Folbic
Folbic 2.5-25-2MG
What is Folbic?
Folbic is a dietary supplement used to treat vitamin deficiency in the body. Folbic contains a combination of vitamins and folic acid. You can use our Rx.com savings offer to get a Folbic discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Skin tingling, burning, or itching
- Mild diarrhea
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a history of pernicious anemia (not enough vitamin B12).
- Unusual bleeding, bruising, or weakness
Prescription savings · · · ·
What is Folbic ?
Folbic is a dietary supplement used to treat vitamin deficiency in the body. Folbic contains a combination of vitamins and folic acid. You can use our Rx.com savings offer to get a Folbic discount of up to 80% off of the retail price at participating pharmacies near you.- Skin tingling, burning, or itching
- Mild diarrhea
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Unusual bleeding, bruising, or weakness
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a history of pernicious anemia (not enough vitamin B12).
- Unusual bleeding, bruising, or weakness
Folbic Coupons & Prices
Folbic 2.5-25-2MG
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Looking for a Folbic coupon? Folbic is a prescription-marketed vitamin B combination — folic acid, pyridoxine (vitamin B6), and cyanocobalamin (vitamin B12) — used under a doctor's supervision to help lower elevated homocysteine levels. Because it is dispensed at a pharmacy, you can use a free Rx.com cash coupon to bring down the cash price at the register, whether you are uninsured, on Medicare, or your plan does not cover it. Enter your ZIP above to see today's price at pharmacies near you.
What is Folbic and how does it work?
Folbic is a prescription-level combination of folic acid 2.5 mg, pyridoxine (vitamin B6) 25 mg, and cyanocobalamin (vitamin B12) 2 mg. It is marketed for the distinct nutritional requirements of patients being managed by a physician for hyperhomocysteinemia — elevated blood levels of the amino acid homocysteine — particularly those with or at risk for atherosclerotic vascular disease (coronary, peripheral, or cerebral) or vitamin B12 deficiency. It is also commonly used in people with chronic kidney disease or on dialysis, who often have trouble keeping these B vitamins in balance.
These three B vitamins work together in the body's pathways that break down and recycle homocysteine, which is why they are combined in one tablet at prescription strengths. Note that Folbic is marketed as a medical-food / unapproved-drug product rather than a drug with an FDA-approved indication, and its folate strength is well above what is allowed in over-the-counter supplements. It should be used only under a physician's supervision and is not a substitute for a balanced diet.
Folbic cost and savings: coupons, generics, and insurance
There is no manufacturer savings or copay card for Folbic, so the two main ways to lower your cost are your insurance and a cash discount. Manufacturer copay cards, where they exist for brand drugs, are generally limited to people with commercial (employer or marketplace) insurance and exclude Medicare, Medicaid, and the uninsured — with terms that vary. A free Rx.com cash coupon works differently: it is not insurance, so it can be used whether you are uninsured, on Medicare, or in any situation where a plan or card is declined. You simply present it at the pharmacy for a discounted cash price.
Because Folbic is marketed as a medical-food / unapproved-drug product, it is not listed in the FDA's Orange Book and has no FDA therapeutic-equivalence (AB) rating, so your pharmacist cannot automatically swap it for a generic the way they can with an approved brand drug. That said, lower-cost equivalent combination products with the same three ingredients — folic acid / cyanocobalamin / pyridoxine tablets — are sold and typically cost far less than the brand at the same strengths. Filling one of those in place of Folbic usually requires your prescriber to write for it (or is governed by your state's substitution rules), so ask your doctor or pharmacist, then enter your ZIP above to compare the cash price with and without an Rx.com coupon at pharmacies near you.
Folbic alternatives and similar B-vitamin combinations
Several prescription-marketed B-vitamin combinations pair folate with B6 and/or B12 for homocysteine management. Products in this family include Foltx, Folbee, and FaBB, along with other similar combinations such as Virt-Vite and Cerefolin. They differ in the exact vitamins and strengths they contain, so they are not always interchangeable — your prescriber chooses based on your needs.
If your doctor is targeting a single deficiency rather than a combination, the individual ingredients are also available on their own: folic acid, cyanocobalamin (vitamin B12), and pyridoxine (vitamin B6). Each can be priced separately with an Rx.com coupon — enter your ZIP above to compare.
Folbic safety and important warnings
Folbic has no boxed warning, but there are important cautions to review with your provider. It is contraindicated in Leber's optic atrophy, because the cyanocobalamin (B12) component can accelerate irreversible optic-nerve damage in that condition. The pyridoxine (B6) component antagonizes levodopa, so the combination should be avoided in patients taking levodopa without carbidopa. High-dose folic acid can also mask the blood-count signs of vitamin B12 deficiency (pernicious anemia) while nerve damage continues to progress, which is one reason a doctor should oversee its use.
Hypersensitivity reactions to cobalamin are possible. This page is not medical advice — tell your provider about all the medicines and supplements you take, and use Folbic only under physician supervision.
This Folbic information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Folbic on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.