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Prednisone

Prednisone

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What is Prednisone?

Prednisone is a prescription corticosteroid used to treat a wide range of inflammatory, allergic, and autoimmune conditions. It helps reduce inflammation and suppress the immune system, providing relief for conditions such as asthma, arthritis, lupus, severe allergies, and certain skin disorders.

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What is Prednisone ?

Prednisone is a prescription corticosteroid used to treat a wide range of inflammatory, allergic, and autoimmune conditions. It helps reduce inflammation and suppress the immune system, providing relief for conditions such as asthma, arthritis, lupus, severe allergies, and certain skin disorders.

  • Fever, chills, cough, sore throat, and body aches
  • Severe stomach pain, nausea, vomiting, or red or black stools
  • Trouble seeing, eye pain, headache
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Skin changes or growths
  • Muscle pain or weakness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark freckles, skin color changes, coldness, weakness, tiredness, nausea, vomiting, weight loss
  • Depression, unusual thoughts, feelings, or behaviors, trouble sleeping
  • Increased hunger or thirst, increase in how much or how often you urinate
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding or if you have kidney problems, heart failure, high blood pressure, a recent heart attack, diabetes, glaucoma, osteoporosis, or thyroid problems. Tell your doctor about any infection you have. Also tell your doctor if you have had mental or emotional problems (such as depression) or stomach or bowel problems (such as an ulcer or diverticulitis).
  • This medicine may cause the following problems:Mood or behavior changesHigher blood pressure, retaining water, changes in salt or potassium levels in your bodyCataracts or glaucoma (with long-term use)Weak bones or osteoporosis (with long-term use)Slow growth in children (with long-term use)Muscle problems (with high doses, especially if you have myasthenia gravis or similar nerve and muscle problems)
  • This medicine may raise your blood sugar level, especially in people with diabetes.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine could cause you to get infections more easily. Tell your doctor right away if you are exposed to chicken pox, measles, or other serious infection. Tell your doctor if you had a serious infection in the past, such as tuberculosis or herpes.
  • Tell your doctor about any extra stress or anxiety in your life. Your dose might need to be changed for a short time.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is prednisone used to treat?
Prednisone is a corticosteroid used to reduce inflammation and calm an overactive immune system. It's FDA-approved for a wide range of conditions, including rheumatoid arthritis, acute gout, lupus and other autoimmune diseases, severe allergic reactions, asthma and COPD flare-ups, certain skin conditions, some blood disorders, inflammatory bowel disease such as ulcerative colitis and Crohn's, and various hormone (endocrine) disorders. It's also commonly given as a short course to settle an acute flare.
What are the most common side effects of prednisone?
Common effects can include increased appetite, fluid retention, higher blood sugar, raised blood pressure, mood or sleep changes, and stomach upset. With longer use, prednisone can also contribute to bone thinning, cataracts or glaucoma, muscle weakness, and a higher risk of infection because it suppresses the immune system. Talk with your provider about which side effects to watch for at your dose.
Why can't you stop taking prednisone suddenly?
After you've taken prednisone for a prolonged period, your body reduces its own natural steroid production. Stopping abruptly can leave you short of that hormone, leading to adrenal insufficiency. To avoid this, your provider will usually taper the dose down gradually rather than stopping all at once. Always follow your prescriber's instructions and never quit on your own.
How long does prednisone stay in your system?
Prednisone is a relatively short-acting corticosteroid, and its effects and levels vary from person to person depending on dose and how long you've been taking it. Because individual timing differs, your best source for specifics is your doctor or pharmacist, who can advise based on your situation. This is general information, not medical advice.
Can you drink alcohol while taking prednisone?
Prednisone can irritate the stomach and affect blood sugar, and alcohol may add to those effects, so many people are advised to limit or avoid it while on prednisone. Whether any alcohol is okay depends on your dose, how long you're taking it, and your other health conditions. Ask your doctor or pharmacist for guidance specific to you.
How much does Prednisone cost without insurance?
The price of Prednisone without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Prednisone?
Common side effects of Prednisone may include: Fever, chills, cough, sore throat, and body aches, Severe stomach pain, nausea, vomiting, or red or black stools, Trouble seeing, eye pain, headache, Rapid weight gain, swelling in your hands, ankles, or feet, Skin changes or growths. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Prednisone?
Generic versions may be available for Prednisone. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Prednisone on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Prednisone?
The cheapest pharmacy for Prednisone depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Prednisone near you.

Prednisone Coupons & Prices

Prednisone

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Prednisone Tablet — prescription drug image
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Prednisone prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
1mg · Tablet 120 $35.99 $15.37
2.5mg · Tablet 30 $12.69 $7.13
5mg · Tablet 10 $11.99 $5.60
10mg · Tablet 10 $11.99 $4.57
20mg · Tablet 10 $11.99 $6.15
50mg · Tablet 10 $8.05

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a prednisone coupon? Prednisone is a widely used generic corticosteroid, and because it's generic it's already one of the more affordable prescriptions - but the cash price still varies a lot from one pharmacy to the next, sometimes for the very same tablet. Rx.com lets you compare prednisone prices across more than 60,000 pharmacies and pull a free discount coupon you can use at the counter, whether or not you have insurance. Enter your ZIP above to see today's price near you.

What is prednisone and how does it work?

Prednisone is a corticosteroid - specifically a glucocorticoid - that works as a systemic anti-inflammatory and immunosuppressant. In plain terms, it calms down inflammation and quiets an overactive immune response, which is why it's prescribed across so many different conditions. It's FDA-approved for a broad range of uses, including rheumatic conditions like rheumatoid arthritis and acute gout, autoimmune and collagen diseases such as lupus, severe allergic reactions, asthma and COPD flare-ups, certain skin conditions, some blood disorders, inflammatory bowel disease (ulcerative colitis and Crohn's), and hormone (endocrine) disorders.

Prednisone is available as a low-cost generic. It's also very commonly prescribed as a short "steroid taper" - a brief course at a decreasing dose - to settle an acute inflammatory flare. Your provider decides the dose and how long you take it based on your condition.

Prednisone cost and how to save without insurance

Because prednisone is generic, it's usually inexpensive compared with brand-name drugs - but "inexpensive" doesn't mean the price is the same everywhere. Cash prices for the exact same strength and quantity can differ widely between pharmacies, which is exactly why comparing before you fill is worth the few seconds it takes. If you're paying without insurance, or if a discount coupon beats your copay, a free Rx.com coupon can help.

Rx.com compares live prednisone prices across 60,000+ pharmacies so you can see where it's cheapest near you and grab a coupon at no cost. Enter your ZIP above to see today's price. There is no manufacturer savings card for generic prednisone - the savings come from comparing pharmacy cash prices and using a discount coupon.

Prednisone alternatives and related corticosteroids

Prednisone belongs to a family of corticosteroids that treat similar problems but differ in strength, how long they last, and how the body processes them. Your prescriber chooses among them based on your condition and needs. Related medications include prednisolone, methylprednisolone, dexamethasone, and hydrocortisone.

There is also a delayed-release form of prednisone sold under the brand name Rayos; older brands such as Deltasone, Sterapred, and Prednicot are largely discontinued, and standard immediate-release prednisone is what most people fill as a generic. You can compare prices on any of these on Rx.com. Only your provider can decide which corticosteroid is right for you - don't switch on your own.

Prednisone safety and important warnings

Prednisone has no boxed warning, but there are important things to know. Because it suppresses the immune system, it can increase your risk of infection and may mask the usual signs of one; live vaccines should generally be avoided while taking immunosuppressive doses. It's not used in people with a systemic (bodywide) fungal infection or a known allergy to it. Longer-term use carries risks such as higher blood sugar, raised blood pressure, fluid retention, bone thinning (osteoporosis), cataracts or glaucoma, stomach ulcers, muscle weakness, mood or sleep changes, and slowed growth in children.

One key point: after taking prednisone for a prolonged period, don't stop it abruptly. Your body needs a gradual taper to avoid adrenal problems - your provider will guide this. This is general information, not medical advice. Talk with your doctor or pharmacist about your dose, your other medications, and any side effects you notice.

Sources & accuracy

This Prednisone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Prednisone on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Prednisone — Articles & Guides

6 articles
Prednisone for Pain: How It Works, Side Effects, and Safe Tapering
Prednisone for Pain: How It Works, Side Effects, and Safe Tapering
Prednisone can quiet severe pain fast, but weight gain, mood swings, and insomnia are common. This 11-minute guide explains how the steroid works, what Reddit users wish they’d known, and how to taper safely.
What Is Hyperhidrosis? Causes of and Treatments for Excessive Sweating
What Is Hyperhidrosis? Causes of and Treatments for Excessive Sweating
Excessive sweating (hyperhidrosis) can soak shirts and erode confidence, but it is highly treatable. This guide explains why some people sweat far more than normal, who is most at risk, and how to stop it-with costs and pros/cons of every proven option.
Low Testosterone and Joint Pain: What’s the Connection?
Low Testosterone and Joint Pain: What’s the Connection?
Stiff knees, aching shoulders, and low energy sometimes share the same hidden cause: low testosterone. This guide explains the science behind hormone-related joint pain, shows you how to tell if your T levels are off, and offers evidence-based options for lasting relief.
High Calcitriol but Low Vitamin D: What It Means and What to Do
High Calcitriol but Low Vitamin D: What It Means and What to Do
Seeing a high 1,25-dihydroxyvitamin D (calcitriol) result next to a low 25-hydroxyvitamin D can be confusing—and sometimes dangerous. This guide explains what the pattern means, when it points to simple vitamin D deficiency versus something more serious, and the exact lab work and treatments doctors use to fix it.
GHK-Cu Peptide Injection: Before and After Results Timeline
GHK-Cu Peptide Injection: Before and After Results Timeline
Thinking about GHK-Cu injections for younger-looking skin or thicker hair? This evidence-based guide explains what the copper peptide is, how it works, realistic before-and-after timelines, side-effects and when to call your doctor.
GHK-Cu Peptide: How the Copper Tripeptide Rebuilds Skin and Hair
GHK-Cu Peptide: How the Copper Tripeptide Rebuilds Skin and Hair
GHK-Cu is a copper-bound tripeptide that signals your skin to make fresh collagen, calm inflammation, and even coax dormant hair follicles back into action. This guide reviews the human and animal research, typical cosmetic concentrations, side-effect profile, and how U.S. compounding rules treat GHK-Cu.
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