Depo-Estradiol
Depo-Estradiol 5ML of 5MG/ML
What is Depo-Estradiol?
Depo-Estradiol is used to treat certain conditions in men and women including menopausal symptoms, ovarian disorders, and prostate cancer. Depo-Estradiol is a brand-name of estradiol cypionate. The average Depo-Estradiol price is about $144 for one vial, 5 mL of 5 mg/mL intramuscular solution. You can use our Rx.com savings offer to get an average Depo-Estradiol discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Vaginal bleeding or spotting.
- Shortness of breath, cold sweat, and bluish-colored skin.
- Sudden or severe headache, problems with vision, speech, or walking.
Warnings
- It is unlikely that you will become pregnant while you are going through menopause. But, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. If you have recently had an infant, tell your doctor if you are breast feeding.
- Make sure your doctor knows if you have asthma, epilepsy, migraine headaches, heart disease, or kidney disease. Also tell your doctor if you have endometriosis, gallbladder disease, liver disease, lupus, porphyria, or an underactive thyroid.
- This medicine should not be used to treat or prevent heart disease or stroke. In fact, hormone therapy can increase your risk of certain heart or blood vessel problems. Tell your doctor if you have a history of heart attack, stroke, high blood pressure, congestive heart failure, blood clots, or circulation problems.
- Your risk of heart disease or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. If you have diabetes, keep it under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.
- This medicine may also increase your risk of other medical problems, including certain types of cancer. Talk with your doctor about how these risks might affect you.
Prescription savings · · · ·
What is Depo-Estradiol ?
Depo-Estradiol is used to treat certain conditions in men and women including menopausal symptoms, ovarian disorders, and prostate cancer. Depo-Estradiol is a brand-name of estradiol cypionate. The average Depo-Estradiol price is about $144 for one vial, 5 mL of 5 mg/mL intramuscular solution. You can use our Rx.com savings offer to get an average Depo-Estradiol discount of up to 80% off of the retail price at participating pharmacies near you.- Vaginal bleeding or spotting.
- Shortness of breath, cold sweat, and bluish-colored skin.
- Sudden or severe headache, problems with vision, speech, or walking.
- Pain in your lower leg (calf).
- Swelling in your hands, ankles, or feet.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash.
- Breast changes or lumps.
- Chest pain, or coughing up blood.
- Dark-colored urine or pale stools, yellowing of your skin or the whites of your eyes.
- Nausea, vomiting, loss of appetite, pain in your upper stomach.
- Numbness or weakness in your arm or leg, or on one side of your body.
- It is unlikely that you will become pregnant while you are going through menopause. But, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. If you have recently had an infant, tell your doctor if you are breast feeding.
- Make sure your doctor knows if you have asthma, epilepsy, migraine headaches, heart disease, or kidney disease. Also tell your doctor if you have endometriosis, gallbladder disease, liver disease, lupus, porphyria, or an underactive thyroid.
- This medicine should not be used to treat or prevent heart disease or stroke. In fact, hormone therapy can increase your risk of certain heart or blood vessel problems. Tell your doctor if you have a history of heart attack, stroke, high blood pressure, congestive heart failure, blood clots, or circulation problems.
- Your risk of heart disease or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. If you have diabetes, keep it under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.
- This medicine may also increase your risk of other medical problems, including certain types of cancer. Talk with your doctor about how these risks might affect you.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. This medicine may also affect the results of certain medical tests.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Pain in your lower leg (calf).
- Shortness of breath, cold sweat, and bluish-colored skin.
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your hands, ankles, or feet.
- Vaginal bleeding or spotting.
Depo-Estradiol Coupons & Prices
Depo-Estradiol 5ML of 5MG/ML
If you're comparing Depo-Estradiol coupon options, this page covers what the injection is FDA-approved for, how the manufacturer's savings program stacks up against an Rx.com cash coupon, and the generic version that can lower your cost at the pharmacy counter, so you can enter your ZIP above and see today's price before you fill.
What Is Depo-Estradiol and How Does It Work?
Depo-Estradiol (estradiol cypionate injection, USP) is a steroidal estrogen given by intramuscular injection only, made by Pfizer. It's FDA-approved for moderate to severe vasomotor symptoms of menopause (hot flashes, night sweats), typically dosed 1-5 mg every 3-4 weeks, and for hypoestrogenism from hypogonadism, castration, or primary ovarian failure, typically dosed 1.5-2 mg monthly. It is also used off-label as part of feminizing hormone therapy for transgender women, though that is not an FDA-labeled use.
Because it replaces estrogen the body is no longer making enough of, the injection is absorbed slowly from the muscle over the weeks between doses rather than taken daily like a pill.
Manufacturer Savings Card vs. the Rx.com Coupon
Pfizer offers an official savings program for Depo-Estradiol, but manufacturer copay cards like this are generally limited to patients with commercial insurance, and terms (eligibility, exclusions, expiration) can change, so check Pfizer's official site directly for current details rather than relying on a link here. If you're uninsured, on Medicare or Medicaid, or your card is declined at the pharmacy, the manufacturer card typically won't apply.
The Rx.com cash coupon works regardless of insurance status, including for people on Medicare who can't use manufacturer copay assistance. Enter your ZIP above to compare a cash price at pharmacies near you before deciding which option costs less for your situation.
Generic Estradiol Cypionate and Other Estrogen Options
A generic version of estradiol cypionate injection is available and can often be a lower-cost option than the Pfizer-branded Depo-Estradiol; ask your pharmacist whether the generic is in stock and price it alongside the brand. Prices vary by pharmacy, so it's worth comparing.
If an injection every few weeks isn't the right fit, ask your provider about other estrogen replacement forms such as an estradiol tablet or an estradiol patch. Some patients on estrogen therapy who still have a uterus are also prescribed progesterone alongside it. Premarin is a different, conjugated-estrogen product some providers use instead. None of these are automatic substitutes for Depo-Estradiol without your provider's guidance.
Safety Information
Depo-Estradiol carries a boxed warning: estrogen-alone therapy increases the risk of endometrial cancer in women who still have a uterus (a progestin is usually added to reduce this risk), and increases the risk of stroke, deep vein thrombosis, pulmonary embolism, and probable dementia in postmenopausal women 65 and older. Estrogens should not be used to try to prevent heart disease.
It should not be used during pregnancy, with undiagnosed abnormal genital bleeding, known or suspected breast cancer or estrogen-dependent tumors, current or past blood clots (DVT/PE), active arterial clotting disease such as stroke or heart attack, liver disease, or a known allergy to the drug. It's given by intramuscular injection only. This is general information, not medical advice, use the lowest effective dose for the shortest time needed, and talk with your provider about whether Depo-Estradiol is right for you.
This Depo-Estradiol information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Depo-Estradiol on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.