Desoximetasone
Desoximetasone 60GM of 0.25%
What is Desoximetasone?
Topicort is used to relieve certain skin irritations including itching. Desoximetasone is the generic version of Topicort. The average Topicort price is approximately $419 for a supply of 60 g, 0.25% cream. Luckily, you can significantly reduce the Topicort price by using our free Singlecare coupon card at participating local pharmacies.Side Effects
- Severe itching, burning, irritation, redness, swelling, or thinning of the skin
- Weight gain around your neck, upper back, breast, or waist
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have Cushing disease, diabetes, or any type of skin infection.
- This medicine may cause the following problems:Adrenal gland problems, including Cushing syndromeSerious skin reactions, which may occur if you cover the treated skin area or use the spray for a long timeEye or vision problems (including cataracts, glaucoma)
- Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
Prescription savings · · · ·
What is Desoximetasone ?
Topicort is used to relieve certain skin irritations including itching. Desoximetasone is the generic version of Topicort. The average Topicort price is approximately $419 for a supply of 60 g, 0.25% cream. Luckily, you can significantly reduce the Topicort price by using our free Singlecare coupon card at participating local pharmacies.- Severe itching, burning, irritation, redness, swelling, or thinning of the skin
- Weight gain around your neck, upper back, breast, or waist
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blurred vision or other changes in vision, eye pain
- Color changes on the skin, dark freckles, easy bruising, muscle weakness, round or puffy face
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have Cushing disease, diabetes, or any type of skin infection.
- This medicine may cause the following problems:Adrenal gland problems, including Cushing syndromeSerious skin reactions, which may occur if you cover the treated skin area or use the spray for a long timeEye or vision problems (including cataracts, glaucoma)
- Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
- Call your doctor if your symptoms do not improve or if they get worse.
Desoximetasone Coupons & Prices
Desoximetasone 60GM of 0.25%
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Desoximetasone prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 15gm of 0.25% · Tube Of Cream | 60 | $191.99 | $29.07 |
| 15gm of 0.05% · Tube Of Cream | 60 | $265.72 | $96.26 |
| 60gm of 0.25% · Tube Of Cream | 60 | $236.57 | $29.07 |
| 60gm of 0.05% · Tube Of Cream | 60 | $142.69 | $96.26 |
| 100gm of 0.25% · Tube Of Cream | 60 | $136.19 | $29.07 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a desoximetasone coupon? Desoximetasone is a prescription topical corticosteroid (the generic form of Topicort and Topicort LP) used to calm the inflammation, redness, swelling, and itching of steroid-responsive skin conditions. As a generic, it is already one of the lower-cost options in its class, but the cash price can vary widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see the current price and print or text yourself a free discount coupon.
What is desoximetasone and how does it work?
Desoximetasone is a topical corticosteroid applied to the skin. Depending on the formulation and strength it is considered potent to high-potency. It works by reducing the inflammatory response in the skin, which eases redness, swelling, itching, and irritation caused by corticosteroid-responsive skin conditions. It is available as a generic and is sold under the brand names Topicort and Topicort LP.
The cream and ointment (available in 0.05% and 0.25%) and the 0.05% gel are indicated for the inflammatory and itchy manifestations of corticosteroid-responsive dermatoses, and are commonly used for conditions such as eczema (atopic dermatitis), psoriasis, and contact dermatitis. The 0.25% topical spray is FDA-approved specifically for plaque psoriasis in adults 18 years and older. It is for external use only. This is general information, not medical advice; use it exactly as your provider or the label directs.
Desoximetasone cost and coupons without insurance
Because desoximetasone is a generic, it is usually far less expensive than brand-name Topicort, but the cash price is not the same everywhere. The same tube can cost noticeably more at one pharmacy than at another down the street, which is exactly why comparing prices matters. There is no manufacturer copay savings card for generic desoximetasone.
With a free Rx.com discount coupon, you pay the cash price shown, no insurance required. Enter your ZIP above to see today's price for your specific strength and form (cream, ointment, gel, or spray) at pharmacies near you, then show the coupon at the counter. Rx.com compares more than 60,000 pharmacies so you can pick the lowest price without overpaying.
Related topical steroids and alternatives
Desoximetasone is the generic of Topicort. Topical corticosteroids come in a range of potencies, and your provider chooses one based on the condition, the location on the body, and how thick or sensitive the skin is. Other topical steroids your provider may compare it with include:
- Clobetasol and fluocinonide (very high to high potency options)
- Betamethasone and mometasone (mid to high potency)
- Triamcinolone (medium potency)
- Hydrocortisone (low potency, for milder or more delicate areas)
Do not switch products or strengths on your own. Ask your provider or pharmacist which option is right for you, and check the price of each with your ZIP above.
Safety and side effects
Desoximetasone has no boxed warning. The most common side effects are local skin reactions such as burning, itching, irritation, dryness, and folliculitis. Longer-term or improper use, especially over large areas, under occlusion (tight coverings), or on thin skin, can lead to skin thinning (atrophy), stretch marks (striae), visible small blood vessels (telangiectasia), lightening of the skin (hypopigmentation), acne-like eruptions, and perioral dermatitis. Applying too much, over too large an area, or for too long can be absorbed into the body and cause reversible effects such as HPA-axis suppression, Cushing's syndrome, high blood sugar, and sugar in the urine.
Children face a higher risk of absorption and possible growth suppression because they have more skin surface relative to body size; avoid tight diapers or occlusion in children. Topical steroids can also mask or worsen a skin infection. It is for external use only, so keep it away from the eyes and mouth. The spray is flammable, so keep it away from open flame and do not smoke while applying. Use caution in pregnancy and while breastfeeding. This is not a complete list; talk with your provider or pharmacist about your situation and report side effects that concern you.
This Desoximetasone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Desoximetasone on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.