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Paliperidone Er Tablet Extended Release 24 Hour — prescription drug image

Paliperidone Er

Paliperidone ER 6MG

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What is Paliperidone Er?

Paliperidone ER is an extended-release oral medication primarily used in the treatment of schizophrenia and schizoaffective disorder. It is an atypical antipsychotic that works by affecting certain neurotransmitters in the brain to help manage symptoms such as hallucinations, delusions, and mood swings. Paliperidone ER provides steady medication levels throughout the day, potentially improving compliance and reducing side effects compared to immediate-release formulations.

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What is Paliperidone Er ?

Paliperidone ER is an extended-release oral medication primarily used in the treatment of schizophrenia and schizoaffective disorder. It is an atypical antipsychotic that works by affecting certain neurotransmitters in the brain to help manage symptoms such as hallucinations, delusions, and mood swings. Paliperidone ER provides steady medication levels throughout the day, potentially improving compliance and reducing side effects compared to immediate-release formulations.
  • Unusual bleeding, bruising, or weakness
  • Trouble with speaking or swallowing.
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Swelling of the breasts or unusual milk production.
  • Unusual bleeding, bruising, or weakness.
  • Tremors or seizures
  • Sudden or severe headache, problems with vision, speech, or walking
  • Seizures or tremors.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chills, cough, sore throat, body aches
  • Difficulty swallowing (that can cause food or liquid to get into your lungs)
  • Fast, slow, pounding, or uneven heartbeat
  • Fever, confusion, sweating, muscle stiffness, loss of consciousness, troubled breathing
  • Lightheadedness, dizziness, fainting
  • Jerky muscle movements you cannot control (often in your face, tongue, or jaw)
  • Twitching or muscle movements you cannot control (often in your face, tongue, or jaw).
  • Painful, prolonged erection of the penis, which lasts for more than 4 hours
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, stomach or bowel problems (including blockage), Parkinson disease, dementia, trouble swallowing, or a history of breast cancer, seizures, or neuroleptic malignant syndrome. Tell your doctor if you have blood vessel or heart problems, heart failure, heart rhythm problems, low blood pressure, or a history of a heart attack or stroke.
  • This medicine may cause the following problems:Increased risk of strokeNeuroleptic malignant syndrome (a nerve disorder that could be life-threatening)Heart rhythm problem (including QT prolongation)Tardive dyskinesia (a muscle disorder that could become permanent)High blood sugar or high cholesterol levelsIncreased levels of prolactin hormoneIncreased risk of seizures
  • This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when suddenly getting up from a lying or sitting position, so stand up slowly.
  • This medicine lowers the number of white blood cells. This weakens your immune system, so you may get infections more easily. Wash your hands often. Avoid people who are sick.
  • This medicine may change how your body regulates temperature. Avoid activities that could cause you to become very cold, hot, or dehydrated.
  • Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor right away.
  • This medicine might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you or your child are too hot and cannot cool down.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood tests may be needed to check for any unwanted effects.
  • This medicine may increase your weight. Your doctor may need to check your or your child's weight regularly during treatment with this medicine.
  • Swelling of the breasts or unusual milk production.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Trouble with speaking or swallowing.
  • Unusual bleeding, bruising, or weakness.
  • Twitching or muscle movements you cannot control (often in your face, tongue, or jaw).
Is there a generic version of Invega?
Yes. Paliperidone extended-release tablets are the FDA-approved generic equivalent of Invega and are marketed by several manufacturers.
What is paliperidone ER used for?
It's approved to treat schizophrenia in adults and adolescents, and schizoaffective disorder in adults, as an oral extended-release tablet taken once daily.
Is paliperidone the same as risperidone?
They're related but not identical. Paliperidone is the main active metabolite the body produces from risperidone, and it's marketed as its own medication.
Does paliperidone ER have a boxed warning?
Yes. Like other antipsychotics, it carries a boxed warning that elderly patients with dementia-related psychosis face an increased risk of death and stroke; it is not approved for dementia-related behavior problems.
Can I use a coupon for paliperidone ER without insurance?
Yes, cash-pay coupons can be used with or without insurance. Compare pharmacy prices first, since they vary by location and by which generic manufacturer's tablets a pharmacy stocks.
How much does Paliperidone Er cost without insurance?
The price of Paliperidone Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 95% off retail prices with a free Rx.com coupon.
What are the common side effects of Paliperidone Er?
Common side effects of Paliperidone Er may include: Unusual bleeding, bruising, or weakness, Trouble with speaking or swallowing., Numbness or weakness in your arm or leg, or on one side of your body, Swelling of the breasts or unusual milk production., Unusual bleeding, bruising, or weakness.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Paliperidone Er?
Generic versions may be available for Paliperidone Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Paliperidone Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Paliperidone Er?
The cheapest pharmacy for Paliperidone Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Paliperidone Er near you.

Paliperidone Er Coupons & Prices

Paliperidone ER 6MG

Prescriptions & Refills
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Paliperidone Er Tablet Extended Release 24 Hour — prescription drug image
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Paliperidone extended-release tablets are the generic form of Invega, an atypical antipsychotic used for schizophrenia and schizoaffective disorder. Because several manufacturers make the extended-release tablet, cash prices can vary widely from one pharmacy to the next — enter your ZIP above to see today's price and find a paliperidone-er coupon near you.

What is paliperidone ER and how does it work?

Paliperidone is an atypical (second-generation) antipsychotic. It's the active metabolite of risperidone, and the extended-release (ER) tablet uses an osmotic delivery system (OROS) to release the drug slowly over the day, allowing once-daily dosing. The oral ER tablet is FDA-approved to treat schizophrenia and schizoaffective disorder in adults; it is also approved for schizophrenia in adolescents. This page covers the oral extended-release tablet only — it does not cover the long-acting injectable forms (such as Invega Sustenna or Invega Trinza), which have their own separate dosing, indications, and administration.

Comparing prices without insurance

Paliperidone ER is available as a generic from multiple manufacturers, alongside the brand Invega. Because generic manufacturer, pharmacy type, and location all affect cash price, the price you're quoted at one pharmacy can differ substantially from another for the exact same strength. Rx.com compares cash prices for paliperidone ER across more than 60,000 U.S. pharmacies so you can find a lower price nearby, whether or not you have insurance.

Paliperidone ER vs. Invega (brand) and related antipsychotics

  • Invega (brand paliperidone) is the same medicine as generic paliperidone ER; choosing the generic is typically the more affordable option when available at your pharmacy.
  • Risperidone is the parent drug that the body converts into paliperidone, and is prescribed for similar conditions.
  • Aripiprazole and quetiapine are other atypical antipsychotics sometimes used for schizophrenia or schizoaffective disorder; your prescriber chooses among these based on your specific symptoms and history.

Safety information

Paliperidone carries a boxed warning: elderly patients with dementia-related psychosis treated with antipsychotic drugs are at increased risk of death and of stroke or transient ischemic attack. Paliperidone ER is not approved for treating behavioral symptoms of dementia in older adults. Other risks with antipsychotics can include metabolic changes (weight gain, blood sugar and cholesterol changes), low blood pressure on standing, and rarely neuroleptic malignant syndrome. This is general information, not medical advice — talk with your prescriber about your full risk profile before starting or stopping this medication.

Sources & accuracy

This Paliperidone Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Paliperidone Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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