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Cefadroxil Capsule — prescription drug image

Cefadroxil

Cefadroxil 500MG

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What is Cefadroxil?

Cefadroxil is used to treat different types of bacterial infections in the body. Cefadroxil is a generic drug. On average Cefadroxil is priced at about $51 for a supply of 20, 500 mg capsules. Luckily, you can use our Rx.com savings offer to receive a Cefadroxil discount of up to 80% off the retail price at participating pharmacies near you.

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What is Cefadroxil ?

Cefadroxil is used to treat different types of bacterial infections in the body. Cefadroxil is a generic drug. On average Cefadroxil is priced at about $51 for a supply of 20, 500 mg capsules. Luckily, you can use our Rx.com savings offer to receive a Cefadroxil discount of up to 80% off the retail price at participating pharmacies near you.
  • Blistering or peeling skin
  • Rash or hives
  • Swelling of the face, throat, or lips
  • Wheezing or trouble breathing
  • Severe diarrhea (watery or bloody)
  • Severe vomiting or stomach pain
  • Before taking this medicine, let your doctor know if you have ever had an allergic reaction to penicillin or if you have kidney disease.
  • If you have severe diarrhea while taking this medicine, check with your doctor before taking medicine to stop the diarrhea.
  • Cefadroxil may cause incorrect results with some tests used by patients with diabetes to check for sugar in urine.
  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Severe vomiting or stomach pain
  • Blistering or peeling skin
What is cefadroxil used to treat?
Cefadroxil is FDA-approved to treat infections caused by susceptible bacteria: urinary tract infections (caused by E. coli, P. mirabilis, and Klebsiella species), skin and skin structure infections (caused by staphylococci and/or streptococci), and pharyngitis and/or tonsillitis caused by Streptococcus pyogenes, the group A strep bacterium. Those three are the entire approved list. Cefadroxil is also used off-label, based on American Heart Association guidance rather than FDA approval, to help prevent a heart valve infection before dental work in some people with a penicillin allergy. It will not treat colds, the flu, or other viral infections.
Is cefadroxil the same as cephalexin (Keflex)?
No. They are two different drugs, though they are closely related. Both are first-generation cephalosporin antibiotics and they are used for overlapping types of infections, but they are not interchangeable and a pharmacist cannot substitute one for the other. One practical difference is the schedule: cefadroxil is generally taken every 12 or 24 hours, while cephalexin is usually taken more often during the day. Your prescriber chooses which one fits your infection.
Can I take cefadroxil if I am allergic to penicillin?
Only your prescriber can make that call, and the answer depends on what your penicillin reaction was. If you have ever had anaphylaxis, angioedema, or hives (urticaria) after penicillin or ampicillin, American Heart Association guidance says cephalosporins like cefadroxil should not be used at all; azithromycin, clarithromycin, or doxycycline are used instead. For milder, non-immediate penicillin allergy, a first-generation cephalosporin may be considered, and that is the basis for the off-label use of cefadroxil before dental work to help prevent a heart valve infection. Note that AHA tables name cephalexin specifically, with cefadroxil covered only under 'another first- or second-generation cephalosporin.' The prescribing information says cross-sensitivity may occur in up to 10% of penicillin-allergic patients, while more recent allergy research puts it lower, but a serious anaphylactic reaction can require epinephrine and emergency care. Cefadroxil should not be taken at all by anyone with a known cephalosporin allergy. Tell your prescriber and pharmacist about every drug allergy you have, and what the reaction was, before you start.
How long does cefadroxil take to work?
Many people begin to feel better within the first few days, but that varies with the infection and the person, and it is not a signal to stop. Finish the entire course exactly as prescribed even if you feel well, because stopping early can let the infection come back and can help bacteria become resistant. If you are not improving, or you get worse, contact your prescriber.
Should cefadroxil be taken with food?
Cefadroxil can be taken with or without food. If it upsets your stomach, taking it with food or a snack may help. Follow the directions on your prescription label and shake the oral suspension well before measuring each dose if you were given the liquid form. Ask your pharmacist if you are unsure how to take yours.
How much does Cefadroxil cost without insurance?
The price of Cefadroxil without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 69% off retail prices with a free Rx.com coupon.
What are the common side effects of Cefadroxil?
Common side effects of Cefadroxil may include: Blistering or peeling skin, Rash or hives, Swelling of the face, throat, or lips, Wheezing or trouble breathing, Severe diarrhea (watery or bloody). This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Cefadroxil?
Generic versions may be available for Cefadroxil. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Cefadroxil on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Cefadroxil?
The cheapest pharmacy for Cefadroxil depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Cefadroxil near you.

Cefadroxil Coupons & Prices

Cefadroxil 500MG

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Looking for a cefadroxil coupon? Cefadroxil is a first-generation cephalosporin antibiotic available as a generic in capsules, tablets, and oral suspension. The original brands, Duricef and Ultracef, are no longer marketed in the US, so the generic is what your pharmacy fills. Cash prices for the same prescription can differ a great deal from one pharmacy to the next, even within a few miles, which is exactly why it pays to compare. Rx.com checks prices at more than 60,000 pharmacies so you can see what cefadroxil costs near you before you go. Enter your ZIP above to see today's price and print, text, or show your free coupon at the counter.

What is cefadroxil and how does it work?

Cefadroxil is a first-generation cephalosporin antibiotic. It works against bacteria that are susceptible to it, and it does nothing for colds, the flu, or other viral infections. Using an antibiotic when it is not needed only helps bacteria become resistant to it later.

The FDA-approved uses for oral cefadroxil are infections caused by susceptible bacteria:

  • Urinary tract infections caused by E. coli, P. mirabilis, and Klebsiella species
  • Skin and skin structure infections caused by staphylococci and/or streptococci
  • Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (group A strep)

It comes as capsules, tablets, and an oral suspension, and is usually taken every 12 or 24 hours, with or without food. Those three uses are the complete FDA-approved list for cefadroxil. Preventing a heart valve infection (infective endocarditis) before dental work is not an FDA-approved use of cefadroxil; it is an off-label, guideline-based use. American Heart Association guidance names cephalexin as the oral cephalosporin option for people with a penicillin or amoxicillin allergy, and allows "another first- or second-generation cephalosporin" in an equivalent dose, which is where cefadroxil can fit. Importantly, that same guidance says cephalosporins should not be used at all in anyone with a history of anaphylaxis, angioedema, or hives (urticaria) after penicillin or ampicillin; those patients are given azithromycin, clarithromycin, or doxycycline instead. Your prescriber decides which use, dose, and length of treatment fit your situation.

What cefadroxil costs without insurance, and how to compare

Cefadroxil is only sold as a generic in the US, and there is no manufacturer savings card for it. That does not mean every pharmacy charges the same thing. Cash prices for an identical quantity and strength can vary widely by pharmacy and by ZIP code, so the pharmacy closest to you is not automatically the cheapest one.

If you are paying cash, or if your plan's copay is higher than the cash price, a free Rx.com coupon can be used instead of insurance. Enter your ZIP above to see today's price at pharmacies near you, then bring the coupon to the counter. Because a course of an antibiotic is usually short, it is worth checking the price before you drop the prescription off rather than after. You cannot combine a discount coupon with your insurance on the same fill, so ask the pharmacist to run whichever comes out lower for you.

Cefadroxil vs. other cephalosporins and antibiotic alternatives

Cefadroxil is closely related to cephalexin (Keflex), the other widely used first-generation oral cephalosporin. They are not the same drug, and they are not interchangeable at the pharmacy, but they are used for overlapping types of infections. One practical difference is dosing schedule: cefadroxil is taken every 12 or 24 hours, while cephalexin is typically taken more often through the day.

Other oral options a prescriber may consider, depending on the infection and on your allergy history, include the second-generation cephalosporins cefuroxime and cefprozil, the third-generation cefdinir, and the penicillin-class antibiotic amoxicillin. Only your prescriber can choose the right antibiotic for the bacteria involved. If you have been prescribed one of these instead, you can look up and compare its price on Rx.com the same way.

Safety information you should know

Cefadroxil has no boxed warning. It should not be taken by anyone with a known allergy to cephalosporins. The cefadroxil prescribing information states that cross-sensitivity among beta-lactam antibiotics has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy; more recent allergy research suggests the true rate is lower, often cited around 1% to 2% for cephalosporins whose chemical side chains differ from the penicillin involved. Either way, a serious anaphylactic reaction can require epinephrine and emergency care, so tell your prescriber and pharmacist about any drug allergy before you start, and describe what the reaction actually was. Cephalosporins are not an option at all for people who have had anaphylaxis, angioedema, or hives from penicillin or ampicillin. Antibiotics including cefadroxil have been linked to Clostridioides difficile-associated diarrhea, which can range from mild diarrhea to fatal colitis and has been reported to begin even two months or more after you finish the medicine, so do not dismiss watery or bloody stools just because the course ended a while ago.

Because more than 90% of the drug leaves the body unchanged in the urine, people with markedly impaired kidney function (creatinine clearance under 50 mL/min/1.73 m2) need a dose adjustment and should use cefadroxil with caution. If you have diabetes and test your urine for glucose, use an enzyme-based test such as Clinistix or TesTape rather than Clinitest, since cefadroxil can affect the result. Call your prescriber about watery or bloody stools, a rash, trouble breathing, swelling, or yellowing of the skin or eyes. This is a summary, not medical advice, and not a complete list of risks. Read the information that comes with your prescription and talk with your prescriber or pharmacist about your own situation.

Sources & accuracy

This Cefadroxil information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Cefadroxil on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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