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Clindamycin Phosphate

Clindamycin Phosphate

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What is Clindamycin Phosphate?

Clindamycin Topical (Evoclin) is a prescription topical antibiotic used to treat acne vulgaris. It helps reduce acne-causing bacteria and inflammation, making it effective for treating pimples, red bumps, and other inflammatory acne lesions.

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What is Clindamycin Phosphate ?

Clindamycin Topical (Evoclin) is a prescription topical antibiotic used to treat acne vulgaris. It helps reduce acne-causing bacteria and inflammation, making it effective for treating pimples, red bumps, and other inflammatory acne lesions.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Stomach pain or upset
  • Severe diarrhea (watery or bloody)
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have any allergies.
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
What is clindamycin phosphate used to treat?
It depends on the form. Topical clindamycin phosphate (gel, solution, lotion, foam, pledgets) is FDA-approved for acne vulgaris. The vaginal cream and suppositories treat bacterial vaginosis. The injectable/IV form treats serious bacterial infections in the hospital, including certain anaerobic, streptococcal, pneumococcal, and staphylococcal infections.
Is clindamycin phosphate an antibiotic?
Yes. Clindamycin phosphate is a lincosamide antibiotic. It is the prodrug ester of clindamycin, which your body converts to the active form. It works by blocking bacteria from making proteins, which stops them from multiplying.
How long does clindamycin phosphate take to work on acne?
Topical acne treatments generally take time. Many people start to notice improvement over several weeks of consistent daily use, and fuller results can take a couple of months. Keep using it as prescribed even if you do not see immediate change, and check with your prescriber if there is no improvement after the time they suggested.
What are the most common side effects of clindamycin phosphate?
With topical use, the most common effects are dryness, irritation, redness, burning, or peeling where it is applied. Across all forms, diarrhea can occur and should be reported to your provider because clindamycin can rarely cause severe C. difficile-related colitis. Allergic reactions and, rarely, serious skin reactions are also possible.
Can you use clindamycin phosphate topical gel every day?
Topical clindamycin for acne is typically applied on a daily schedule, and some products are once daily while others are twice daily. Follow the exact directions on your prescription and label, apply only to affected skin, and ask your prescriber or pharmacist if you are unsure how often to use your specific product.
How much does Clindamycin Phosphate 60ML of 1% cost without insurance?
The price of Clindamycin Phosphate 60ML of 1% without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Clindamycin Phosphate 60ML of 1%?
Common side effects of Clindamycin Phosphate 60ML of 1% may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Stomach pain or upset, Severe diarrhea (watery or bloody). This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Clindamycin Phosphate 60ML of 1%?
Generic versions may be available for Clindamycin Phosphate 60ML of 1%. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Clindamycin Phosphate 60ML of 1% on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Clindamycin Phosphate 60ML of 1%?
The cheapest pharmacy for Clindamycin Phosphate 60ML of 1% depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Clindamycin Phosphate 60ML of 1% near you.

Clindamycin Phosphate Coupons & Prices

Clindamycin Phosphate

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Clindamycin Phosphate Bottle — prescription drug image
Prescription
Clindamycin Phosphate 30ml of 1% (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a clindamycin phosphate coupon? Clindamycin phosphate is a widely used generic lincosamide antibiotic sold under brand names like Cleocin, Cleocin T, Clindagel, ClindaMax, and Evoclin. Because it is generic, it is already one of the lower-cost prescription antibiotics, but the cash price can vary a lot from one pharmacy to the next, so comparing before you fill genuinely matters. Rx.com compares prices across more than 60,000 U.S. pharmacies and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you.

What is clindamycin phosphate and how does it work?

Clindamycin phosphate is the prodrug ester of clindamycin, a lincosamide antibiotic that is active against many anaerobic and gram-positive bacteria. Once absorbed, the body converts it to active clindamycin, which stops bacteria from making the proteins they need to grow. The FDA-approved use depends on the formulation:

  • Topical solution, gel, lotion, foam, and pledgets (1% or 1.2%) are approved for acne vulgaris, and are often paired with benzoyl peroxide or a retinoid.
  • Vaginal cream and suppositories (Cleocin) treat bacterial vaginosis.
  • Injectable/IV clindamycin phosphate is used in the hospital for serious anaerobic, streptococcal, pneumococcal, and staphylococcal infections.

This is general information, not medical advice. Your prescriber will choose the form and strength that fits your condition.

Clindamycin phosphate cost and how to save

Clindamycin phosphate is available as an FDA-approved generic, so it is usually far cheaper than the original brands. Even so, there is no single set price. What you pay out of pocket without insurance depends on the formulation (topical gel, foam, lotion, vaginal cream, or injectable), the package size, and which pharmacy you use, and those cash prices can differ widely across town for the exact same product. That is why comparing pharmacies is worth the few seconds it takes.

There is no manufacturer savings card for generic clindamycin phosphate. Instead, you can use a free Rx.com discount coupon, which works at the pharmacy counter for the cash price and does not require insurance. Enter your ZIP above to see today's price at pharmacies near you and bring the coupon with you.

Brand versions and acne alternatives

Clindamycin phosphate is the generic behind topical brands such as Cleocin T, Clindagel, ClindaMax, and Evoclin, and the vaginal and injectable brand Cleocin. The generic is substitutable, so most people do fine on it. You can also compare the plain oral/topical clindamycin listing.

For acne, your prescriber may consider clindamycin as part of a combination or alongside other topicals. Related options you can price and read about include:

Which one is right depends on your skin and history, so talk with your provider before switching.

Safety and side effects to know

The most important safety issue with clindamycin is its effect on the gut. The oral and injectable forms carry an FDA boxed warning about Clostridioides difficile-associated diarrhea and severe, potentially fatal pseudomembranous colitis, and colitis has also been reported with topical and vaginal use. If you develop significant or persistent diarrhea during or after treatment, contact your provider promptly and do not just wait it out. Clindamycin should not be used by people who have had a hypersensitivity reaction to clindamycin or lincomycin, or who have a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.

Topical formulations can be absorbed into the body. Other reported risks include allergic reactions up to anaphylaxis, rare but serious skin reactions such as DRESS and SJS/TEN, dryness or irritation where the topical is applied, and, with rapid IV injection, cardiopulmonary reactions. This is not a complete list. Review the full label and ask your pharmacist or prescriber about your own situation.

Sources & accuracy

This Clindamycin Phosphate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Clindamycin Phosphate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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