Novolog 70/30
NovoLog Mix 70/30
What is Novolog 70/30?
Novolog 70/30 is a pre-mixed insulin used to improve glycemic control in individuals with diabetes mellitus. It combines 70% insulin aspart protamine, an intermediate-acting insulin, and 30% insulin aspart, a rapid-acting insulin, to help manage blood sugar levels throughout the day. Administered subcutaneously, Novolog 70/30 is typically injected before meals to provide a balance of immediate and prolonged insulin action.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat
- Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
- This medicine may cause the following problems: Low blood sugar or low potassium levels in the bloodFluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
- Never share insulin pens, needles, or cartridges with anyone. Sharing these can pass hepatitis viruses, HIV, and other illnesses from one person to another.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Prescription savings · · · ·
What is Novolog 70/30 ?
Novolog 70/30 is a pre-mixed insulin used to improve glycemic control in individuals with diabetes mellitus. It combines 70% insulin aspart protamine, an intermediate-acting insulin, and 30% insulin aspart, a rapid-acting insulin, to help manage blood sugar levels throughout the day. Administered subcutaneously, Novolog 70/30 is typically injected before meals to provide a balance of immediate and prolonged insulin action.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat
- Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
- Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
- This medicine may cause the following problems: Low blood sugar or low potassium levels in the bloodFluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
- Never share insulin pens, needles, or cartridges with anyone. Sharing these can pass hepatitis viruses, HIV, and other illnesses from one person to another.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Novolog 70/30 Coupons & Prices
NovoLog Mix 70/30
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Novolog 70/30 prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 3ml of (70-30) 100unit/ml · Pen | 15 | $162.99 | $132.42 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
A NovoLog Mix 70/30 coupon from Rx.com is a free cash-price discount you can show at the pharmacy counter for premixed insulin aspart protamine and insulin aspart injectable suspension (70/30), the medicine sold as NovoLog Mix 70/30 and NovoLog Mix 70/30 FlexPen. Because insulin prices swing widely from one pharmacy to the next, enter your ZIP above to see today's price at pharmacies near you and compare the brand pen, the unbranded biologic version of the same medicine, and the ReliOn NovoLog Mix 70/30 sold at Walmart. The Rx.com coupon is a cash-pay option, so it does not require insurance and can be used by people who are uninsured, on Medicare, or turned down for a manufacturer savings card. This page is educational information, not medical advice.
What is NovoLog Mix 70/30 and how does it work?
NovoLog Mix 70/30 is a premixed insulin analog. Each milliliter contains 100 units of insulin in a fixed blend: 70% insulin aspart protamine suspension, which is intermediate-acting and works in the background, and 30% insulin aspart, which is rapid-acting and covers the rise in blood sugar from a meal. It is FDA-approved to improve glycemic control in adults with diabetes mellitus; the manufacturer's label states that safety and effectiveness have not been established in pediatric patients. In adults it is used in both type 1 and type 2 diabetes, most commonly twice a day in type 2 diabetes. It is injected under the skin.
Because the 70/30 ratio is fixed, the background (basal) portion and the mealtime (prandial) portion cannot be adjusted separately. The rapid-acting part begins working in about 10 to 20 minutes, so the label directs you to give the dose within 15 minutes before you start your meal. The label adds one exception: in patients with type 2 diabetes, the dose may also be given after the meal has been started. That after-meal option applies only to type 2 diabetes, so if you have type 1 diabetes, inject within 15 minutes before starting the meal unless your prescriber tells you otherwise. NovoLog Mix 70/30 is not recommended for treating diabetic ketoacidosis. Follow your prescriber's directions on dose and timing.
Manufacturer savings card vs. the Rx.com cash coupon
Novo Nordisk runs an official savings program for NovoLog Mix 70/30 through its NovoCare site, and it also offers a patient assistance program for people who qualify on income and other criteria. Manufacturer savings cards for brand insulin are generally limited to people with commercial (private) insurance, and they typically exclude anyone with Medicare, Medicaid, or other government coverage. Eligibility, expiration, and the amount of help vary and change over time, so check the manufacturer's own site for current terms rather than relying on a third-party summary.
The Rx.com coupon is different: it is a cash-price discount, not insurance and not a manufacturer card. That makes it useful in exactly the situations where the savings card falls short, such as when you are uninsured, when you have Medicare or Medicaid, or when the pharmacy tells you the card was declined. You can also compare it against your insurance copay and simply pay whichever way is cheaper that day. Enter your ZIP above to see today's price at pharmacies near you, and show the coupon to the pharmacist before they run the claim.
Other versions and alternatives
Insulin aspart protamine and insulin aspart is a biologic, so there is no FDA-approved generic of NovoLog Mix 70/30, and no biosimilar has been approved for this 70/30 premix. What does exist is an unbranded biologic: the same manufacturer sells the identical mix as Insulin Aspart Protamine and Insulin Aspart Injectable Suspension Mix 70/30, without the NovoLog brand name, and a private-label version is sold at Walmart as ReliOn NovoLog Mix 70/30. It is the same medicine at 100 units/mL, supplied as a 10 mL vial or a 3 mL FlexPen. Ask your pharmacist whether your prescription can be filled with the unbranded product, since cash prices vary by pharmacy, by pen versus vial, and by which version you buy.
Other insulins your prescriber may discuss include:
- NovoLog and insulin aspart are the rapid-acting mealtime insulin alone, without the intermediate-acting component. They allow separate mealtime dosing, but they are not a premix.
- Humulin 70/30 and Novolin 70/30 are premixes of human insulin (NPH plus regular), not analogs.
- Humalog Mix75/25 is a different premixed insulin analog, made with insulin lispro protamine and insulin lispro instead of insulin aspart.
These products are not interchangeable dose for dose. Do not change your insulin product, strength, manufacturer, type, or injection regimen without your prescriber's supervision.
Safety information to know
NovoLog Mix 70/30 does not carry a boxed warning. The label lists two contraindications: do not use it during an episode of hypoglycemia, and do not use it if you are hypersensitive to NovoLog Mix 70/30 or any of its excipients. Its most common and potentially life-threatening side effect is hypoglycemia (low blood sugar). Risk goes up with dose changes, changes in meals or exercise, and other medicines that affect blood glucose. Insulin can also lower potassium, and severe hypokalemia can lead to trouble breathing, abnormal heart rhythms, and death, so your provider may monitor potassium if you are at risk. Severe allergic reactions, including anaphylaxis, are possible. Weight gain, injection-site reactions, and lipodystrophy (lumps or dents in the skin) can occur, so rotate your injection sites. Fluid retention and worsening heart failure can happen when insulin is used with thiazolidinediones such as pioglitazone or rosiglitazone. Insulin needs may drop if you have kidney or liver impairment.
Never share pens, cartridges, or needles with another person, even if you put on a new needle, because that can pass bloodborne infections. Do not dilute NovoLog Mix 70/30 or mix it with any other insulin. This summary is not medical advice and is not a complete list of risks. Talk with your doctor or pharmacist about your own situation, and read the manufacturer's prescribing information.
This Novolog 70/30 information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Novolog 70/30 on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.