Hyoscyamine Sulfate Er Coupons & Prices

If you're comparing hyoscyamine sulfate ER coupon prices, the good news is that this extended-release antispasmodic already has an FDA-approved generic — but what you pay out of pocket can still swing widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 U.S. pharmacies so you can see where your prescription costs less before you fill it; enter your ZIP code above to see today's price near you.

What Is Hyoscyamine Sulfate ER and How Does It Work?

Hyoscyamine sulfate ER is the extended-release form of hyoscyamine, an anticholinergic (antispasmodic) drug in the belladonna alkaloid class — it's a purified form of the levo-isomer of atropine. It works by blocking acetylcholine at receptors in smooth muscle, which reduces spasm and cuts down on excess gastric and other secretions.

It's FDA-labeled as an add-on therapy for the symptomatic relief of gastrointestinal disorders involving smooth-muscle spasm, such as irritable bowel syndrome (IBS), spastic colitis, and other functional GI disorders, and to help control gastric secretion, visceral spasm, and hypermotility in conditions like peptic ulcer, diverticulitis, cystitis, and biliary colic (used together with morphine or other narcotics for that indication). It's also used for bladder spasm and neurogenic bladder, and as adjunctive therapy in Parkinsonism to help reduce rigidity and control the associated drooling (sialorrhea) and hyperhidrosis. Some clinicians separately prescribe it off-label to help manage excess drooling or respiratory secretions in palliative and hospice care outside of Parkinsonism — ask your provider whether that applies to your situation.

Hyoscyamine Sulfate ER Cost and Coupon Savings

Hyoscyamine sulfate ER is available as a generic, which is typically what a pharmacy fills unless your prescriber specifies a brand such as Levbid, Symax SR, Symax Duotab, Levsinex Timecaps, or Hyomax SR. Even with a generic, cash prices for the same prescription can differ significantly from one pharmacy to the next and can depend on your dose, quantity, and location — which is exactly why comparing before you fill matters.

Rx.com checks pricing across more than 60,000 U.S. pharmacies so you can find a lower price without waiting on insurance to process it. There's no manufacturer savings card available for hyoscyamine sulfate ER, so a pharmacy comparison coupon is generally your best route to a lower cash price. Enter your ZIP above to see today's price at pharmacies near you.

Hyoscyamine Sulfate ER vs. Levsin, Bentyl, and Other Options

Hyoscyamine sulfate ER shares its active ingredient with several other products. Levsin and other immediate-release hyoscyamine sulfate products contain the same drug but are absorbed faster and dosed more often through the day, while the ER version is designed to release more gradually. Donnatal combines hyoscyamine with other belladonna alkaloids and phenobarbital and is a Schedule IV controlled substance because of the phenobarbital — hyoscyamine sulfate ER on its own is not a controlled substance.

For GI spasm specifically, some providers instead prescribe dicyclomine (brand name Bentyl), another anticholinergic antispasmodic used for IBS-related cramping. It works similarly but is a different drug, so switching between them is a decision to make with your provider, not a straight substitution.

Safety Information and Side Effects

Hyoscyamine sulfate ER is an anticholinergic, so it isn't appropriate for everyone. It's contraindicated in glaucoma, obstructive GI disease, paralytic ileus, obstructive uropathy (such as significant BPH with urinary retention), unstable cardiovascular status during acute hemorrhage, severe ulcerative colitis, and myasthenia gravis. It carries no FDA boxed warning.

Common effects include dry mouth, blurred vision, constipation, urinary retention, and a faster heart rate. Because it can reduce sweating, it can also cause anhidrosis and heat prostration — sometimes called "atropine fever," since hyoscyamine and atropine are stereoisomers with equivalent effects — in hot weather or when you have a fever, so take care to avoid overheating. It can also cause drowsiness or confusion, particularly in older adults — it appears on the Beers Criteria list of medications to use with caution in that age group. This isn't a complete list of risks; talk with your doctor or pharmacist about whether it's safe for you.