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Healthy aging

NAD+ injections, prescribed online

NAD+ is a coenzyme your cells use to make energy and repair DNA, and levels fall with age. Get at-home NAD+ injections through a confidential online visit with a U.S.-licensed provider.

  • 100% online, confidential visit
  • Reviewed by U.S.-licensed providers
  • Compounded by licensed U.S. pharmacies, shipped free
  • No insurance or membership needed

Your treatment

NAD+ Injection

100 mg/mL (10 mL vial). Self-injected at home; your provider sets the dose.

Get Started
  • Prescription required, provider reviewed
  • Save on 3, 6 and 12 month plans
  • Plans don't auto-renew
  • Free shipping if prescribed

Prefer no needles? See NAD+ nasal spray

Upfront pricing Free delivery No membership fees U.S.-licensed providers No insurance needed

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in your body. Your mitochondria need it to turn food into ATP, the energy cells run on, and it fuels enzymes such as sirtuins and PARPs that help repair DNA and respond to stress.

NAD+ levels decline as we age, and researchers are studying whether restoring them supports energy, metabolism and healthy aging. Injections deliver NAD+ directly rather than relying on the body to build it from oral precursors like NMN or NR.

The science is promising but early. Most human studies are small and short, and NAD+ injections are not approved to treat any condition. A provider reviews your health history and goals to decide whether it makes sense for you.

People use NAD+ for goals like:

  • Day-to-day energy and stamina
  • Mental clarity and focus
  • Recovery from exercise and sleep quality
  • Supporting a broader healthy-aging routine
How it works

What NAD+ does in your cells

NAD+ takes part in hundreds of chemical reactions. These are the three that get the most research attention.

01

Cellular energy

Mitochondria

NAD+ carries electrons in the mitochondria so cells can produce ATP. Lower NAD+ is linked in research to less efficient energy production.

02

DNA repair

PARP enzymes

PARP enzymes use NAD+ to repair everyday DNA damage. When NAD+ runs low, this repair work competes with other uses for it.

03

Stress response

Sirtuins

Sirtuins (such as SIRT1 and SIRT3) depend on NAD+ and help regulate metabolism, inflammation and how cells respond to stress.

How to use it

Use it exactly as prescribed

NAD+ is injected at home with a small needle, usually just under the skin of the belly or thigh. Your provider sets the dose and how often you inject, often several days a week, and your prescription label has the instructions. Many people start at a lower dose and build up, which helps limit flushing.

NAD+ is not a substitute for the basics. Sleep, exercise and diet still do most of the work in any healthy-aging plan.

Good to know

  • Inject slowly; flushing or warmth is common and usually passes
  • Rotate injection sites to reduce soreness
  • Store the vial as directed on the label
  • Never use more than prescribed

Get started in 3 steps

100% online, with free shipping if a prescription is approved.

1

Answer a health questionnaire

A short, confidential online intake about your health history and goals.

2

A provider reviews it

A U.S.-licensed provider decides whether NAD+ is appropriate for you, and at what dose.

3

Get your medication

A licensed U.S. pharmacy compounds your prescription and ships it to your door.

NAD+ injection FAQs

What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell. It helps turn food into usable energy in the mitochondria and is used by enzymes involved in DNA repair, including sirtuins and PARPs. NAD+ levels tend to fall with age, which is why it is studied in healthy-aging research.
What are NAD+ injections used for?
People most often use NAD+ injections for energy, mental clarity and healthy-aging goals. Research on NAD+ is promising but still early: most human studies are small, and injectable NAD+ has not been proven to treat or prevent any disease. A provider will talk through what you can realistically expect.
Is NAD+ injectable FDA-approved?
No. NAD+ injectable is a compounded medication prepared by a licensed U.S. pharmacy for an individual prescription. Compounded medications are not FDA-approved, which means the FDA has not reviewed them for safety, effectiveness or quality.
How is it taken?
NAD+ is injected at home with a small needle, usually under the skin (subcutaneous). Your provider sets the dose and schedule, which is often several times a week, and your prescription comes with instructions. Starting low helps limit flushing and other side effects.
What side effects can NAD+ cause?
The most common are soreness, redness or a stinging feeling at the injection site, a warm flushing sensation, headache and lightheadedness. Less often people notice nausea, stomach upset, tiredness, trouble sleeping or feeling jittery in the first few doses. These are usually mild and often ease as your body adjusts or with a lower dose.
How soon will I notice anything?
It varies. Some people say they feel more energetic or clear-headed within the first few days, and others notice little change. Because the research is limited, there is no guaranteed timeline or result. Tell your provider how you feel so they can adjust your plan.
NAD+ injections vs. NMN or NR supplements?
NMN and NR are over-the-counter precursors your body converts into NAD+. Injections deliver NAD+ itself and skip the digestive system. Supplements are cheaper and need no prescription; injections are prescription-only. There is no good head-to-head evidence that one produces better results, so it is reasonable to ask your provider whether a supplement is enough for your goals.
Who should not use NAD+ injections?
NAD+ is not recommended during pregnancy or breastfeeding because it has not been studied there. Tell your provider if you have cancer or a history of cancer, heart disease, liver or kidney disease, or take other medications, so they can decide whether it is appropriate for you.
Do I need a prescription?
Yes. You complete an online health questionnaire, a U.S.-licensed provider reviews it, and if treatment is appropriate a licensed U.S. pharmacy fills your prescription and ships it to you.
Does insurance cover it?
No insurance is needed. NAD+ is cash pay with upfront pricing: from $99 a month on a prepaid 3, 6 or 12 month plan, or $179 for a single month. Plans do not auto-renew. Most insurance plans do not cover compounded NAD+. You may be able to use an HSA or FSA card; check with your plan administrator.

See if NAD+ is right for you

Complete a short online visit and a licensed provider will decide whether NAD+ injections fit your health history and goals.

Get Started

Important safety information

NAD+ injectable is a compounded medication. Compounded medications are not FDA-approved, and the FDA has not reviewed them for safety, effectiveness or quality. NAD+ is not approved to diagnose, treat, cure or prevent any disease, and statements on this page have not been evaluated by the FDA.

Common side effects include injection-site soreness or redness, flushing, headache and lightheadedness; nausea, fatigue, sleep changes or jitteriness are less common. Do not use NAD+ if you are pregnant or breastfeeding. Tell the provider about all your health conditions, including any history of cancer, and every medication and supplement you take. Get medical care right away for signs of an allergic reaction such as hives, swelling of the face or throat, or trouble breathing.

Articles & Guides

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Prescription required: Medications are only prescribed when clinically appropriate after a provider evaluation. This page is for information and is not a substitute for professional medical advice.

Medical services: All medical services, including clinical evaluations, treatment planning and prescribing decisions, are provided exclusively by licensed independent medical providers. Rx.com provides the technology platform and administrative coordination services, does not employ healthcare providers, and does not practice medicine.

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