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Novolog 70/30 Pen — prescription drug image

Novolog 70/30

NovoLog Mix 70/30

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What is Novolog 70/30?

Novolog 70/30 is a pre-mixed insulin used to improve glycemic control in individuals with diabetes mellitus. It combines 70% insulin aspart protamine, an intermediate-acting insulin, and 30% insulin aspart, a rapid-acting insulin, to help manage blood sugar levels throughout the day. Administered subcutaneously, Novolog 70/30 is typically injected before meals to provide a balance of immediate and prolonged insulin action.

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What is Novolog 70/30 ?

Novolog 70/30 is a pre-mixed insulin used to improve glycemic control in individuals with diabetes mellitus. It combines 70% insulin aspart protamine, an intermediate-acting insulin, and 30% insulin aspart, a rapid-acting insulin, to help manage blood sugar levels throughout the day. Administered subcutaneously, Novolog 70/30 is typically injected before meals to provide a balance of immediate and prolonged insulin action.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat
  • Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
  • Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
  • This medicine may cause the following problems: Low blood sugar or low potassium levels in the bloodFluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
  • Never share insulin pens, needles, or cartridges with anyone. Sharing these can pass hepatitis viruses, HIV, and other illnesses from one person to another.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is NovoLog Mix 70/30 used for?

NovoLog Mix 70/30 is FDA-approved to improve blood sugar control in adults with diabetes mellitus. The label states that safety and effectiveness have not been established in pediatric patients. In adults it is used in both type 1 and type 2 diabetes, and it is most often given twice daily in type 2 diabetes. It is a fixed premix of 70% intermediate-acting insulin aspart protamine and 30% rapid-acting insulin aspart, so the background and mealtime portions cannot be adjusted separately. It is not recommended for treating diabetic ketoacidosis.

How long does NovoLog Mix 70/30 take to work, and when should I inject it?

The rapid-acting insulin aspart portion starts working in about 10 to 20 minutes. The label directs you to inject the dose under the skin within 15 minutes before you start your meal. In patients with type 2 diabetes only, the label allows the dose to also be given after the meal has been started; that after-meal option is not part of the labeled directions for type 1 diabetes. The intermediate-acting insulin aspart protamine portion works more slowly and lasts longer. It is typically injected twice a day with meals. Follow the exact timing and dose your prescriber gives you.

Who should not use NovoLog Mix 70/30?

The label contraindicates NovoLog Mix 70/30 during episodes of hypoglycemia (low blood sugar) and in people who are hypersensitive to NovoLog Mix 70/30 or one of its excipients. It is also not recommended for treating diabetic ketoacidosis, and safety and effectiveness have not been established in pediatric patients. Tell your prescriber about kidney or liver problems and about any other diabetes medicines you take, including thiazolidinediones such as pioglitazone or rosiglitazone, because your insulin needs may change.

What is the difference between NovoLog and NovoLog Mix 70/30?

NovoLog is rapid-acting insulin aspart alone, used to cover meals, and its dose can be adjusted meal by meal. NovoLog Mix 70/30 is a fixed premix: 70% intermediate-acting insulin aspart protamine plus 30% rapid-acting insulin aspart in one pen or vial. The premix covers both background and mealtime needs in a single injection, but because the ratio is fixed, you cannot change the basal and mealtime amounts independently. They are not interchangeable, so never switch between them without your prescriber's supervision.

Is there a generic version of NovoLog Mix 70/30?

No. Insulin aspart protamine and insulin aspart is a biologic, so there is no FDA-approved generic of NovoLog Mix 70/30, and no biosimilar has been approved for this 70/30 premix. (The insulin aspart biosimilar approved in 2025, Merilog, is rapid-acting insulin aspart, not the premix.) What is available is an unbranded version of the same product: Novo Nordisk sells the identical mix as Insulin Aspart Protamine and Insulin Aspart Injectable Suspension Mix 70/30, 100 units/mL, without the brand name, and a private-label version is sold at Walmart as ReliOn NovoLog Mix 70/30. Ask your pharmacist whether your prescription can be filled with the unbranded product, and compare prices on this page, since they vary by pharmacy.

How much does NovoLog Mix 70/30 cost, and how can I lower the price?

The cash price varies a lot by pharmacy, by pen versus vial, and by whether you get the brand or the unbranded version, so enter your ZIP above to see today's price at pharmacies near you. To lower it: use the free Rx.com coupon at the counter, ask about the unbranded insulin aspart protamine and insulin aspart 70/30, and check the manufacturer's official NovoCare savings program if you have commercial insurance (terms vary and government-insurance patients are generally excluded). Novo Nordisk also offers a patient assistance program for people who qualify.

How much does Novolog 70/30 3ML of (70-30) 100UNIT/ML cost without insurance?
The price of Novolog 70/30 3ML of (70-30) 100UNIT/ML without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Novolog 70/30 3ML of (70-30) 100UNIT/ML?
Common side effects of Novolog 70/30 3ML of (70-30) 100UNIT/ML may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat, Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness, Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Novolog 70/30 3ML of (70-30) 100UNIT/ML?
Generic versions may be available for Novolog 70/30 3ML of (70-30) 100UNIT/ML. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Novolog 70/30 3ML of (70-30) 100UNIT/ML on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Novolog 70/30 3ML of (70-30) 100UNIT/ML?
The cheapest pharmacy for Novolog 70/30 3ML of (70-30) 100UNIT/ML depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Novolog 70/30 3ML of (70-30) 100UNIT/ML near you.

Novolog 70/30 Coupons & Prices

NovoLog Mix 70/30

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Novolog 70/30 Pen — prescription drug image
Prescription
Novolog 70/30 3ml of (70-30) 100unit/ml (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Novolog 70/30 prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
3ml of (70-30) 100unit/ml · Pen 15 $162.99 $132.42

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

A NovoLog Mix 70/30 coupon from Rx.com is a free cash-price discount you can show at the pharmacy counter for premixed insulin aspart protamine and insulin aspart injectable suspension (70/30), the medicine sold as NovoLog Mix 70/30 and NovoLog Mix 70/30 FlexPen. Because insulin prices swing widely from one pharmacy to the next, enter your ZIP above to see today's price at pharmacies near you and compare the brand pen, the unbranded biologic version of the same medicine, and the ReliOn NovoLog Mix 70/30 sold at Walmart. The Rx.com coupon is a cash-pay option, so it does not require insurance and can be used by people who are uninsured, on Medicare, or turned down for a manufacturer savings card. This page is educational information, not medical advice.

What is NovoLog Mix 70/30 and how does it work?

NovoLog Mix 70/30 is a premixed insulin analog. Each milliliter contains 100 units of insulin in a fixed blend: 70% insulin aspart protamine suspension, which is intermediate-acting and works in the background, and 30% insulin aspart, which is rapid-acting and covers the rise in blood sugar from a meal. It is FDA-approved to improve glycemic control in adults with diabetes mellitus; the manufacturer's label states that safety and effectiveness have not been established in pediatric patients. In adults it is used in both type 1 and type 2 diabetes, most commonly twice a day in type 2 diabetes. It is injected under the skin.

Because the 70/30 ratio is fixed, the background (basal) portion and the mealtime (prandial) portion cannot be adjusted separately. The rapid-acting part begins working in about 10 to 20 minutes, so the label directs you to give the dose within 15 minutes before you start your meal. The label adds one exception: in patients with type 2 diabetes, the dose may also be given after the meal has been started. That after-meal option applies only to type 2 diabetes, so if you have type 1 diabetes, inject within 15 minutes before starting the meal unless your prescriber tells you otherwise. NovoLog Mix 70/30 is not recommended for treating diabetic ketoacidosis. Follow your prescriber's directions on dose and timing.

Manufacturer savings card vs. the Rx.com cash coupon

Novo Nordisk runs an official savings program for NovoLog Mix 70/30 through its NovoCare site, and it also offers a patient assistance program for people who qualify on income and other criteria. Manufacturer savings cards for brand insulin are generally limited to people with commercial (private) insurance, and they typically exclude anyone with Medicare, Medicaid, or other government coverage. Eligibility, expiration, and the amount of help vary and change over time, so check the manufacturer's own site for current terms rather than relying on a third-party summary.

The Rx.com coupon is different: it is a cash-price discount, not insurance and not a manufacturer card. That makes it useful in exactly the situations where the savings card falls short, such as when you are uninsured, when you have Medicare or Medicaid, or when the pharmacy tells you the card was declined. You can also compare it against your insurance copay and simply pay whichever way is cheaper that day. Enter your ZIP above to see today's price at pharmacies near you, and show the coupon to the pharmacist before they run the claim.

Other versions and alternatives

Insulin aspart protamine and insulin aspart is a biologic, so there is no FDA-approved generic of NovoLog Mix 70/30, and no biosimilar has been approved for this 70/30 premix. What does exist is an unbranded biologic: the same manufacturer sells the identical mix as Insulin Aspart Protamine and Insulin Aspart Injectable Suspension Mix 70/30, without the NovoLog brand name, and a private-label version is sold at Walmart as ReliOn NovoLog Mix 70/30. It is the same medicine at 100 units/mL, supplied as a 10 mL vial or a 3 mL FlexPen. Ask your pharmacist whether your prescription can be filled with the unbranded product, since cash prices vary by pharmacy, by pen versus vial, and by which version you buy.

Other insulins your prescriber may discuss include:

  • NovoLog and insulin aspart are the rapid-acting mealtime insulin alone, without the intermediate-acting component. They allow separate mealtime dosing, but they are not a premix.
  • Humulin 70/30 and Novolin 70/30 are premixes of human insulin (NPH plus regular), not analogs.
  • Humalog Mix75/25 is a different premixed insulin analog, made with insulin lispro protamine and insulin lispro instead of insulin aspart.

These products are not interchangeable dose for dose. Do not change your insulin product, strength, manufacturer, type, or injection regimen without your prescriber's supervision.

Safety information to know

NovoLog Mix 70/30 does not carry a boxed warning. The label lists two contraindications: do not use it during an episode of hypoglycemia, and do not use it if you are hypersensitive to NovoLog Mix 70/30 or any of its excipients. Its most common and potentially life-threatening side effect is hypoglycemia (low blood sugar). Risk goes up with dose changes, changes in meals or exercise, and other medicines that affect blood glucose. Insulin can also lower potassium, and severe hypokalemia can lead to trouble breathing, abnormal heart rhythms, and death, so your provider may monitor potassium if you are at risk. Severe allergic reactions, including anaphylaxis, are possible. Weight gain, injection-site reactions, and lipodystrophy (lumps or dents in the skin) can occur, so rotate your injection sites. Fluid retention and worsening heart failure can happen when insulin is used with thiazolidinediones such as pioglitazone or rosiglitazone. Insulin needs may drop if you have kidney or liver impairment.

Never share pens, cartridges, or needles with another person, even if you put on a new needle, because that can pass bloodborne infections. Do not dilute NovoLog Mix 70/30 or mix it with any other insulin. This summary is not medical advice and is not a complete list of risks. Talk with your doctor or pharmacist about your own situation, and read the manufacturer's prescribing information.

Sources & accuracy

This Novolog 70/30 information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Novolog 70/30 on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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