Entresto Coupons & Prices

Looking for an Entresto coupon? Entresto (sacubitril/valsartan) is a brand-name heart-failure medication, and the cash price varies a lot from pharmacy to pharmacy. The Rx.com coupon is a free cash-price discount you can use at the pharmacy counter even if you are uninsured, on Medicare, or if a manufacturer card was declined. Enter your ZIP above to see today's price at pharmacies near you and print or text yourself the coupon.

What is Entresto and how does it work?

Entresto is a combination of two medicines, sacubitril and valsartan, in a class called an angiotensin receptor-neprilysin inhibitor (ARNI). Sacubitril is a neprilysin inhibitor and valsartan is an angiotensin II receptor blocker (ARB). Together they relax blood vessels and help the body clear extra salt and fluid, which eases the workload on a weakened heart. It is FDA-approved to lower the risk of cardiovascular death and hospitalization in adults with chronic heart failure, with the clearest benefit in patients with reduced ejection fraction (HFrEF). The label was later expanded across the ejection-fraction spectrum, so it is also used in some patients with preserved ejection fraction (HFpEF). It is also approved for symptomatic heart failure with left ventricular systolic dysfunction in children 1 year and older. Doctors typically prescribe it in place of an ACE inhibitor or ARB.

Entresto cost: manufacturer savings card vs. Rx.com cash coupon

The manufacturer, Novartis, runs an official Entresto savings program (described on the brand's own website, with terms that vary and change over time). Programs like this are generally limited to people with commercial or private insurance and typically exclude anyone with Medicare, Medicaid, or other government coverage. If that describes you, or if the card is declined at the counter, the Rx.com cash coupon is a straightforward alternative. It is free, requires no insurance, and works for the uninsured and for many Medicare patients who are paying cash. If cost is a hardship, ask your doctor's office about the manufacturer's patient-assistance program, which may help qualifying patients who are uninsured.

The single biggest way to cut cost is the generic. A generic version of sacubitril/valsartan is now available and usually costs far less than the brand. Ask your prescriber or pharmacist whether the generic is right for you, then check the generic sacubitril/valsartan price. To compare, enter your ZIP above to see today's cash price on both the brand and the generic at pharmacies near you.

Alternatives and related heart medications

Entresto is often used instead of an older ACE inhibitor or ARB. Related medicines your doctor may consider as part of a heart-failure regimen include sacubitril/valsartan (the generic of Entresto), the ARB valsartan, the ACE inhibitor lisinopril, the ARB losartan, the beta blocker carvedilol, and the aldosterone blocker spironolactone. These are not interchangeable, and heart-failure treatment is usually a combination tailored to you. This page is for price information only and is not medical advice, so any change to your regimen should come from your prescriber.

Safety, warnings, and what to discuss with your doctor

Entresto carries a boxed warning for fetal toxicity: it can harm or cause death to a developing baby, so it should be stopped as soon as pregnancy is detected. Do not take Entresto within 36 hours of an ACE inhibitor, because combining them raises the risk of angioedema (serious swelling). It should not be used by people who have had angioedema from a prior ACE inhibitor or ARB, and it should not be combined with aliskiren in people with diabetes. Angioedema is more common in Black patients and in anyone with a history of it.

Other important risks include low blood pressure, high potassium (hyperkalemia), and reduced kidney function, so your doctor will typically monitor your blood pressure, potassium, and kidney tests. This is a summary, not medical advice. Tell your provider about all the medicines you take, and call your doctor right away if you have swelling of the face, lips, tongue, or throat, or trouble breathing.