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Breztri Aerosphere Inhaler — prescription drug image

Breztri Aerosphere

Breztri Aerosphere 10.7GM of 160-9-4.8MCG/ACT

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What is Breztri Aerosphere?

Breztri Aerosphere is a prescription inhaler used to help manage chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines three medications in one inhaler to help open the airways, reduce inflammation, and improve breathing. Breztri is typically used as a long-term maintenance treatment to help reduce COPD flare-ups and improve lung function. Learn about Breztri Aerosphere uses, dosage, side effects, cost, alternatives, and how it compares to other COPD inhalers. If you need a prescription or refill on your prescription for Breztri, Rx.com can connect you with a doctor in just a few minutes.

Prescription savings · · · ·

What is Breztri Aerosphere ?

Breztri Aerosphere is a prescription inhaler used to help manage chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines three medications in one inhaler to help open the airways, reduce inflammation, and improve breathing. Breztri is typically used as a long-term maintenance treatment to help reduce COPD flare-ups and improve lung function. Learn about Breztri Aerosphere uses, dosage, side effects, cost, alternatives, and how it compares to other COPD inhalers. If you need a prescription or refill on your prescription for Breztri, Rx.com can connect you with a doctor in just a few minutes.

  • Upper respiratory tract infection
  • Oral candidiasis
  • Back pain
  • Pneumonia
  • Headache
  • Risk of fungal infections in the mouth and throat
  • Potential worsening of existing tuberculosis, fungal, bacterial, viral or parasitic infections
  • Risk of osteoporosis and decreased bone mineral density
  • Potential for glaucoma and cataracts
  • Do not use for relief of acute bronchospasm or status asthmaticus
What is Breztri Aerosphere used for?
Breztri Aerosphere is FDA-approved for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Its label has also been expanded to cover maintenance treatment of asthma in adults and children 12 years and older. It is a daily maintenance inhaler, not a treatment for sudden breathing problems.
Is Breztri a rescue inhaler?
No. Breztri Aerosphere is a long-acting maintenance inhaler used every day to help control COPD or asthma over time. It is not indicated for the relief of acute bronchospasm and will not stop a sudden asthma or COPD flare-up. You should keep a separate fast-acting rescue inhaler for sudden symptoms.
Is there a generic version of Breztri Aerosphere?
No. There is currently no generic version of Breztri Aerosphere; it is available only as the brand-name product. Because there is no lower-cost generic, comparing the cash price with a Rx.com coupon against your insurance and the manufacturer savings card is the main way to lower your cost.
Does Breztri Aerosphere contain lactose or milk protein?
No. Breztri Aerosphere is an aerosol (HFA) metered-dose inhaler and does not contain lactose, so it is not a source of milk protein. This is different from some dry-powder inhalers, such as Trelegy Ellipta and Advair Diskus, which do contain lactose and may not be suitable for people with a severe milk-protein allergy. Always review a medicine's ingredients with your pharmacist if you have a food allergy.
How much does Breztri Aerosphere cost without insurance?
The cash price varies by pharmacy and location and changes over time, so we do not list a fixed dollar amount. Enter your ZIP code above to see today's discounted Rx.com price near you. Because Breztri has no generic, also compare the manufacturer's savings card (generally for people with commercial insurance) to find your lowest option.
How much does Breztri Aerosphere cost without insurance?
The price of Breztri Aerosphere without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Breztri Aerosphere?
Common side effects of Breztri Aerosphere may include: Upper respiratory tract infection, Oral candidiasis, Back pain, Pneumonia, Headache. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Breztri Aerosphere?
Generic versions may be available for Breztri Aerosphere. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Breztri Aerosphere on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Breztri Aerosphere?
The cheapest pharmacy for Breztri Aerosphere depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Breztri Aerosphere near you.

Breztri Aerosphere Coupon, Savings Card & Prices

Breztri Aerosphere 10.7GM of 160-9-4.8MCG/ACT

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Breztri Aerosphere Inhaler — prescription drug image
Prescription
Breztri Aerosphere 10.7gm of 160-9-4.8mcg/act (120 inhalations) (1)
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Looking for a Breztri Aerosphere coupon? Rx.com offers a free cash-price coupon you can use at the pharmacy counter for Breztri Aerosphere, the brand-name triple-combination inhaler (budesonide, glycopyrrolate, and formoterol fumarate) used for long-term maintenance of COPD and asthma. There is no generic version yet, so the cash price matters. Enter your ZIP code above to see today's discounted price at pharmacies near you, and compare it against your insurance and the manufacturer's savings card to find your lowest option.

What is Breztri Aerosphere and how does it work?

Breztri Aerosphere is a metered-dose inhaler that combines three medicines in one device: an inhaled corticosteroid (ICS, budesonide) to reduce airway inflammation, a long-acting muscarinic antagonist (LAMA, glycopyrrolate), and a long-acting beta2-agonist (LABA, formoterol fumarate). The LAMA and LABA both relax and open the airways, while the corticosteroid calms swelling. It is FDA-approved for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, and its label has been expanded to include maintenance treatment of asthma in adults and children 12 years and older.

Breztri is a daily maintenance inhaler, not a rescue inhaler. It does not relieve sudden breathing problems or acute bronchospasm, so keep a fast-acting rescue inhaler on hand for those. This is general information, not medical advice; your provider decides whether Breztri is right for you.

Breztri Aerosphere cost and savings: manufacturer card vs. Rx.com cash coupon

Breztri is a brand-name inhaler with no generic equivalent, so it can be expensive without coverage. AstraZeneca offers a manufacturer savings program (the Breztri "Zero Pay" savings card) at breztri.com/savings-support/zero-pay-program. Manufacturer copay cards like this are generally limited to patients with commercial (private) insurance and typically exclude people with Medicare, Medicaid, or other government coverage. Terms, eligibility, and any dollar limits are set by the manufacturer and change over time, so check the official page for current details.

The Rx.com cash coupon works differently: it is a discount on the cash price and can be used whether or not you have insurance. That makes it a useful option if you are uninsured, on Medicare or Medicaid, or if the manufacturer card is declined or does not apply to you. You cannot combine a cash coupon with insurance on the same purchase, but you can compare both and choose whichever costs less. Enter your ZIP above to see today's Rx.com price. If cost is a barrier, ask your provider or the manufacturer about patient-assistance options as well.

Breztri alternatives and similar inhalers

Breztri belongs to the ICS/LAMA/LABA "triple therapy" class. If you and your provider are weighing options, other maintenance inhalers with overlapping uses include Trelegy Ellipta (the other single-inhaler triple therapy) and dual-combination inhalers such as Symbicort, Advair Diskus, and generic budesonide/formoterol. LAMA-based options such as Spiriva and Anoro Ellipta are also used for COPD.

These inhalers differ in their ingredients, devices, and which conditions they are approved to treat, so they are not interchangeable. One practical difference: Breztri is an aerosol (HFA) metered-dose inhaler, while some alternatives such as Trelegy Ellipta and Advair Diskus are dry-powder inhalers that contain lactose and may not suit people with a severe milk-protein allergy. Only your healthcare provider can decide which is appropriate for you. You can look up the current cash price for any of these on Rx.com to compare.

Safety and side effects

Breztri does not carry a boxed warning, but it is not for acute symptoms or rescue use. Because it contains a corticosteroid, COPD patients may have an increased risk of pneumonia, and oral thrush (candidiasis) can occur, which is why you should rinse your mouth with water without swallowing after each use. Other potential risks include paradoxical bronchospasm (sudden worsening of breathing right after a dose), cardiovascular effects, worsening of narrow-angle glaucoma, urinary retention, low potassium, high blood sugar, reduced bone mineral density, adrenal suppression, and a higher chance of certain infections. As with other long-acting beta2-agonist (LABA) medicines, the label notes that effects on heart rhythm are possible; at the approved doses, Breztri was studied and did not cause clinically meaningful QT prolongation.

Unlike some dry-powder inhalers, Breztri Aerosphere does not contain lactose, so it is not a source of milk protein. Tell your provider about all your health conditions and medicines before starting. This is not a complete list of side effects and is not medical advice; talk with your doctor or pharmacist about your specific situation, and seek care right away if breathing suddenly worsens after a dose.

Sources & accuracy

This Breztri Aerosphere information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Breztri Aerosphere on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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