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Azithromycin

Azithromycin 6 Tablets

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What is Azithromycin?

Azithromycin is a prescription macrolide antibiotic used to treat a wide range of bacterial infections including community-acquired pneumonia, bronchitis, sinus infections, strep throat, ear infections (in children), skin infections, and certain sexually transmitted infections (STIs) like chlamydia. The classic 5-day Z-Pack (azithromycin 500 mg on day 1, then 250 mg daily for 4 days) is one of the most recognized antibiotic regimens in the US. Azithromycin works by binding to the 50S ribosomal subunit of bacteria, stopping them from making the proteins they need to survive and reproduce. A key property is its very high tissue penetration — it concentrates in tissues and white blood cells at levels far exceeding plasma levels, which allows effective 5-day courses to cover infections for 7–10 days. A licensed provider can prescribe azithromycin through Rx.com for appropriate bacterial infections. Generic azithromycin is very affordable with an Rx.com coupon.

Prescription savings · · · ·

What is Azithromycin ?

Azithromycin is a prescription macrolide antibiotic used to treat a wide range of bacterial infections including community-acquired pneumonia, bronchitis, sinus infections, strep throat, ear infections (in children), skin infections, and certain sexually transmitted infections (STIs) like chlamydia. The classic 5-day Z-Pack (azithromycin 500 mg on day 1, then 250 mg daily for 4 days) is one of the most recognized antibiotic regimens in the US. Azithromycin works by binding to the 50S ribosomal subunit of bacteria, stopping them from making the proteins they need to survive and reproduce. A key property is its very high tissue penetration — it concentrates in tissues and white blood cells at levels far exceeding plasma levels, which allows effective 5-day courses to cover infections for 7–10 days. A licensed provider can prescribe azithromycin through Rx.com for appropriate bacterial infections. Generic azithromycin is very affordable with an Rx.com coupon.
  • Diarrhea
  • Nausea
  • Vomiting
  • Abdominal pain
  • Headache
  • May cause QT prolongation, which can cause irregular heartbeats
  • Can lead to severe allergic reactions, including rash, itching, swelling, and trouble breathing
  • Increased risk of Clostridium difficile-associated diarrhea
  • Potential liver dysfunction and injury
  • May exacerbate symptoms in patients with myasthenia gravis
What is azithromycin used to treat?
Azithromycin is an antibiotic used to treat many bacterial infections, including community-acquired pneumonia, worsening of chronic bronchitis or COPD, sinus infections, sore throat and tonsillitis, certain skin infections, ear infections in children, and some sexually transmitted infections such as chlamydia. It is also used to prevent and treat MAC infection in people with advanced HIV. It does not work against viruses, so it will not treat a cold or the flu.
How long does azithromycin stay in your system?
Azithromycin is known for staying in the body a long time — it lingers in tissues for days after your last dose, which is why a short course (such as a 5-day Z-Pak) can keep working after you finish the pills. Because timing varies from person to person, ask your pharmacist or prescriber if you have a specific question about your treatment.
Can you drink alcohol while taking azithromycin?
Alcohol does not stop azithromycin from working, but drinking can worsen common side effects like nausea, stomach upset, and dizziness, and it can slow your recovery. It's generally best to limit or avoid alcohol until you finish the medication and feel better. Check with your provider or pharmacist about your situation.
What are the most common side effects of azithromycin?
The most common side effects are digestive: nausea, diarrhea, stomach pain or cramping, and sometimes vomiting or headache. These are usually mild. Contact your provider if you develop a severe or watery diarrhea, a rash, trouble breathing, or an irregular heartbeat, as these can signal a more serious reaction.
Is azithromycin a strong antibiotic?
Azithromycin is an effective, broad-spectrum antibiotic that treats many types of bacterial infections, and its long-lasting action allows for short courses of treatment. Whether it is the right choice depends on the specific bacteria causing your infection — no single antibiotic is best for everything, and your prescriber selects one based on your infection and health history. It does not work against viral illnesses.
How much does Azithromycin cost without insurance?
The price of Azithromycin without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Azithromycin?
Common side effects of Azithromycin may include: Diarrhea, Nausea, Vomiting, Abdominal pain, Headache. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Azithromycin?
Generic versions may be available for Azithromycin. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Azithromycin on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Azithromycin?
The cheapest pharmacy for Azithromycin depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Azithromycin near you.

Azithromycin Coupons & Prices

Azithromycin 6 Tablets

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Azithromycin Box — prescription drug image
Prescription
Azithromycin 6 tablets (0.5)
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Looking for an azithromycin coupon? Azithromycin is the low-cost generic form of Zithromax (the "Z-Pak"), a macrolide antibiotic used to treat many common bacterial infections. Even though the generic is already inexpensive, the cash price can vary a lot from one pharmacy to the next, so it pays to compare. Enter your ZIP code above to see today's azithromycin price at pharmacies near you — Rx.com compares prices across more than 60,000 pharmacies so you can bring the lowest one to the counter.

What is azithromycin and how does it work?

Azithromycin is a macrolide antibiotic. It is FDA-approved to treat a range of bacterial infections, including community-acquired pneumonia, acute worsening of chronic bronchitis or COPD, acute bacterial sinusitis, sore throat and tonsillitis (as an alternative to first-line therapy), certain skin infections, ear infections in children, and some sexually transmitted infections such as chlamydia. It is also used to prevent and treat disseminated Mycobacterium avium complex (MAC) in people with advanced HIV.

Azithromycin works by stopping bacteria from making the proteins they need to grow and multiply. Because it targets bacteria, it does not work against viral illnesses like the common cold or the flu. Taking an antibiotic you don't need won't help you feel better and can contribute to antibiotic resistance. Azithromycin is sold under the brand names Zithromax, Z-Pak, and Zmax, and is widely available as a generic.

Azithromycin cost and savings without insurance

Azithromycin is available as a generic, which usually keeps the cost low even if you don't have insurance. That said, the cash price is not the same everywhere — different pharmacies can charge very different amounts for the exact same prescription, so comparing before you fill matters.

There is no manufacturer savings card for generic azithromycin, but a free Rx.com coupon can help you pay the lowest available cash price. Enter your ZIP above to see today's price at nearby pharmacies, then show the coupon at the counter. If your prescriber wrote for the brand-name Zithromax, ask whether the generic is appropriate for you, since it typically costs less.

Azithromycin alternatives and related antibiotics

Azithromycin is one of several antibiotics your provider may consider, depending on the type of infection and your medical history. Related and alternative options include:

Only your prescriber can decide which antibiotic is right for your infection. If you are switched to a different medication, you can compare its price on Rx.com the same way.

Important safety information

Azithromycin has no FDA boxed warning, but there are important safety points to know. The main concern is that it can affect the heart's rhythm (QT-interval prolongation), which in rare cases can lead to dangerous, even fatal, irregular heartbeats. Extra caution is needed if you have a known heart-rhythm problem, low potassium or magnesium, a slow heart rate, or take other medicines that affect the QT interval. Tell your provider and pharmacist about all medications and conditions.

Other serious but uncommon risks include severe allergic reactions (including anaphylaxis and serious skin reactions), liver problems, and diarrhea caused by C. difficile that can start even weeks to months after finishing the medicine. In young infants, azithromycin has been linked to a stomach-valve condition called pyloric stenosis. This information is not medical advice — talk with your doctor or pharmacist about your specific situation, and contact them promptly if you have a severe rash, trouble breathing, an irregular heartbeat, or persistent diarrhea.

Sources & accuracy

This Azithromycin information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Azithromycin on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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