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Malathion

Malathion 59ML of 0.5%

Prescriptions & Refills
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What is Malathion?

Ovide is indicated for the treatment of lice. Malathion topical is the generic version of Ovide. On average, Ovide is priced at about $171 for a supply of 59 ml, 0.5% topical lotion. You can significantly lower the price of Ovide by using our free Singlecare coupon card at a local participating pharmacy.

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What is Malathion ?

Ovide is indicated for the treatment of lice. Malathion topical is the generic version of Ovide. On average, Ovide is priced at about $171 for a supply of 59 ml, 0.5% topical lotion. You can significantly lower the price of Ovide by using our free Singlecare coupon card at a local participating pharmacy.
  • Pain, reddening, or swelling of the skin
  • Blistering and peeling of the skin
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Call your doctor right away if you have pain or blistering after you use this medicine.
  • Do not use this medicine on your child unless your doctor says it is okay.
  • Wash your scalp and hair immediately if skin irritation occurs. If the irritation goes away after you wash your hair, you may apply the medicine again. If the irritation happens again, check with your doctor.
  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
  • Be careful not get any of this medicine in your eyes. If you do, flush your eyes with water for at least 10 minutes. Check with your doctor if your eyes become irritated or your vision changes.
  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • Call a doctor or poison control center right away if you accidentally swallow this medicine.
How long do you leave malathion lotion on your hair?
Malathion 0.5% lotion is applied to dry hair and left on for 8 to 12 hours before being washed out with shampoo. After rinsing, comb the hair with a fine-toothed nit comb to remove dead lice and eggs. Because the lotion is alcohol-based and flammable, let the hair air dry and keep it away from hair dryers, curling irons, flames, and cigarettes until it is fully dry. Follow the directions your pharmacist and prescriber give you.
Does malathion kill lice eggs (nits)?
Partly. The CDC describes malathion as pediculicidal and partially ovicidal, meaning it kills live lice and some of the eggs (nits), but not necessarily all of them. Do not skip the follow-up: comb the hair with a fine-toothed nit comb after shampooing to remove dead lice and eggs, and check the scalp again in 7 to 9 days. If live lice are still present at that point, a second application may be used, but check with your provider first.
Is malathion lotion available over the counter, or does it need a prescription?
Malathion 0.5% lotion is a prescription-only topical medicine in the U.S. You need a prescription from a doctor, nurse practitioner, or other prescriber to buy it. Over-the-counter lice products such as permethrin 1% cream rinse, pyrethrin shampoos, and topical ivermectin 0.5% lotion do not require a prescription and are usually tried first.
What is the difference between malathion and permethrin for head lice?
Permethrin 1% cream rinse is sold over the counter and is a common first choice, but head lice in many areas have become resistant to it. Malathion 0.5% lotion is prescription-only, is partially ovicidal (it kills some eggs as well as live lice), and is often used when permethrin has not worked. Malathion also has to stay on the hair for 8 to 12 hours and is flammable, while permethrin is rinsed out after about 10 minutes. With either product, comb out the nits and re-check the scalp. Your provider can tell you which is the better fit.
Why is malathion lotion flammable, and what precautions should I take?
The lotion is made with alcohol, which makes it highly flammable. While the lotion is on the hair and until the hair is completely dry, do not smoke and stay away from open flames, stoves, candles, hair dryers, curling irons, flat irons, and other electric heat sources. Never use a hair dryer to dry treated hair. Let the hair air dry instead.
How old does a child have to be to use malathion lotion?
Malathion 0.5% lotion is intended for patients 6 years of age and older, and safety and effectiveness have not been established in children younger than 6. Separately, it is contraindicated in newborns and infants because their scalps absorb more of the medicine, and MedlinePlus notes it should not be used in children under 2 years old. For any child under 6 with head lice, ask the pediatrician which treatment is appropriate rather than using malathion on your own.
How much does Malathion cost without insurance?
The price of Malathion without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Malathion?
Common side effects of Malathion may include: Pain, reddening, or swelling of the skin, Blistering and peeling of the skin, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Malathion?
Generic versions may be available for Malathion. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Malathion on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Malathion?
The cheapest pharmacy for Malathion depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Malathion near you.

Malathion Coupons & Prices

Malathion 59ML of 0.5%

Prescriptions & Refills
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Malathion Bottle — prescription drug image
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Malathion 59ml of 0.5% (1)
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Looking for a malathion coupon? Malathion 0.5% lotion is a prescription topical treatment for head lice, and it is available as a generic (the Ovide brand is no longer marketed in the U.S., but generic malathion lotion from Taro is still available). Cash prices for the same bottle can differ a lot from one pharmacy to the next, so it pays to compare before you fill. Rx.com compares prices at more than 60,000 pharmacies and gives you a free coupon you can show at the counter. Enter your ZIP code above to see today's price near you.

What is malathion lotion and how does it work?

Malathion is a topical pediculicide, which simply means a medicine applied to the hair and scalp to kill head lice (Pediculus humanus capitis). It belongs to a chemical family called organophosphates and works as a cholinesterase inhibitor, disrupting the nervous system of the lice. Malathion 0.5% lotion is FDA-approved for patients infected with head lice and their eggs (ova) of the scalp hair, and it is intended for patients 6 years of age and older. The CDC describes malathion as pediculicidal (it kills live lice) and partially ovicidal (it kills some, but not all, of the eggs), so combing the nits out after treatment is still part of the job.

Malathion lotion is applied to dry hair, left on for 8 to 12 hours, and then washed out with shampoo, followed by combing with a fine-toothed nit comb to remove dead lice and remaining eggs. A second application may be used 7 to 9 days later if live lice are still present, so it is important to re-check the scalp rather than assume one treatment finished the job. Because malathion is a prescription product, your doctor or nurse practitioner decides whether it is the right choice for you. It is often used as a second-line option when over-the-counter permethrin or pyrethrin products have failed because of lice resistance. This page is general information, not medical advice.

Malathion cost without insurance, and how coupons help

Malathion 0.5% lotion is available as a generic, but generic does not automatically mean cheap, and pharmacy cash prices for the same bottle are not standardized. Two pharmacies a few blocks apart can quote very different prices for the identical product, because each pharmacy sets its own cash price. That is why comparing is worth the two minutes it takes, especially if you are paying without insurance or if your plan does not cover lice treatments.

A malathion coupon from Rx.com is free to use and works like a cash-discount card: you show it at the pharmacy counter and pay the discounted cash price instead of the pharmacy's regular retail price. You do not need insurance, and there is no membership fee. If you do have insurance, you can still compare, because a coupon price is sometimes lower than a plan copay. Enter your ZIP code above to see today's malathion prices near you, then take the coupon to whichever pharmacy works best for you. There is no manufacturer savings card for generic malathion lotion.

Malathion vs. other head lice treatments

Several other medicines treat head lice, and they differ in age limits, prescription versus over-the-counter status, and how well they work against resistant lice:

  • Permethrin is the most familiar option. The 1% cream rinse is sold over the counter and is usually tried first, though lice resistance to it is common in many parts of the U.S. Malathion is frequently used when permethrin has not worked.
  • Spinosad topical suspension is a prescription lice treatment that generally does not require nit combing.
  • Topical ivermectin 0.5% lotion (Sklice) is a single-application option that is now sold over the counter. It is a different product from oral ivermectin tablets, which are not FDA-approved for head lice.

Compared with products that have little effect on eggs, malathion has the advantage of being partially ovicidal, meaning it kills some of the eggs in addition to the live lice. That is not the same as clearing every nit, so combing and the 7-to-9-day re-check still matter. Its main drawbacks are the long 8-to-12-hour application time, its strong odor, and the fact that the alcohol-based lotion is highly flammable. Which treatment is best depends on the patient's age, prior treatments, and local resistance patterns, so ask your provider or pharmacist rather than switching products on your own.

Safety, side effects, and the flammability warning

Malathion lotion has no boxed warning, but it does carry one warning that matters more than any other: the lotion is alcohol-based and highly flammable. Do not smoke while applying it, and keep the lotion and wet, treated hair away from open flames, hair dryers, curling irons, flat irons, and any other electric heat source until the hair is completely dry. Never use a hair dryer to speed up drying.

Malathion lotion is intended for patients 6 years of age and older; safety and effectiveness in children younger than 6 have not been established, so using it in a younger child is off-label and a decision only a prescriber can make. On top of that age limit, it is absolutely contraindicated in newborns and infants, whose scalps are more permeable and absorb more of the drug, and MedlinePlus tells patients it should not be used in children under 2 years old at all.

Malathion is for external use on the scalp only. Do not swallow it and avoid getting it in the eyes; if it does contact the eyes, flush them with water. Because malathion is an organophosphate cholinesterase inhibitor, swallowing it or a large overexposure can cause difficulty breathing, muscle twitching, heavy sweating or drooling, and a slow heartbeat, which is a medical emergency, so call for help right away. The usual side effects are local: scalp or skin irritation, stinging, and occasionally chemical burns or contact dermatitis. Use it only on the person it was prescribed for, and wash bedding, clothing, and hats in hot water. Talk to your doctor or pharmacist about your specific situation.

Sources & accuracy

This Malathion information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Malathion on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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