Sorafenib Tosylate Coupons & Prices

A sorafenib tosylate coupon from Rx.com can lower what you pay out of pocket for the generic version of Nexavar, an oral multikinase inhibitor used to treat certain kidney, liver, and thyroid cancers. Sorafenib is usually filled through a specialty pharmacy rather than a regular retail counter, and cash prices can differ a great deal from one pharmacy to the next, so it is worth comparing before you fill. Enter your ZIP code above to see today's price at pharmacies near you, then show the free coupon at the register or have your pharmacy apply it.

What is sorafenib tosylate and how does it work?

Sorafenib (sold under the brand name Nexavar) is an oral multikinase inhibitor, a type of antineoplastic tyrosine kinase inhibitor. It blocks several signaling proteins that cancer cells and blood vessels use to grow, including c-CRAF, BRAF and mutant BRAF, KIT, FLT-3, RET and RET/PTC, VEGFR-1, VEGFR-2, VEGFR-3, and PDGFR-beta. By interfering with these pathways, sorafenib can slow tumor growth and limit the new blood vessels that feed a tumor.

The FDA has approved sorafenib tablets for three uses: advanced renal cell carcinoma (kidney cancer); unresectable hepatocellular carcinoma (liver cancer); and locally recurrent or metastatic, progressive, differentiated thyroid carcinoma that no longer responds to radioactive iodine treatment. Sorafenib is taken on an empty stomach, either 1 hour before or 2 hours after a meal. Your oncologist decides the dose and schedule; this page is general information, not medical advice.

Sorafenib cost without insurance and how the coupon helps

A generic version of sorafenib tosylate is FDA-approved and available in the United States, and generics are typically dispensed in place of the brand unless your prescriber specifies otherwise. That said, do not assume the cash price is the same everywhere. Pharmacy cash prices for the same drug, same strength, and same quantity can vary widely, which is exactly why comparing is worth your time. Rx.com compares prices across more than 60,000 pharmacies so you can see what each one charges near you before you commit to filling.

Sorafenib is generally handled through specialty pharmacies, so it helps to confirm ahead of time that the pharmacy you choose can order and dispense it and will accept a discount coupon. Enter your ZIP code above to see today's price and the pharmacies in your area. There is no manufacturer savings card for the generic; if you are taking brand-name Nexavar, you can look for any current support programs on the manufacturer's official website, and note that program terms vary and change over time. Our coupon is a cash-price discount and is not insurance, but you can compare it against your plan's copay and use whichever is lower.

Sorafenib compared with other kinase inhibitors

Sorafenib is one of several oral kinase inhibitors used in kidney, liver, and thyroid cancers. Which one is right for a given person depends on the specific cancer, prior treatments, and how well the drug is tolerated, and that decision belongs to your oncologist. Only your care team should change or substitute a cancer therapy.

• Nexavar is the brand name for sorafenib tosylate, the same medicine as this generic.
• Lenvatinib is another oral kinase inhibitor used in some of the same cancer settings.
• Sunitinib is an oral kinase inhibitor commonly discussed in advanced kidney cancer.
• Regorafenib is a related oral multikinase inhibitor.
• Pazopanib is another oral kinase inhibitor option.

Because these medicines are priced very differently and are filled through specialty pharmacies, comparing prices for whichever one you are prescribed is worthwhile.

Safety information you should know

Sorafenib does not carry a boxed warning. Its FDA label does describe several important risks: cardiac ischemia and heart attack; bleeding that requires medical treatment; high blood pressure, with blood pressure monitoring recommended weekly during the first 6 weeks of treatment; skin reactions including hand-foot skin reaction and rash, and rarely severe reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis; gastrointestinal perforation; QT interval prolongation; drug-induced hepatitis; and impaired wound healing, so treatment is withheld before major surgery. Sorafenib can harm an unborn baby, and effective contraception is required. Taking sorafenib with warfarin can raise INR and bleeding risk.

Sorafenib is contraindicated in people with known severe hypersensitivity to sorafenib and in combination with carboplatin and paclitaxel in squamous cell lung cancer. Studies found increased mortality when sorafenib was used with carboplatin/paclitaxel or with gemcitabine/cisplatin in squamous cell non-small cell lung cancer. Tell your oncologist about every medicine and supplement you take, and report chest pain, unusual bleeding, severe rash, or severe stomach pain right away. This is a summary, not medical advice; read the full label and talk with your provider.