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Prescription Peptide Therapy

PT-141: The Peptide That Works on Desire, Not Blood Flow

PT-141 (bremelanotide) activates the brain's own arousal pathways — a completely different mechanism from ED pills. Prescribed online by U.S.-licensed clinicians and compounded at a licensed U.S. pharmacy, shipped discreetly to your door.

  • Targets desire and arousal at the source
  • As-needed dosing — no daily pill
  • Prescribed online, no in-person visit
  • Discreet, unbranded packaging

Compounded PT-141

PT-141 by Telos Rx

$40 first month

On a 12-month plan ($160/mo after). Cancel anytime, no penalties.

  • Online clinician consultation included
  • Personalized dosing protocol
  • Free 48-hour shipping
  • 24/7 unlimited doctor messaging
  • FSA/HSA eligible — no insurance needed
Start Your Online Visit 5-minute intake. Clinician review, typically within 4 hours.
U.S.-licensed clinicians Licensed U.S. compounding pharmacy Review typically within 4 hours Plain, unmarked packaging

What is PT-141?

PT-141 is the peptide better known to the FDA as bremelanotide — approved in 2019 under the brand name Vyleesi for low sexual desire (hypoactive sexual desire disorder, or HSDD) in premenopausal women.

It is fundamentally different from every ED pill on the market. Sildenafil, tadalafil and the other PDE5 inhibitors work on blood flow. PT-141 works in the brain, activating the melanocortin receptors involved in sexual desire and arousal. It addresses the wanting, not just the mechanics.

Because it is prescription-only, every order starts with an online health intake reviewed by a U.S.-licensed clinician. If approved, a licensed U.S. compounding pharmacy fills your personalized prescription and ships it free in plain packaging — typically within 48 hours.

How PT-141 works

A melanocortin receptor agonist that activates central arousal pathways — a different mechanism from blood-flow drugs.

1

Melanocortin activation

PT-141 activates melanocortin receptors (primarily MC4R) in the central nervous system — the pathways involved in sexual arousal and desire.

2

Central, not vascular

Unlike PDE5 inhibitors that work on blood flow, PT-141 acts in the brain, addressing the desire and arousal signal itself.

3

As-needed effect

Taken ahead of intimacy as a small subcutaneous dose, it produces a time-limited effect — it fits around your life rather than requiring a daily regimen.

Check Your Eligibility Free intake — a clinician confirms whether PT-141 is right for you.

Why people choose PT-141

  • Works on desire — the part ED pills never touch
  • Studied for HSDD with measurable improvements in desire
  • As-needed protocol, no daily medication to maintain
  • Acts on arousal signaling, so it can complement an existing hormone protocol
  • Clinician-guided dosing, adjusted to your response
  • One flat subscription — consultation, medication and shipping included

Transparent pricing

Longer plans unlock the lowest monthly price. Every plan includes the clinician consultation, unlimited care-team messaging and free 2-day shipping. Cancel anytime in one click.

Best value

12 months

$40 first month

$160/mo after · billed every 48 weeks

Most popular

6 months

$99 first month

$180/mo after · billed every 24 weeks

·

3 months

$129 first month

$235/mo after · billed every 12 weeks

·

1 month

$249 first month

$249/mo · billed every 4 weeks

See If You Qualify Free 48-hour shipping if approved · FSA/HSA eligible · Cancel anytime

How it works

1

Complete your intake

Five minutes online covering your health history and goals. No appointment, no waiting room.

2

Clinician review

A U.S.-licensed clinician reviews your intake — typically within about 4 hours — and prescribes if PT-141 is right for you.

3

Personalized protocol

Your dose and timing are tailored to you, not a flat template, and adjusted as your care team learns how you respond.

4

Discreet delivery

Shipped free from a licensed U.S. compounding pharmacy in plain packaging, typically within 48 hours.

Start Your Online Visit

Important safety information

Bremelanotide temporarily raises blood pressure after each dose. It should not be used by people with uncontrolled high blood pressure or known cardiovascular disease. The most common side effects are nausea, flushing, headache and injection-site reactions.

Repeated use can cause focal darkening of the skin or gums (hyperpigmentation) that may not fully resolve; the risk increases with more than 8 doses per month. PT-141 can slow stomach emptying and affect the absorption of some oral medications — do not combine it with oral naltrexone. Share your complete health history and medication list honestly during the online intake, and seek medical care for severe or persistent side effects.

PT-141 FAQs

What is PT-141?
PT-141 is the research name for bremelanotide, a melanocortin peptide that activates arousal pathways in the brain rather than working on blood flow. The FDA approved bremelanotide in 2019 under the brand name Vyleesi for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Through our partner Telos Rx, a U.S.-licensed clinician can prescribe compounded PT-141, filled by a licensed U.S. compounding pharmacy.
How is PT-141 different from Viagra or other ED pills?
ED pills like sildenafil (Viagra) and tadalafil (Cialis) are PDE5 inhibitors: they increase blood flow but do nothing for desire. PT-141 works upstream, activating melanocortin receptors (primarily MC4R) in the central nervous system — the signaling involved in sexual desire and arousal itself. That is why it is studied for low desire, a problem blood-flow drugs do not address.
How do I take PT-141, and how fast does it work?
Compounded PT-141 through Telos Rx is an as-needed subcutaneous (under the skin) injection taken ahead of anticipated intimacy — there is no daily pill or standing routine. Your prescribing clinician sets your exact dose and timing and adjusts it based on your response. Onset varies; many people notice an effect within a few hours of dosing. The FDA-approved labeling for bremelanotide uses a dose at least 45 minutes before anticipated activity, no more than one dose in 24 hours and no more than 8 doses per month.
How much does PT-141 cost?
Through Telos Rx, PT-141 starts at $40 for your first month on a 12-month plan ($160/month after). Shorter plans cost more per month: 6-month plans start at $99 for the first month ($180/month after), 3-month plans at $129 ($235/month after), and a single month is $249. Every plan includes the clinician consultation, unlimited care-team messaging, free 2-day shipping, and one-click cancellation. It is FSA/HSA eligible, and no insurance is needed.
What about brand-name Vyleesi?
Vyleesi is the FDA-approved auto-injector version of bremelanotide. Without insurance it typically runs over $1,000 per box of four doses at retail pharmacies. If you have commercial insurance that covers Vyleesi, ask your prescriber about it and check the manufacturer's savings program — that may be your cheapest path. For cash-pay patients, clinician-prescribed compounded PT-141 is usually far more affordable.
Is PT-141 for women, men, or both?
The FDA approval (Vyleesi) is specifically for low sexual desire (HSDD) in premenopausal women. PT-141 has also been studied in men, and clinicians may prescribe compounded PT-141 off-label for men when they judge it appropriate — particularly when the issue is desire and arousal rather than blood flow. The Telos Rx intake asks about your situation, and a licensed clinician decides whether it is a fit.
What are the side effects of PT-141?
The most common side effects are nausea (especially with the first doses), flushing, headache, and injection-site reactions; these are usually mild and dose-related. Bremelanotide can cause a temporary increase in blood pressure after each dose, so it should not be used by people with uncontrolled high blood pressure or known cardiovascular disease. Repeated use can cause focal skin darkening (hyperpigmentation), including on the face and gums, which may not fully resolve — the risk is higher with more than 8 doses per month and in people with darker skin. It can also slow stomach emptying, which may affect absorption of some oral medications (avoid combining with oral naltrexone). Report your full health history honestly during the intake.
Do I need a prescription?
Yes. PT-141 is prescription-only. You complete a short online intake, a U.S.-licensed clinician reviews it (typically within about 4 hours), and if approved, a licensed U.S. compounding pharmacy fills your prescription and ships it free in discreet packaging within about 48 hours.

Ready to address desire at the source?

Complete the 5-minute intake and a U.S.-licensed clinician will confirm whether PT-141 is right for you — typically within 4 hours.

Start Your Online Visit From $40 first month · consultation and shipping included

Medical disclaimer: Rx.com does not provide medical advice or prescribe medication. PT-141 (bremelanotide) is available only with a prescription from a licensed clinician after a health evaluation. Compounded medications are prepared by a licensed compounding pharmacy and are not FDA-approved products; the FDA-approved form of bremelanotide is Vyleesi, indicated for acquired, generalized hypoactive sexual desire disorder in premenopausal women. Product details, timing claims and pricing are provided by Telos Rx and may change. This page is for informational purposes and is not a substitute for professional medical advice.

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