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Polyethylene Glycol

Polyethylene Glycol 500GM of

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What is Polyethylene Glycol?

Polyethylene glycol (PEG) is a polyether compound widely used as an excipient in pharmaceuticals for its solubility and lubrication properties. It functions as an osmotic laxative, helping to relieve constipation by retaining water in the stool and increasing bowel movements. PEG is also employed in various formulations to improve the stability and delivery of active pharmaceutical ingredients.

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What is Polyethylene Glycol ?

Polyethylene glycol (PEG) is a polyether compound widely used as an excipient in pharmaceuticals for its solubility and lubrication properties. It functions as an osmotic laxative, helping to relieve constipation by retaining water in the stool and increasing bowel movements. PEG is also employed in various formulations to improve the stability and delivery of active pharmaceutical ingredients.
  • Bloating
  • Gas
  • Upset stomach
  • Dizziness
  • Cramping
  • Increased sweating
  • Do not use if you have kidney disease without consulting with a doctor.
  • Avoid prolonged use as it may lead to electrolyte imbalance or dependency.
  • Consult a healthcare provider before use if pregnant or breastfeeding.
  • Seek immediate medical attention if you experience severe or persistent abdominal pain, nausea, vomiting, or signs of an allergic reaction such as hives, swelling, or difficulty breathing.
  • Do not use in individuals with bowel obstruction or symptoms suggestive of a bowel obstruction.
What is polyethylene glycol 3350 (MiraLAX) used for?
It's an over-the-counter osmotic laxative used for occasional constipation and irregularity, and to help restore regularity when used for up to 7 days as the label directs. It's also commonly used off-label, under a doctor's direction, for longer-term management of chronic constipation and for pediatric functional constipation, though that's not what the OTC label covers on its own.
How long does it take for polyethylene glycol to work?
Response time varies from person to person. The OTC label is meant for use up to 7 days; if you don't have a bowel movement within that window, the label says to stop and check with a doctor, since ongoing constipation despite treatment can point to a different underlying issue that needs evaluation.
Is it safe to take MiraLAX every day for a long time?
The OTC label itself is intended for short-term use, up to 7 days, unless a doctor tells you otherwise. That said, longer-term use under a doctor's supervision, for weeks or months, is common in clinical practice for chronic constipation and is supported by clinical guidelines. If you think you need it regularly, it's worth talking to your doctor rather than using it long-term on your own.
What is the difference between MiraLAX and Dulcolax?
They're different types of laxatives. MiraLAX (polyethylene glycol 3350) is an osmotic laxative that works by pulling water into the stool to soften it. Dulcolax's active ingredient is bisacodyl, a stimulant laxative that works by triggering the intestinal muscles to contract. Both are available over the counter but work through different mechanisms, so one may suit you better than the other depending on your symptoms.
Can you take polyethylene glycol while pregnant or breastfeeding?
As with any over-the-counter medication, it's best to check with your doctor or pharmacist before using polyethylene glycol while pregnant or breastfeeding, so they can weigh in based on your specific situation. This page's sourced information does not include pregnancy-specific safety data, so don't rely on it alone for that decision.
How much does Polyethylene Glycol cost without insurance?
The price of Polyethylene Glycol without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 29% off retail prices with a free Rx.com coupon.
What are the common side effects of Polyethylene Glycol?
Common side effects of Polyethylene Glycol may include: Bloating, Gas, Upset stomach, Dizziness, Cramping. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Polyethylene Glycol?
Generic versions may be available for Polyethylene Glycol. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Polyethylene Glycol on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Polyethylene Glycol?
The cheapest pharmacy for Polyethylene Glycol depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Polyethylene Glycol near you.

Polyethylene Glycol Coupons & Prices

Polyethylene Glycol 500GM of

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Polyethylene Glycol 500gm of (0.2)
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Polyethylene glycol 3350, sold over the counter under brand names like MiraLAX and GlycoLax, is a generic-available osmotic laxative for occasional constipation, and it's still worth checking a polyethylene glycol coupon before you buy since prices for the same OTC product can vary by pharmacy; enter your ZIP above to see today's price near you.

What Is Polyethylene Glycol and How Does It Work?

Polyethylene glycol 3350 (often shortened to PEG 3350) is an osmotic laxative available over the counter under brand names including MiraLAX, GlycoLax, and ClearLax, as well as generic store-brand versions. It works by holding water in the stool, which softens it and increases the frequency of bowel movements. The OTC product is FDA-monograph approved for occasional constipation and irregularity, intended for use up to 7 days unless a doctor directs otherwise.

Higher-concentration versions of polyethylene glycol combined with electrolytes are also used in bowel-prep products such as GoLYTELY, NuLYTELY, TriLyte, MoviPrep, and Gavilyte, which are a different use case (cleansing the colon before a procedure) from the everyday OTC powder for occasional constipation.

How to Save on Polyethylene Glycol

Because polyethylene glycol 3350 is sold over the counter and a generic version is widely available, you don't need a prescription to buy it, but that doesn't mean every pharmacy charges the same price for the same box or bottle. A polyethylene glycol coupon can help you compare what different pharmacies near you are charging on a given day, and in some cases a prescribed version may be priced differently than the same product bought OTC, so it's worth comparing both routes.

Enter your ZIP code above to see today's price at pharmacies near you, and consider the generic or store-brand PEG 3350 alongside name brands like MiraLAX, since they use the same active ingredient.

Polyethylene Glycol vs. Other Laxatives

Polyethylene glycol isn't the only option for occasional constipation, and different laxative types work differently in the body. Lactulose and magnesium citrate are also osmotic laxatives that draw water into the bowel, similar to how PEG 3350 works. Senna and bisacodyl (the active ingredient in Dulcolax) are stimulant laxatives, which work by triggering the intestinal muscles to contract rather than by pulling in water. Docusate sodium is a stool softener that works more gently and is often used for prevention rather than for a fast bowel movement.

Which option makes sense depends on how quickly you need relief, how your body responds, and any other health conditions you have, so it's reasonable to ask a pharmacist or doctor which is the better fit if you're unsure.

Safety Information

The OTC label for polyethylene glycol 3350 does not carry a boxed warning. It does warn against using it for more than 7 days unless a doctor tells you to, and says to stop and check with a doctor if you don't have a bowel movement after use, if you notice rectal bleeding, or if new or worsening symptoms appear, since these can be signs of a more serious condition. It's not intended for children under 17 for OTC use without a doctor's guidance. Common side effects can include nausea, bloating, cramping, gas, and diarrhea. Electrolyte disturbances such as dehydration or low sodium have been reported rarely, more often with the higher-dose bowel-prep formulations or in people with kidney problems or who are also using other laxatives. People with kidney disease, a bowel obstruction, inflammatory bowel disease, or a known or suspected bowel perforation should use extra caution and talk to a doctor first. This is general information, not medical advice, always read the product label and check with your doctor or pharmacist about your specific situation.

Sources & accuracy

This Polyethylene Glycol information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Polyethylene Glycol on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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