Lidocaine-Hydrocort (Perianal) Coupons & Prices

Searching for a lidocaine-hydrocortisone perianal cream coupon? This combination prescription cream or gel pairs a numbing agent (lidocaine) with an anti-inflammatory steroid (hydrocortisone) to relieve hemorrhoid and anal-fissure discomfort, and it's sold under a variety of small-manufacturer and compounded brand names rather than one dominant national brand — which means price can swing a lot from pharmacy to pharmacy for the exact same prescription. Rx.com compares pricing across 60,000+ U.S. pharmacies, so enter your ZIP above to see today's price near you before you fill.

What Is Lidocaine-Hydrocortisone Perianal Cream and How Does It Work?

Lidocaine hydrochloride / hydrocortisone (acetate) is a combination topical local anesthetic and topical corticosteroid, applied as a rectal/perianal cream or gel. It's marketed under numerous small-manufacturer or compounded brand names — including Ana-Lex HC, AnaMantle HC, LidaMantle HC, LidaZone HC, LidoCort, Peranex HC, and RectaGel HC — rather than one widely recognized national brand.

The lidocaine component numbs the treated tissue to relieve pain and burning, while the hydrocortisone component reduces inflammation, itching, and soreness. It's FDA-labeled for the perianal/anorectal area and applied topically, typically two to four times daily or as your prescriber directs, for conditions such as hemorrhoids, anal fissures, and pruritus ani (anal itching). It is not approved for oral or ophthalmic (eye) use.

Lidocaine-Hydrocortisone Cost Without Insurance and How to Compare Prices

A generic version of this combination is available, so you don't need one of the specific small-manufacturer brand names above to fill the prescription — your pharmacist can typically fill the generic. Because so many different manufacturers produce this cream or gel and there's no single dominant brand setting a reference price, the cash price without insurance can vary widely from one pharmacy to the next for what is chemically the same product.

That's exactly why comparing matters here: rather than assuming any one pharmacy has the best price, enter your ZIP code above and Rx.com will check pricing for this medication across 60,000+ pharmacies nationwide so you can see today's price near you. There is no manufacturer savings card associated with this combination product.

Related Medications and Alternatives

If your prescriber is considering options, a few related topical medications are sometimes used for overlapping perianal symptoms:

• Hydrocortisone alone — the anti-inflammatory component of this combination, available as a standalone topical without the added anesthetic.
• Lidocaine alone — the numbing component of this combination, available as a standalone topical anesthetic.
• Pramoxine-hydrocortisone — a similar combination product that pairs hydrocortisone with a different topical anesthetic (pramoxine instead of lidocaine).

Whether one of these fits your situation better than the lidocaine-hydrocortisone combination is a decision for your prescriber, based on your specific symptoms and skin condition.

Safety Information

This medication is for external and rectal use only — it should never be swallowed or get in the eyes. Because it numbs the treated area, be careful not to injure the skin while it's numb and you have reduced sensation. Avoid applying it over large areas, on broken or infected skin, or for prolonged periods without follow-up with your provider: excess absorption of lidocaine can affect the heart or nervous system, and prolonged corticosteroid use can thin the skin or, rarely, affect adrenal (HPA-axis) function.

Tell your provider if you have G6PD deficiency, heart disease or an irregular heartbeat (this can interact with certain antiarrhythmic medications), liver or lung disease, an active infection in the perianal area, or if you're pregnant. Stop use and seek medical care if you notice signs of an allergic reaction, persistent burning or irritation, or possible steroid-related side effects. This product does not carry an FDA boxed warning. This information is educational and not a substitute for advice from your doctor or pharmacist.