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Xelstrym

Xelstrym 30 Patch

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What is Xelstrym?

Xelstrym™ is an FDA-approved dexmethylphenidate transdermal system specifically designed to treat Attention Deficit Hyperactivity Disorder (ADHD) in patients aged six years and older. This innovative patch technology provides a sustained release of medication for up to 12 hours, offering an alternative to oral ADHD medications and allowing for customizable dosage control. Xelstrym™ is applied directly to the skin and facilitates consistent delivery of medication, potentially improving adherence and patient outcomes.

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What is Xelstrym ?

Xelstrym™ is an FDA-approved dexmethylphenidate transdermal system specifically designed to treat Attention Deficit Hyperactivity Disorder (ADHD) in patients aged six years and older. This innovative patch technology provides a sustained release of medication for up to 12 hours, offering an alternative to oral ADHD medications and allowing for customizable dosage control. Xelstrym™ is applied directly to the skin and facilitates consistent delivery of medication, potentially improving adherence and patient outcomes.
  • Anxiety, fever, muscle spasms, seizures, twitching
  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
  • Sudden or severe headache, problems with vision, speech, or walking
  • Sores, coldness, numbness, color changes or unexplained wounds on your fingers or toes
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Constipation, diarrhea, nausea, vomiting, stomach pain
  • Chest pain that may spread, fast, pounding, or uneven heartbeat, dizziness
  • Sudden or severe headache, problems with vision, speech, or walking
  • Slow growth or weight loss in children
  • Blurred vision, lightheadedness or fainting, muscle cramps, seeing, hearing, or feeling things that are not there, sweating, trouble breathing
  • Severe skin redness, swelling, itching, or blistering where the patch is worn
  • Extreme energy or restlessness, confusion, agitation, unusual moods or behaviors
  • Tell your doctor if you are pregnant, or if you have kidney disease, heart or blood vessel disease, heart rhythm problems, high blood pressure, heart failure, Tourette syndrome, or a history of heart attack, stroke. Tell your doctor if you or anyone in your family has a history of depression, bipolar disorder, mental health problems, or drug or alcohol abuse.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may cause the following problems: Sudden death in people who have serious heart problems (including a heart defect)Serious heart or blood vessel problems, including heart attack and stroke (especially in people who already have heart problems)High blood pressureUnusual changes in behavior or moodsSlow growth in childrenPeripheral vasculopathy (a blood circulation problem), including Raynaud phenomenonSerotonin syndrome (when used with certain medicines)Skin site reactionsOnset or worsening of motor or verbal tics (including Tourette syndrome)
  • Do not breastfeed during treatment with this medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep the patch away from heat, including hair dryer, heating pads, electric blankets, or water beds.
What is Xelstrym used for?
Xelstrym is FDA-approved to treat Attention-Deficit/Hyperactivity Disorder (ADHD) in adults and in children 6 years of age and older. It is a dextroamphetamine skin patch, the first and only FDA-approved amphetamine transdermal system. Unlike oral dextroamphetamine products, the patch is not approved for narcolepsy, and it is not approved for weight loss or obesity.
How long do you leave a Xelstrym patch on?
The label directs applying the patch about 2 hours before an effect is needed and removing it within 9 hours. The strengths are labeled per 9 hours (4.5 mg/9 hr, 9 mg/9 hr, 13.5 mg/9 hr, and 18 mg/9 hr). Apply to clean, dry skin on the upper arm, upper back, hip, chest, or flank, and rotate the site. Keep the patch away from outside heat sources like heating pads, electric blankets, and hot tubs, because heat can increase how much drug is absorbed. Follow your prescriber's directions.
Is Xelstrym the same as Adderall?
No. Both are amphetamine-family stimulants for ADHD, but they are different products. Xelstrym is a dextroamphetamine patch worn on the skin. Adderall is an oral tablet containing mixed amphetamine salts. They are not interchangeable, and doses do not translate from one to the other. Only your prescriber can decide which is right for you.
Is there a generic version of Xelstrym?
No. There is no generic Xelstrym patch. It is brand-only, and it is the only amphetamine patch available, so a pharmacist cannot substitute a cheaper equivalent. To lower the cost you can compare cash prices with an Rx.com coupon, look into the manufacturer's official savings program at xelstrym.com (generally for people with commercial insurance; terms vary), or ask your prescriber about other ADHD medicines that do have generics.
What are the most common side effects of Xelstrym?
Because Xelstrym is a patch, application site reactions are a known issue, and some people develop contact sensitization, which may mean stopping all amphetamine products. The label also warns about increases in blood pressure and heart rate, psychiatric reactions, slowed growth in children, peripheral vasculopathy including Raynaud's phenomenon, serotonin syndrome with serotonergic drugs, and tics. This is not a complete list. Report any side effect to your doctor or pharmacist, and get help right away for chest pain, fainting, or trouble breathing.
How much does Xelstrym cost without insurance?
The price of Xelstrym without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Xelstrym?
Common side effects of Xelstrym may include: Anxiety, fever, muscle spasms, seizures, twitching, Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, Sudden or severe headache, problems with vision, speech, or walking, Sores, coldness, numbness, color changes or unexplained wounds on your fingers or toes, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Xelstrym?
Generic versions may be available for Xelstrym. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Xelstrym on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Xelstrym?
The cheapest pharmacy for Xelstrym depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Xelstrym near you.

Xelstrym Coupons & Prices

Xelstrym 30 Patch

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A Xelstrym coupon can lower what you pay at the pharmacy counter for Xelstrym (dextroamphetamine transdermal system), the first and only FDA-approved amphetamine patch for ADHD. Xelstrym is a brand-only product with no generic version, so the cash price can be high. Enter your ZIP above to see today's price at pharmacies near you and print or text yourself a free Rx.com coupon. There is no membership and no sign-up: you show the coupon with your prescription at the pharmacy.

What is Xelstrym and how does the patch work?

Xelstrym is a skin patch (transdermal system) that delivers dextroamphetamine, a central nervous system stimulant in the amphetamine family. It is FDA-approved to treat Attention-Deficit/Hyperactivity Disorder (ADHD) in adults and in children 6 years of age and older. It was approved in March 2022 and is made by Noven Therapeutics, LLC. It is a Schedule C-II controlled substance.

Instead of swallowing a pill, the patient applies the patch to clean, dry skin on the upper arm, upper back, hip, chest, or flank, rotating the site each day. The label directs applying it about 2 hours before an effect is needed and removing it within 9 hours. Xelstrym comes in four strengths: 4.5 mg/9 hr, 9 mg/9 hr, 13.5 mg/9 hr, and 18 mg/9 hr. Unlike oral dextroamphetamine products, the patch is not approved for narcolepsy and is not approved for weight or obesity management. It is not for children under 6.

Manufacturer savings card vs. the Rx.com cash coupon

Noven runs an official co-pay savings program for Xelstrym, described on the manufacturer's own website (xelstrym.com). Like most brand co-pay cards, it is generally limited to people with commercial (private) insurance, and the terms, eligibility, and any limits vary and change over time. People with Medicare, Medicaid, TRICARE, or other government coverage are typically excluded, and so are people with no insurance at all. Check the manufacturer's site or ask your prescriber's office for the current terms before you count on it.

That is where a cash coupon fits. The Rx.com coupon is a cash-price discount, not insurance, so it can be used if you are uninsured, if you are on Medicare or another government plan that blocks the manufacturer card, or if the card is declined or your plan will not cover the patch. You cannot combine a cash coupon with insurance on the same fill, so it is worth comparing both. Prices vary a lot by pharmacy and ZIP code, so enter your ZIP above to see today's price near you. It is also worth asking the manufacturer whether any patient-assistance option exists if cost is a barrier.

Is there a generic, and what are the alternatives?

There is no generic version of the Xelstrym patch. It is the only amphetamine patch on the market, so no substitutable generic of this exact formulation exists and a pharmacist cannot swap it for a cheaper equal. That makes a cash coupon or the manufacturer program the main levers on price for this specific product.

If cost is the problem, the conversation to have with your prescriber is about other ADHD medicines, several of which do have generics. Only a prescriber can decide whether a different drug or form is appropriate, and doses are not interchangeable between forms. Options they may discuss include:

Safety information you should know

Xelstrym carries a BOXED WARNING: amphetamines have a high potential for abuse and misuse, which can lead to substance use disorder including addiction, and overdose can be fatal. Your prescriber should assess your risk of abuse, misuse, and addiction before prescribing and keep monitoring during treatment. Xelstrym should not be used by anyone with a hypersensitivity to amphetamine products, or by anyone taking an MAO inhibitor now or within the past 14 days.

Other warnings on the label include sudden death and serious heart events in people with structural heart abnormalities or other serious heart problems; increases in blood pressure and heart rate; psychiatric reactions such as psychosis, mania, or new or worsening behavior problems and bipolar symptoms; slowed growth in children; peripheral vasculopathy including Raynaud's phenomenon; serotonin syndrome when combined with serotonergic drugs; and tics or worsening of Tourette's. Because it is a patch, there are also patch-specific risks: contact sensitization (which may mean stopping all amphetamine products), application site reactions, and increased drug absorption if the patch is exposed to outside heat such as heating pads, electric blankets, or hot tubs. Rotate application sites. This page is information, not medical advice. Talk with your doctor or pharmacist about your own health history and any other medicines you take.

Sources & accuracy

This Xelstrym information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Xelstrym on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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