Clindamycin Phosphate
Clindamycin Phosphate
What is Clindamycin Phosphate?
Clindamycin Topical (Evoclin) is a prescription topical antibiotic used to treat acne vulgaris. It helps reduce acne-causing bacteria and inflammation, making it effective for treating pimples, red bumps, and other inflammatory acne lesions.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Stomach pain or upset
- Severe diarrhea (watery or bloody)
Warnings
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have any allergies.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
Prescription savings · · · ·
What is Clindamycin Phosphate ?
Clindamycin Topical (Evoclin) is a prescription topical antibiotic used to treat acne vulgaris. It helps reduce acne-causing bacteria and inflammation, making it effective for treating pimples, red bumps, and other inflammatory acne lesions.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Stomach pain or upset
- Severe diarrhea (watery or bloody)
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have any allergies.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
Clindamycin Phosphate Coupons & Prices
Clindamycin Phosphate
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a clindamycin phosphate coupon? Clindamycin phosphate is a widely used generic lincosamide antibiotic sold under brand names like Cleocin, Cleocin T, Clindagel, ClindaMax, and Evoclin. Because it is generic, it is already one of the lower-cost prescription antibiotics, but the cash price can vary a lot from one pharmacy to the next, so comparing before you fill genuinely matters. Rx.com compares prices across more than 60,000 U.S. pharmacies and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you.
What is clindamycin phosphate and how does it work?
Clindamycin phosphate is the prodrug ester of clindamycin, a lincosamide antibiotic that is active against many anaerobic and gram-positive bacteria. Once absorbed, the body converts it to active clindamycin, which stops bacteria from making the proteins they need to grow. The FDA-approved use depends on the formulation:
- Topical solution, gel, lotion, foam, and pledgets (1% or 1.2%) are approved for acne vulgaris, and are often paired with benzoyl peroxide or a retinoid.
- Vaginal cream and suppositories (Cleocin) treat bacterial vaginosis.
- Injectable/IV clindamycin phosphate is used in the hospital for serious anaerobic, streptococcal, pneumococcal, and staphylococcal infections.
This is general information, not medical advice. Your prescriber will choose the form and strength that fits your condition.
Clindamycin phosphate cost and how to save
Clindamycin phosphate is available as an FDA-approved generic, so it is usually far cheaper than the original brands. Even so, there is no single set price. What you pay out of pocket without insurance depends on the formulation (topical gel, foam, lotion, vaginal cream, or injectable), the package size, and which pharmacy you use, and those cash prices can differ widely across town for the exact same product. That is why comparing pharmacies is worth the few seconds it takes.
There is no manufacturer savings card for generic clindamycin phosphate. Instead, you can use a free Rx.com discount coupon, which works at the pharmacy counter for the cash price and does not require insurance. Enter your ZIP above to see today's price at pharmacies near you and bring the coupon with you.
Brand versions and acne alternatives
Clindamycin phosphate is the generic behind topical brands such as Cleocin T, Clindagel, ClindaMax, and Evoclin, and the vaginal and injectable brand Cleocin. The generic is substitutable, so most people do fine on it. You can also compare the plain oral/topical clindamycin listing.
For acne, your prescriber may consider clindamycin as part of a combination or alongside other topicals. Related options you can price and read about include:
- clindamycin-benzoyl peroxide and standalone benzoyl peroxide
- Topical retinoids such as tretinoin and adapalene
- topical erythromycin and the oral antibiotic doxycycline
Which one is right depends on your skin and history, so talk with your provider before switching.
Safety and side effects to know
The most important safety issue with clindamycin is its effect on the gut. The oral and injectable forms carry an FDA boxed warning about Clostridioides difficile-associated diarrhea and severe, potentially fatal pseudomembranous colitis, and colitis has also been reported with topical and vaginal use. If you develop significant or persistent diarrhea during or after treatment, contact your provider promptly and do not just wait it out. Clindamycin should not be used by people who have had a hypersensitivity reaction to clindamycin or lincomycin, or who have a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.
Topical formulations can be absorbed into the body. Other reported risks include allergic reactions up to anaphylaxis, rare but serious skin reactions such as DRESS and SJS/TEN, dryness or irritation where the topical is applied, and, with rapid IV injection, cardiopulmonary reactions. This is not a complete list. Review the full label and ask your pharmacist or prescriber about your own situation.
This Clindamycin Phosphate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Clindamycin Phosphate on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.