Difluprednate
Difluprednate 5ML of 0.05%
What is Difluprednate?
Difluprednate is a potent corticosteroid used primarily as an ophthalmic emulsion to treat inflammation and pain associated with ocular surgery. This medication works by suppressing immune responses and reducing inflammation, effectively managing symptoms such as redness, swelling, and discomfort. Its powerful action makes it suitable for short-term use under close medical supervision to minimize potential side effects.Side Effects
- Blurred vision, changes in vision
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Increased discharge, redness, or irritation in your eye
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, cataracts, or an eye infection. Tell your doctor if you had recent eye surgery.
- This medicine may cause the following problems: Increased pressure in your eye, which can damage the optic nervePosterior subcapsular cataracts (a rare type of cataract)New or worsening eye infectionsSlow or delayed healing after cataract surgery
- Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
- Call your doctor if your symptoms do not improve or if they get worse.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Prescription savings · · · ·
What is Difluprednate ?
Difluprednate is a potent corticosteroid used primarily as an ophthalmic emulsion to treat inflammation and pain associated with ocular surgery. This medication works by suppressing immune responses and reducing inflammation, effectively managing symptoms such as redness, swelling, and discomfort. Its powerful action makes it suitable for short-term use under close medical supervision to minimize potential side effects.- Blurred vision, changes in vision
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Increased discharge, redness, or irritation in your eye
- Eye pain
- Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, cataracts, or an eye infection. Tell your doctor if you had recent eye surgery.
- This medicine may cause the following problems: Increased pressure in your eye, which can damage the optic nervePosterior subcapsular cataracts (a rare type of cataract)New or worsening eye infectionsSlow or delayed healing after cataract surgery
- Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
- Call your doctor if your symptoms do not improve or if they get worse.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Difluprednate Coupons & Prices
Difluprednate 5ML of 0.05%
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
A difluprednate coupon from Rx.com can lower what you pay at the pharmacy counter for difluprednate ophthalmic emulsion 0.05%, the generic form of Durezol. Difluprednate is a prescription steroid eye drop used to treat inflammation and pain after eye surgery and to treat endogenous anterior uveitis. Cash prices for this drop vary widely from one pharmacy to the next, even within the same town, so it pays to compare before you fill. Rx.com compares prices across more than 60,000 pharmacies. Enter your ZIP above to see today's price near you.
What is difluprednate and how does it work?
Difluprednate is a topical ophthalmic corticosteroid, a difluorinated derivative of prednisolone. It is supplied as an eye drop emulsion and works by calming the inflammation inside and on the surface of the eye. The brand name version is Durezol; difluprednate is the generic name for the same medicine.
The FDA has approved difluprednate ophthalmic emulsion for two uses: treating inflammation and pain associated with ocular surgery, and treating endogenous anterior uveitis. A typical post-surgery regimen is one drop in the affected eye four times daily beginning 24 hours after surgery for two weeks, then twice daily for one week, then tapering as directed. For endogenous anterior uveitis, the label describes one drop four times daily for 14 days, followed by a taper. Your eye doctor sets the exact schedule for you, so follow their instructions rather than a general guide.
What difluprednate costs without insurance, and how to pay less
Difluprednate is dispensed as a small bottle of emulsion, and the cash price without insurance can differ a great deal depending on which pharmacy you walk into. Two pharmacies a few miles apart can quote very different numbers for the identical bottle, because each sets its own cash price. That is exactly why comparing matters more here than for many other prescriptions, and it is the single easiest way to bring your cost down.
A generic difluprednate is available, and an Rx.com discount card is free to use with no insurance required. Enter your ZIP code above to see today's price at pharmacies near you, then show the coupon at the counter. If your prescription is written for brand-name Durezol, ask your prescriber or pharmacist whether the generic is appropriate for you, since the two are often priced differently. Novartis, the maker of Durezol, runs its own official website where any brand-specific support programs would be listed; eligibility and terms vary and change over time, so check directly with them.
Difluprednate compared with other steroid eye drops
Difluprednate is one of several prescription corticosteroid eye drops. Others your eye doctor may consider include prednisolone acetate (brand names include Pred Forte and Omnipred), loteprednol (brand name Lotemax), dexamethasone, and fluorometholone. These differ in potency, in how they are formulated, and in how often they are dosed.
They are not interchangeable, and only your eye doctor can decide which one fits your condition. Difluprednate's emulsion vehicle and potency are reasons it is sometimes chosen for stronger inflammation. If cost is a concern, tell your prescriber before you leave the office. It is easier to discuss an alternative then than after the prescription is already at the pharmacy. Whichever drop you are prescribed, compare prices before filling.
Safety information you should know
Difluprednate ophthalmic emulsion has no boxed warning. Prolonged use of a corticosteroid eye drop can raise the pressure inside the eye and lead to glaucoma with damage to the optic nerve and defects in visual field and sharpness of vision. Because of this, eye pressure should be monitored if the drops are used for 10 days or longer, including in children. Long-term use may also cause posterior subcapsular cataracts. Steroid drops delay wound healing after cataract surgery and may increase bleb formation. In diseases that cause thinning of the cornea or sclera, perforation has occurred.
Difluprednate should not be used in active untreated viral eye infections such as herpes simplex keratitis, vaccinia, or varicella, or in mycobacterial or fungal eye infections. Steroids can mask or worsen an infection, and fungal invasion should be suspected if a corneal ulcer will not heal. Ocular reactions reported in 5 to 15 percent of patients include corneal edema, ciliary and conjunctival redness, eye pain, light sensitivity, clouding of the posterior capsule, cells and flare in the anterior chamber, conjunctival swelling, and blepharitis. Remove contact lenses before instilling the drop, since the preservative sorbic acid can be absorbed by soft lenses; lenses may be put back in 10 minutes later. Keep the dropper tip from touching any surface, and space other eye drops at least 10 minutes apart. This is general information, not medical advice. Talk with your eye doctor or pharmacist about your own situation.
This Difluprednate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Difluprednate on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.