Doxylamine-Pyridoxine Coupons & Prices

Use a free Rx.com doxylamine-pyridoxine coupon to compare cash prices on doxylamine succinate and pyridoxine hydrochloride at more than 60,000 pharmacies near you. This prescription combination of an antihistamine and a vitamin B6 analog is the only FDA-approved medicine for nausea and vomiting of pregnancy, and it is sold under the brand names Diclegis (delayed-release 10 mg/10 mg) and Bonjesta (extended-release 20 mg/20 mg). A substitutable generic of the delayed-release tablet is available. Cash prices vary a lot from pharmacy to pharmacy, so enter your ZIP code above to see today's price at pharmacies close to you.

What is doxylamine-pyridoxine and how does it work?

Doxylamine succinate and pyridoxine hydrochloride is a fixed-dose combination tablet. Doxylamine is a first-generation ethanolamine H1 antihistamine, and pyridoxine is a form of vitamin B6. Together they are FDA-approved to treat nausea and vomiting of pregnancy, often called morning sickness, in women who have not gotten enough relief from conservative steps such as diet and lifestyle changes. It is the only FDA-approved medicine for this use, and the American College of Obstetricians and Gynecologists recommends it as the first-line drug treatment. It has not been studied in hyperemesis gravidarum, the severe form of pregnancy nausea.

The tablets are made to release the medicine slowly, so they are taken on a set daily schedule rather than only when nausea strikes. They must be swallowed whole, never crushed, chewed, or split, and taken on an empty stomach. Taking a dose with food delays how quickly it starts working and can make it less effective. Your prescriber will tell you exactly how many tablets to take and when. This page is general information, not medical advice.

How much does doxylamine-pyridoxine cost without insurance?

Cash prices for doxylamine-pyridoxine vary by pharmacy, and the same generic delayed-release tablet can be priced very differently at a chain drugstore, a grocery pharmacy, and an independent down the street. That is why it is worth comparing before you fill. Rx.com checks prices at more than 60,000 pharmacies and shows you a free coupon you can hand to the pharmacist. There is no membership or sign-up required to use it.

If you have no prescription coverage, or your plan does not cover this drug, the cash price with a coupon is often the simplest path. A few things to know: coupons are for cash-paying patients and cannot be combined with insurance on the same fill; prices for brand Diclegis, brand Bonjesta, and the generic delayed-release tablet all differ, so compare each one and ask your prescriber whether the generic is right for you; and any brand-side savings programs from the manufacturer, Duchesnay USA, are described on the manufacturer's own official website, with eligibility and terms that vary and can change. To see what you would pay today, enter your ZIP above.

Diclegis, Bonjesta, and other options

The two brand versions differ mainly in strength and release. Diclegis is a delayed-release tablet with 10 mg of doxylamine and 10 mg of pyridoxine, usually taken on a multi-dose daily schedule. Bonjesta is an extended-release tablet with 20 mg of each; the label starts it at one tablet at bedtime, and if symptoms persist the dose can be increased up to a maximum of two tablets daily, one in the morning and one at bedtime. Both are made by Duchesnay USA. In Canada the same combination is sold as Diclectin. Bendectin, the 1970s and 1980s predecessor product, is no longer marketed in the United States.

Some clinicians suggest taking over-the-counter doxylamine along with a separate vitamin B6 tablet as an alternative approach with the same two ingredients. That is a common practice rather than an FDA-approved product, and the doses and timing are not identical to the prescription tablet, so it is a conversation to have with your obstetric provider before you try it. Other antiemetics such as ondansetron, promethazine, and metoclopramide are not FDA-approved for nausea and vomiting of pregnancy; only your prescriber can decide whether any of them fits your situation.

Safety, side effects, and interactions

Doxylamine-pyridoxine does not carry a boxed warning, and extensive pregnancy safety data have not shown an increased risk of birth defects. The most common side effect is drowsiness. Do not drive or operate machinery until you know how the medicine affects you. Drinking alcohol or taking other central nervous system depressants, such as sedatives, hypnotics, tranquilizers, or opioids, is not recommended while on this medicine because the combination can cause severe drowsiness, falls, and accidents.

Other important points to review with your provider:

• It is contraindicated with monoamine oxidase inhibitors (MAOIs), which intensify and prolong the adverse central nervous system effects of this medicine, and in anyone allergic to doxylamine, other ethanolamine derivative antihistamines, pyridoxine, or any inactive ingredient in the tablet.
• Use it cautiously if you have increased intraocular pressure, narrow-angle glaucoma, a stenosing peptic ulcer, pyloroduodenal obstruction, or urinary bladder-neck obstruction.
• The label says women should not breastfeed while using it, because doxylamine passes into breast milk. Excitement, irritability, and sedation have been reported in nursing infants presumably exposed through breast milk, and infants who already have apnea or other respiratory syndromes may be especially vulnerable to its sedative effects, which can worsen their apnea or respiratory condition.
• Overdose can cause serious anticholinergic toxicity, including in children, so keep tablets out of reach. The medicine can also cause false-positive urine drug screens for methadone, opiates, or PCP.

This is a summary, not medical advice, and it does not replace the full prescribing information. Talk with your obstetric provider or pharmacist about your own history and medicines.