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Periomed

PerioMed 283.5GM of 0.63%

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What is Periomed?

PerioMed is an antimicrobial oral rinse containing 0.63% stannous fluoride, designed for the treatment of gingivitis and the reduction of dental plaque. Its formula promotes oral health by inhibiting bacterial growth and helping to prevent tooth decay, while also offering remineralization benefits to strengthen enamel.

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What is Periomed ?

PerioMed is an antimicrobial oral rinse containing 0.63% stannous fluoride, designed for the treatment of gingivitis and the reduction of dental plaque. Its formula promotes oral health by inhibiting bacterial growth and helping to prevent tooth decay, while also offering remineralization benefits to strengthen enamel.
  • Burning in your mouth, sore tongue.
  • Nausea, vomiting, or diarrhea.
  • Vomiting blood.
  • Make sure your doctor knows if you are pregnant or breast feeding. Tell your doctor if you are allergic to any foods, preservatives, or dyes.
  • Too much fluoride can cause white patches or stains on your teeth. If this happens, stop using the medicine and call your doctor.
  • If this medicine is being used by a child, an adult should watch the child and make sure they do not swallow the medicine. If they swallow too much of the medicine, it can cause fluoride toxicity. Ask your health caregiver if you have questions or concerns about this.
What is PerioMed used for?
PerioMed is a stannous fluoride oral rinse used to help prevent dental decay, control gingivitis and plaque bacteria, and reduce tooth sensitivity.
Do I need a prescription for PerioMed?
PerioMed is regulated as an over-the-counter product, but it's typically dispensed through a dental office as part of a recommended home-care routine rather than sold on general pharmacy shelves.
How is PerioMed different from a chlorhexidine rinse?
PerioMed uses stannous fluoride to strengthen enamel and reduce sensitivity, while chlorhexidine rinses like Peridex primarily reduce the bacteria associated with gingivitis. Your dentist may recommend one or the other, or both, depending on your needs.
How often should PerioMed be used?
Directions vary by dentist recommendation, but PerioMed is generally intended for daily use as a diluted rinse. Follow your dental provider's specific instructions.
How much does Periomed cost without insurance?
The price of Periomed without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 27% off retail prices with a free Rx.com coupon.
What are the common side effects of Periomed?
Common side effects of Periomed may include: Burning in your mouth, sore tongue., Nausea, vomiting, or diarrhea., Vomiting blood.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Periomed?
Generic versions may be available for Periomed. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Periomed on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Periomed?
The cheapest pharmacy for Periomed depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Periomed near you.

Periomed Coupons & Prices

PerioMed 283.5GM of 0.63%

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Periomed Bottle — prescription drug image
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Periomed 283.5gm of 0.63% (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Periomed prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
283.5gm of 0.63% · Bottle 283.5 $20.57 $14.96

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

PerioMed is a 0.63% stannous fluoride oral rinse dispensed by dental offices to help prevent cavities, control gingivitis, and reduce tooth sensitivity. It's regulated as an over-the-counter product but is typically provided through a dental practice rather than picked up at a retail pharmacy, so check a PerioMed coupon if you're comparing costs.

What Is PerioMed and How Does It Work?

PerioMed's active ingredient is stannous fluoride at 0.63% concentration, used as a diluted daily oral rinse. Stannous fluoride helps strengthen tooth enamel against decay, helps control plaque bacteria linked to gum inflammation, and can build protection against painful tooth sensitivity over time. It's typically prescribed or recommended by a dentist as part of a daily home-care routine alongside brushing and flossing.

Saving on PerioMed

Because PerioMed is usually dispensed directly through a dental office rather than stocked on pharmacy shelves, pricing can vary between dental supply channels and pharmacies that carry it. Enter your ZIP above to compare pricing on PerioMed before you buy, and ask your dental office whether they offer it directly.

PerioMed vs. Other Fluoride and Antigingivitis Rinses

PerioMed differs from chlorhexidine gluconate rinses such as Peridex, which target gingivitis primarily through antibacterial action rather than fluoride delivery. It also differs from everyday OTC fluoride mouth rinses in its higher stannous fluoride concentration, which is why it's meant to be used under a dentist's guidance rather than picked at random off a shelf.

Safety Information

  • PerioMed is a concentrate meant to be diluted with water as directed before rinsing; it should not be swallowed.
  • If sensitivity symptoms persist for more than four weeks of use, see a dentist, since ongoing sensitivity can sometimes point to a more serious issue.
  • Keep out of reach of children, and use in children under 6 only with a dentist's or doctor's guidance.
  • This is not medical advice — follow your dental provider's specific instructions for how and how often to use PerioMed.
Sources & accuracy

This Periomed information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Periomed on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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