Breztri Aerosphere
Breztri Aerosphere 10.7GM of 160-9-4.8MCG/ACT
What is Breztri Aerosphere?
Breztri Aerosphere is a prescription inhaler used to help manage chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines three medications in one inhaler to help open the airways, reduce inflammation, and improve breathing. Breztri is typically used as a long-term maintenance treatment to help reduce COPD flare-ups and improve lung function. Learn about Breztri Aerosphere uses, dosage, side effects, cost, alternatives, and how it compares to other COPD inhalers. If you need a prescription or refill on your prescription for Breztri, Rx.com can connect you with a doctor in just a few minutes.
Side Effects
- Upper respiratory tract infection
- Oral candidiasis
- Back pain
Warnings
- Risk of fungal infections in the mouth and throat
- Potential worsening of existing tuberculosis, fungal, bacterial, viral or parasitic infections
- Risk of osteoporosis and decreased bone mineral density
- Potential for glaucoma and cataracts
- Do not use for relief of acute bronchospasm or status asthmaticus
Prescription savings · · · ·
What is Breztri Aerosphere ?
Breztri Aerosphere is a prescription inhaler used to help manage chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines three medications in one inhaler to help open the airways, reduce inflammation, and improve breathing. Breztri is typically used as a long-term maintenance treatment to help reduce COPD flare-ups and improve lung function. Learn about Breztri Aerosphere uses, dosage, side effects, cost, alternatives, and how it compares to other COPD inhalers. If you need a prescription or refill on your prescription for Breztri, Rx.com can connect you with a doctor in just a few minutes.
- Upper respiratory tract infection
- Oral candidiasis
- Back pain
- Pneumonia
- Headache
- Risk of fungal infections in the mouth and throat
- Potential worsening of existing tuberculosis, fungal, bacterial, viral or parasitic infections
- Risk of osteoporosis and decreased bone mineral density
- Potential for glaucoma and cataracts
- Do not use for relief of acute bronchospasm or status asthmaticus
Breztri Aerosphere Coupon, Savings Card & Prices
Breztri Aerosphere 10.7GM of 160-9-4.8MCG/ACT
4 ED medications in one dose
Sildenafil, tadalafil, PT-141 & L-Citrulline · Works in ~15 min · Lasts up to 36 hours
Looking for a Breztri Aerosphere coupon? Rx.com offers a free cash-price coupon you can use at the pharmacy counter for Breztri Aerosphere, the brand-name triple-combination inhaler (budesonide, glycopyrrolate, and formoterol fumarate) used for long-term maintenance of COPD and asthma. There is no generic version yet, so the cash price matters. Enter your ZIP code above to see today's discounted price at pharmacies near you, and compare it against your insurance and the manufacturer's savings card to find your lowest option.
What is Breztri Aerosphere and how does it work?
Breztri Aerosphere is a metered-dose inhaler that combines three medicines in one device: an inhaled corticosteroid (ICS, budesonide) to reduce airway inflammation, a long-acting muscarinic antagonist (LAMA, glycopyrrolate), and a long-acting beta2-agonist (LABA, formoterol fumarate). The LAMA and LABA both relax and open the airways, while the corticosteroid calms swelling. It is FDA-approved for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, and its label has been expanded to include maintenance treatment of asthma in adults and children 12 years and older.
Breztri is a daily maintenance inhaler, not a rescue inhaler. It does not relieve sudden breathing problems or acute bronchospasm, so keep a fast-acting rescue inhaler on hand for those. This is general information, not medical advice; your provider decides whether Breztri is right for you.
Breztri Aerosphere cost and savings: manufacturer card vs. Rx.com cash coupon
Breztri is a brand-name inhaler with no generic equivalent, so it can be expensive without coverage. AstraZeneca offers a manufacturer savings program (the Breztri "Zero Pay" savings card) at breztri.com/savings-support/zero-pay-program. Manufacturer copay cards like this are generally limited to patients with commercial (private) insurance and typically exclude people with Medicare, Medicaid, or other government coverage. Terms, eligibility, and any dollar limits are set by the manufacturer and change over time, so check the official page for current details.
The Rx.com cash coupon works differently: it is a discount on the cash price and can be used whether or not you have insurance. That makes it a useful option if you are uninsured, on Medicare or Medicaid, or if the manufacturer card is declined or does not apply to you. You cannot combine a cash coupon with insurance on the same purchase, but you can compare both and choose whichever costs less. Enter your ZIP above to see today's Rx.com price. If cost is a barrier, ask your provider or the manufacturer about patient-assistance options as well.
Breztri alternatives and similar inhalers
Breztri belongs to the ICS/LAMA/LABA "triple therapy" class. If you and your provider are weighing options, other maintenance inhalers with overlapping uses include Trelegy Ellipta (the other single-inhaler triple therapy) and dual-combination inhalers such as Symbicort, Advair Diskus, and generic budesonide/formoterol. LAMA-based options such as Spiriva and Anoro Ellipta are also used for COPD.
These inhalers differ in their ingredients, devices, and which conditions they are approved to treat, so they are not interchangeable. One practical difference: Breztri is an aerosol (HFA) metered-dose inhaler, while some alternatives such as Trelegy Ellipta and Advair Diskus are dry-powder inhalers that contain lactose and may not suit people with a severe milk-protein allergy. Only your healthcare provider can decide which is appropriate for you. You can look up the current cash price for any of these on Rx.com to compare.
Safety and side effects
Breztri does not carry a boxed warning, but it is not for acute symptoms or rescue use. Because it contains a corticosteroid, COPD patients may have an increased risk of pneumonia, and oral thrush (candidiasis) can occur, which is why you should rinse your mouth with water without swallowing after each use. Other potential risks include paradoxical bronchospasm (sudden worsening of breathing right after a dose), cardiovascular effects, worsening of narrow-angle glaucoma, urinary retention, low potassium, high blood sugar, reduced bone mineral density, adrenal suppression, and a higher chance of certain infections. As with other long-acting beta2-agonist (LABA) medicines, the label notes that effects on heart rhythm are possible; at the approved doses, Breztri was studied and did not cause clinically meaningful QT prolongation.
Unlike some dry-powder inhalers, Breztri Aerosphere does not contain lactose, so it is not a source of milk protein. Tell your provider about all your health conditions and medicines before starting. This is not a complete list of side effects and is not medical advice; talk with your doctor or pharmacist about your specific situation, and seek care right away if breathing suddenly worsens after a dose.
This Breztri Aerosphere information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Breztri Aerosphere on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.