Olanzapine-Fluoxetine Hcl
OLANZapine-FLUoxetine HCl 3-25MG
What is Olanzapine-Fluoxetine Hcl?
Symbyax is a prescription medication used to treat bipolar disorder. Fluoxetine-olanzapine is the generic version of Symbyax. The average retail price of Symbyax is around $315 for a supply of 30, 3 mg capsules. Use our Rx.com savings offer to get great discounts on Symbyax at participating pharmacies near you.Side Effects
- Feeling very thirsty or hungry, change in how much or how often you urinate
- Lightheadedness, dizziness, fainting
- Red, swollen skin, trouble breathing, yellow skin or eyes
Warnings
- Tell your doctor if you are pregnant, or if you have liver disease, bleeding problems, diabetes, high cholesterol, glaucoma, prostate problems, problems with passing urine, breast cancer, mania, seizures, or severe constipation. Tell your doctor if you have had a heart rhythm problem (including QT prolongation), or if you have had a heart attack, heart failure, low blood pressure, or a stroke.
- Do not breastfeed while you are using this medicine.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Changes in behavior or moodDrug reaction with eosinophilia and systemic symptoms (DRESS)Neuroleptic malignant syndrome (a nerve and muscle problem)High blood sugar, cholesterol, or triglyceride levelsSerotonin syndrome (may be life-threatening when used with certain other medicines)Tardive dyskinesia (a muscle problem that may become permanent)Higher risk of bleedingHeart rhythm changesSexual problems
- This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Olanzapine-Fluoxetine Hcl ?
Symbyax is a prescription medication used to treat bipolar disorder. Fluoxetine-olanzapine is the generic version of Symbyax. The average retail price of Symbyax is around $315 for a supply of 30, 3 mg capsules. Use our Rx.com savings offer to get great discounts on Symbyax at participating pharmacies near you.- Feeling very thirsty or hungry, change in how much or how often you urinate
- Lightheadedness, dizziness, fainting
- Red, swollen skin, trouble breathing, yellow skin or eyes
- Seizures or tremors
- Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
- Fever, chills, cough, sore throat, and body aches
- Painful, prolonged erection of your penis
- Jerky muscle movement you cannot control (often in your face, tongue, or jaw)
- Unusual bleeding or bruising
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Confusion, weakness, and muscle stiffness or twitching
- Eye pain, trouble seeing
- Fast, pounding, or uneven heartbeat
- Unusual behavior, thoughts of hurting yourself or others, trouble sleeping, unusual dreams
- Tell your doctor if you are pregnant, or if you have liver disease, bleeding problems, diabetes, high cholesterol, glaucoma, prostate problems, problems with passing urine, breast cancer, mania, seizures, or severe constipation. Tell your doctor if you have had a heart rhythm problem (including QT prolongation), or if you have had a heart attack, heart failure, low blood pressure, or a stroke.
- Do not breastfeed while you are using this medicine.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Changes in behavior or moodDrug reaction with eosinophilia and systemic symptoms (DRESS)Neuroleptic malignant syndrome (a nerve and muscle problem)High blood sugar, cholesterol, or triglyceride levelsSerotonin syndrome (may be life-threatening when used with certain other medicines)Tardive dyskinesia (a muscle problem that may become permanent)Higher risk of bleedingHeart rhythm changesSexual problems
- This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- This medicine may make it more difficult for your body to cool down. Be careful to not become overheated during exercise or hot weather, because you could have heat stroke.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Trouble sleeping, unusual dreams
- Unusual behavior, thoughts of hurting yourself or others
- Unusual bleeding or bruising
Olanzapine-Fluoxetine Hcl Coupons & Prices
OLANZapine-FLUoxetine HCl 3-25MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Olanzapine-Fluoxetine Hcl prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 3-25mg · Capsule | 30 | $309.19 | $116.51 |
| 6-25mg · Capsule | 30 | $369.69 | $98.07 |
| 6-50mg · Capsule | 30 | $379.99 | $137.98 |
| 12-50mg · Capsule | 30 | $566.99 | $213.53 |
| 12-25mg · Capsule | 30 | $569.99 | $207.73 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Olanzapine and fluoxetine HCl capsules are the generic version of a combination antidepressant/antipsychotic medicine originally sold under the brand name Symbyax, which is no longer marketed in the US. If you're looking for an olanzapine-fluoxetine coupon, prices for this generic can vary a lot from pharmacy to pharmacy, so it's worth comparing before you fill. Enter your ZIP above to see today's price near you.
What Is Olanzapine and Fluoxetine HCl and How Does It Work?
This capsule combines olanzapine, an atypical antipsychotic, with fluoxetine, a selective serotonin reuptake inhibitor (SSRI). It's FDA-approved for the acute treatment of depressive episodes associated with Bipolar I Disorder, and separately for treatment-resistant depression, defined as major depressive disorder in adults who have not responded to two separate antidepressant trials of adequate dose and duration during the current episode. It comes as an oral capsule taken once daily, generally in the evening.
Comparing Prices on Olanzapine and Fluoxetine HCl
Because this is a generic medicine, the biggest lever for savings is simply comparing pharmacies rather than relying on a manufacturer coupon. Rx.com compares prices across more than 60,000 pharmacies, and cash prices for the same generic can differ significantly by location and pharmacy chain, so it's worth checking before you fill or refill. This medicine's brand-name predecessor, Symbyax, was discontinued years ago, so the generic combination capsule is the only version currently available.
Alternatives for Bipolar Depression or Treatment-Resistant Depression
- Olanzapine — the antipsychotic component on its own, also available generically, sometimes used together with a separate antidepressant.
- Fluoxetine — the SSRI component on its own, a widely used generic antidepressant.
- Quetiapine — another atypical antipsychotic with its own FDA approval for bipolar depression.
Which option makes sense depends on your diagnosis, prior treatment history, and how you tolerate side effects — this is a conversation for your prescriber, not a one-size-fits-all choice.
Safety Information
This medicine carries a boxed warning with two parts. First, like other antidepressants, it can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; it is not approved for use in young children. Second, because it contains an antipsychotic, elderly patients with dementia-related psychosis who are treated with this medicine are at increased risk of death; it is not approved for treating dementia-related psychosis. Combining it with an MAOI can be dangerous, and other risks can include metabolic changes (weight gain, blood sugar and cholesterol changes), sedation, and serotonin syndrome when combined with other serotonergic drugs. This isn't a complete list — talk with your prescriber or pharmacist about your full health history before starting this medicine.
This Olanzapine-Fluoxetine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Olanzapine-Fluoxetine Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
