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Acetazolamide Tablet — prescription drug image

Acetazolamide

acetaZOLAMIDE 250MG

What is Acetazolamide?

Acetazolamide is a generic drug used to treat patients with glaucoma; it is also used to treat patients with epilepsy and edema. The average Acetazolamide price is about $138 for a supply of 60, 250 mg tablets. However, you can use our free Rx.com coupon card to save significantly on Acetazolamide prices at a participating pharmacy near you.

Prescription savings · · · ·

What is Acetazolamide ?

Acetazolamide is a generic drug used to treat patients with glaucoma; it is also used to treat patients with epilepsy and edema. The average Acetazolamide price is about $138 for a supply of 60, 250 mg tablets. However, you can use our free Rx.com coupon card to save significantly on Acetazolamide prices at a participating pharmacy near you.
  • Unusual bleeding or bruising
  • Unusual bleeding, bruising, or weakness
  • Pain in joints or lower back
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate, lower back or side pain, painful or difficult urination
  • Confusion, drowsiness
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Trouble breathing, tiredness, uneven heartbeat
  • Tell your doctor if you are pregnant or breastfeeding, or if you have lung problems.
  • This medicine may cause the following problems:Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysisLiver problemsKidney stones
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Unusual bleeding or bruising
  • Pain in joints or lower back
What is acetazolamide used for?
It's used as an add-on treatment for certain glaucomas, for fluid retention (edema) from heart failure or other drugs, as an adjunct for some seizure types, and to help prevent or lessen acute mountain sickness symptoms during high-altitude ascent.
Is acetazolamide a diuretic?
Yes, it has a mild diuretic (water pill) effect by increasing salt and fluid elimination through the kidneys, though it's typically used as an add-on rather than a primary diuretic.
Does acetazolamide interact with aspirin?
Yes. Taking high-dose aspirin with acetazolamide has been linked to serious reactions such as severe metabolic acidosis. Tell your provider if you take aspirin regularly.
Is there a brand-name version of acetazolamide?
No. The former brand, Diamox, is no longer marketed in the U.S., so acetazolamide is available only as a generic.
How does acetazolamide help with altitude sickness?
It's used to help prevent or reduce symptoms of acute mountain sickness in people ascending quickly to high altitude, typically started before ascent on your provider's recommendation.
How much does Acetazolamide cost without insurance?
The price of Acetazolamide without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 68% off retail prices with a free Rx.com coupon.
What are the common side effects of Acetazolamide?
Common side effects of Acetazolamide may include: Unusual bleeding or bruising, Unusual bleeding, bruising, or weakness, Pain in joints or lower back, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Acetazolamide?
Generic versions may be available for Acetazolamide. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Acetazolamide on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Acetazolamide?
The cheapest pharmacy for Acetazolamide depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Acetazolamide near you.

Acetazolamide Coupons & Prices

acetaZOLAMIDE 250MG

Acetazolamide Tablet — prescription drug image
Prescription
Acetazolamide 250mg (30)
your area ·

Acetazolamide is a carbonic anhydrase inhibitor tablet prescribed for a range of uses including certain types of glaucoma, fluid retention (edema), some seizure disorders, and prevention of altitude sickness. It's only available as a generic in the U.S., and cash prices for it can vary a lot from one pharmacy to the next. Enter your ZIP above to compare an acetazolamide coupon across pharmacies near you.

What Is Acetazolamide and How Does It Work?

Acetazolamide is a sulfonamide-derivative carbonic anhydrase inhibitor. Depending on where it acts in the body, it can reduce fluid pressure in the eye (used for certain glaucomas), increase fluid and salt elimination through the kidneys (used as an add-on treatment for edema from congestive heart failure or from other drugs), help control certain seizure types as an adjunct to other seizure medicines, and reduce the fluid shifts that contribute to acute mountain sickness symptoms in people ascending to high altitude. It's taken by mouth as an immediate-release tablet, generally on a schedule your prescriber sets for your specific condition.

Why Prices Vary and How to Save

Acetazolamide is sold only as a generic; the older brand, Diamox, is no longer marketed in the U.S. Because it's a widely produced generic, cash prices can differ significantly by pharmacy, so it's worth comparing before you fill. Rx.com compares prices at more than 60,000 pharmacies to help you find a lower price near you, regardless of whether you have insurance.

Alternatives and Related Medications

For eye pressure, other options your provider may consider include methazolamide, an oral carbonic anhydrase inhibitor, or dorzolamide, a carbonic anhydrase inhibitor delivered as eye drops rather than a pill. For fluid retention, other classes of diuretics such as furosemide are sometimes used instead, though they work differently. Which option makes sense depends on your specific diagnosis, so this isn't a substitute for your prescriber's guidance.

Safety Information

Acetazolamide shouldn't be used by people with a sulfonamide allergy, low sodium or potassium levels, adrenal gland failure, severe kidney or liver disease, or certain types of acidosis, and it isn't meant for long-term use in some chronic angle-closure glaucoma. Taking high-dose aspirin together with acetazolamide has been associated with serious reactions including severe acidosis, so tell your provider about all medications you take, including aspirin. Common side effects can include tingling in the fingers/toes, taste changes, and increased urination. This is general information, not medical advice — talk with your provider about whether acetazolamide is right for you.

Sources & accuracy

This Acetazolamide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Acetazolamide on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.