Ketoconazole
Ketoconazole
What is Ketoconazole?
Prescription ketoconazole is an antifungal medication available as oral tablets and topical formulations (cream, foam, shampoo) used to treat fungal infections including tinea infections (ringworm, athlete's foot, jock itch), seborrheic dermatitis, pityriasis versicolor, and certain systemic fungal infections. The oral form is reserved for serious fungal infections where other antifungals cannot be used, due to liver toxicity risk. Topical ketoconazole is the most commonly used form. Ketoconazole works by blocking the synthesis of ergosterol — a critical component of the fungal cell membrane — disrupting the membrane and killing or inhibiting fungal growth. Prescription-strength topical formulations (2% cream) are more potent than OTC versions. A licensed provider can prescribe topical ketoconazole through Rx.com for seborrheic dermatitis, tinea infections, or other fungal conditions.
Side Effects
- Itching, rash, swelling, or redness that was not there before you used this medicine
- Dry or oily hair (with shampoo use)
Warnings
- If you are pregnant (or may become pregnant) or breastfeeding, talk to your doctor before using this medicine.
- If your symptoms do not get better after about a week, or get worse while using this medicine, call your doctor.
- Antifungal shampoo may remove the curls from hair that has been treated with a permanent.
- The liquid and spray forms of this medicine might be flammable. Keep them away from high heat and open flames at all times.
- Each antifungal medicine was made to treat a certain kind of infection. Use only the medicine your doctor has prescribed. You should not use an over-the-counter product in place of what your doctor has told you to use.
Prescription savings · · · ·
What is Ketoconazole ?
Prescription ketoconazole is an antifungal medication available as oral tablets and topical formulations (cream, foam, shampoo) used to treat fungal infections including tinea infections (ringworm, athlete's foot, jock itch), seborrheic dermatitis, pityriasis versicolor, and certain systemic fungal infections. The oral form is reserved for serious fungal infections where other antifungals cannot be used, due to liver toxicity risk. Topical ketoconazole is the most commonly used form. Ketoconazole works by blocking the synthesis of ergosterol — a critical component of the fungal cell membrane — disrupting the membrane and killing or inhibiting fungal growth. Prescription-strength topical formulations (2% cream) are more potent than OTC versions. A licensed provider can prescribe topical ketoconazole through Rx.com for seborrheic dermatitis, tinea infections, or other fungal conditions.
- Itching, rash, swelling, or redness that was not there before you used this medicine
- Dry or oily hair (with shampoo use)
- If you are pregnant (or may become pregnant) or breastfeeding, talk to your doctor before using this medicine.
- If your symptoms do not get better after about a week, or get worse while using this medicine, call your doctor.
- Antifungal shampoo may remove the curls from hair that has been treated with a permanent.
- The liquid and spray forms of this medicine might be flammable. Keep them away from high heat and open flames at all times.
- Each antifungal medicine was made to treat a certain kind of infection. Use only the medicine your doctor has prescribed. You should not use an over-the-counter product in place of what your doctor has told you to use.
Ketoconazole Coupons & Prices
Ketoconazole
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Ketoconazole prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 5gm of · Bottle | 5 | $37.69 | $32.55 |
| 10gm of · Bottle | 60 | $1,877.89 | $1,538.02 |
| 25gm of · Bottle | 60 | — | $279.72 |
| 30 tablets · Bottle | 84 | — | $52.48 |
| 100gm of · Bottle | 60 | — | $1,538.02 |
| 100 tablets · Bottle | 10 | — | $9.68 |
| 120ml of 2% · Bottle | 120 | $33.49 | $11.87 |
| 500gm of · Bottle | 500 | $5,057.69 | $4,973.31 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a ketoconazole coupon? Ketoconazole is an azole (imidazole) antifungal available as an affordable generic, so you do not need to overpay. Cash prices for the generic still vary widely from one pharmacy to the next, which is exactly why comparing matters. Rx.com compares prices across 60,000+ U.S. pharmacies so you can find a low price near you. Enter your ZIP above to see today's price on ketoconazole and print or show your free coupon at the pharmacy.
What is ketoconazole and how does it work?
Ketoconazole is an antifungal medicine in the azole (imidazole) class. It works by interfering with the fungal cell membrane, which stops the fungus from growing. It comes in two very different kinds of products. Oral tablets are FDA-approved only to treat certain serious systemic (endemic) fungal infections — blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis — and only when other effective antifungals cannot be used or tolerated, because of serious liver and heart risks. The oral tablets are not indicated for skin or nail infections, ordinary Candida infections, or fungal meningitis.
Topical formulations — 2% cream, 2% and OTC 1% shampoo, foam, and gel — are used on the skin or scalp for seborrheic dermatitis, dandruff, tinea (ringworm, jock itch, athlete's foot), tinea versicolor, and cutaneous candidiasis. Ketoconazole is sold under brand names including Nizoral, Nizoral A-D (the OTC shampoo), Extina, Xolegel, Ketodan, and Kuric.
Ketoconazole cost without insurance and how to save
Ketoconazole is available as a generic, so it is generally already low-cost compared with brand-name antifungals. Even so, the cash price for the same prescription can differ a lot depending on which pharmacy you use and which formulation (tablet, cream, shampoo, foam, or gel) you are filling. That price spread is the reason it pays to compare before you fill.
With or without insurance, a Rx.com coupon is free to use and can be lower than your insurance copay in some cases. Enter your ZIP above to see today's price at pharmacies near you, then show or print the coupon at the counter. Note that the 1% shampoo (Nizoral A-D) is sold over the counter and may not need a prescription or coupon at all.
Ketoconazole vs. other antifungals
Ketoconazole is one of several antifungals, and the right choice depends on the type of infection and where it is. Your prescriber may consider alternatives such as fluconazole or itraconazole (other azole antifungals often used for systemic or yeast infections), terbinafine or griseofulvin (commonly used for nail and skin fungal infections), and topical clotrimazole for many skin infections.
If you were prescribed a brand-name version, the branded shampoo and other products are sold as Nizoral. Because the generic is available, comparing the generic price across pharmacies is usually the most affordable route. This is general information, not a recommendation — your prescriber will choose the medicine that fits your infection.
Ketoconazole safety and warnings
Oral ketoconazole tablets carry an FDA boxed warning. Serious and sometimes fatal liver injury (hepatotoxicity) can occur, even in people with no prior liver disease, and in some cases has required a liver transplant. The oral form can also cause QT prolongation, a heart-rhythm change that can lead to life-threatening arrhythmias (torsades de pointes). Ketoconazole is a strong CYP3A4 inhibitor, so combining it with many other drugs — certain statins, some benzodiazepines, ergot alkaloids, dofetilide, quinidine, and cisapride, among others — is contraindicated. Alcohol should be avoided.
Topical ketoconazole (creams, shampoos, foam, gel) is much safer, with side effects that are mainly local, such as skin irritation, itching, or burning. This is not medical advice. Tell your provider about all medicines you take and about any liver problems, and follow their instructions and your medication label.
This Ketoconazole information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Ketoconazole on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Ketoconazole — Articles & Guides
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.