizine Hcl?

If you are diagnosed with hay fever or allergies, your doctor might prescribe cetirizine. The drug is also used to treat urticaria (hives) which is an allergic skin reaction.

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What is Cetirizine Hcl ?

If you are diagnosed with hay fever or allergies, your doctor might prescribe cetirizine. The drug is also used to treat urticaria (hives) which is an allergic skin reaction.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Skin or whites of your eyes turn yellow.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Talk with your doctor before taking this medicine if you are pregnant or breast feeding.
  • Check with your doctor before using this medicine if you have kidney disease or liver disease.
Is cetirizine HCl the same as Zyrtec?

Yes. Cetirizine hydrochloride is the active ingredient in Zyrtec. The generic and the brand-name product contain the same medicine and work the same way; the generic is usually less expensive.

Does cetirizine HCl make you drowsy?

It can. Cetirizine is a second-generation antihistamine, so it is much less likely to cause drowsiness than older options like diphenhydramine. But it is not fully non-drowsy — it causes sleepiness in some people and is somewhat more likely to do so than loratadine or fexofenadine. Until you know how it affects you, avoid driving or operating machinery and do not mix it with alcohol.

How long does it take for cetirizine HCl to work?

Cetirizine generally starts relieving allergy symptoms within about an hour and is taken once a day. Effects last through the day, which is why it is dosed once daily. Follow the directions on the label or from your provider.

Can you take cetirizine HCl every day long term?

Many people take cetirizine daily during allergy season or for ongoing hives, and it is intended for regular use. One thing to know: some people who take it daily for a long time have reported severe rebound itching after stopping suddenly. If you plan to use it long term or want to stop, talk with your doctor or pharmacist, especially if you have kidney or liver problems.

What is the difference between cetirizine and loratadine (Claritin)?

Both are once-daily, second-generation antihistamines that treat the same allergy symptoms. The main practical difference is sedation: cetirizine tends to work quickly and is very effective but is somewhat more likely to cause drowsiness, while loratadine (Claritin) is generally less sedating. Some people find one works better for them than the other.

How much does Cetirizine HCl 300 Tablets cost without insurance?
The price of Cetirizine HCl 300 Tablets without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Cetirizine HCl 300 Tablets?
Common side effects of Cetirizine HCl 300 Tablets may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Skin or whites of your eyes turn yellow.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Cetirizine HCl 300 Tablets?
Generic versions may be available for Cetirizine HCl 300 Tablets. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Cetirizine HCl 300 Tablets on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Cetirizine HCl 300 Tablets?
The cheapest pharmacy for Cetirizine HCl 300 Tablets depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Cetirizine HCl 300 Tablets near you.

Cetirizine Hcl Coupons & Prices

Cetirizine HCl

Cetirizine Hcl Bottle — prescription drug image

No Prescription Needed

Cetirizine Hcl is available over the counter — order online or pick up at a pharmacy near you.

Where to Buy Cetirizine Hcl

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Cetirizine Hcl

No prescription needed. Purchase online or in-store.

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Looking for a cetirizine HCl coupon? Cetirizine hydrochloride is the low-cost generic of Zyrtec — a once-daily, second-generation antihistamine that is much less likely to cause drowsiness than older allergy medicines. It relieves sneezing; runny nose; itchy, watery eyes; and the itching and hives of chronic idiopathic urticaria. It is sold over the counter, but a prescription version also exists, and some pharmacies price the same product differently. Enter your ZIP above to see today's price at pharmacies near you and check whether an Rx.com discount coupon beats the shelf price.

What is cetirizine HCl and how does it work?

Cetirizine hydrochloride is a second-generation antihistamine. It works as a selective peripheral H1-receptor antagonist, meaning it blocks the H1 histamine receptors that drive allergy symptoms without heavily crossing into the brain the way older antihistamines do. That is why it is much less likely to cause drowsiness than first-generation options like diphenhydramine — though it can still make some people sleepy, so it is best described as less sedating rather than truly non-drowsy.

It is used to relieve the symptoms of seasonal and perennial (year-round) allergic rhinitis — sneezing; runny nose; itchy or watery eyes; and itching of the nose or throat. It also treats chronic idiopathic urticaria (long-lasting hives of unknown cause), reducing both itching and the number of hives. It is sold over the counter under the brand name Zyrtec (including Zyrtec Allergy), plus many lower-cost store and generic versions. It comes as tablets, chewable tablets, capsules, orally disintegrating tablets, and a syrup.

How to save on cetirizine HCl with an Rx.com coupon

Even though cetirizine HCl is available over the counter, the price can vary a lot from pharmacy to pharmacy, and the generic is often cheaper than the name-brand Zyrtec box. In some cases an over-the-counter product costs less with a discount coupon — or when your doctor writes it as a prescription so it runs through the pharmacy's discount pricing. There is no manufacturer copay or savings card for this generic.

To find the best price, enter your ZIP code above to see today's cost at pharmacies near you and compare it to the Rx.com coupon price. Bring the free coupon to the pharmacy counter and ask them to run it — you do not need insurance to use it.

Cetirizine HCl vs. other allergy medicines

Cetirizine is one of several second-generation antihistamines, and the right choice often comes down to how much drowsiness you can tolerate and how fast you need relief. Cetirizine tends to work quickly and is very effective, but it is somewhat more likely to cause drowsiness than some alternatives.

  • Zyrtec — the brand-name version of the same cetirizine molecule; the generic is usually less expensive.
  • Levocetirizine — a closely related, refined form of cetirizine taken once daily.
  • Loratadine (Claritin) and desloratadine — typically less sedating than cetirizine.
  • Fexofenadine (Allegra) — generally the least sedating option, even at higher doses.

If one antihistamine does not control your symptoms or makes you too sleepy, ask your pharmacist or provider about trying another. This is general information, not medical advice.

Safety and what to know before taking it

Cetirizine HCl has no boxed warning, but it can cause drowsiness or sedation — less than first-generation antihistamines, though more than loratadine or fexofenadine. Until you know how it affects you, avoid driving or operating machinery, and avoid alcohol or other medicines that slow the nervous system. People with significant liver or kidney impairment may need a lower dose or should avoid it, and older adults should use caution.

Some people who take it daily for a long time have reported severe rebound itching (pruritus) after stopping suddenly. Rare allergic reactions, including anaphylaxis, can occur. If you are pregnant, breastfeeding, an older adult, or have kidney or liver disease, talk with your doctor or pharmacist before starting cetirizine. This information is not a substitute for professional medical advice — always follow the label and your provider's guidance.

Sources & accuracy

This Cetirizine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Cetirizine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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