Metaxalone
Metaxalone
What is Metaxalone?
Metaxalone (Skelaxin) is a prescription muscle relaxant used to relieve pain and discomfort caused by muscle strains, sprains, and other musculoskeletal conditions. It is typically used alongside rest, physical therapy, and other treatments to help reduce muscle spasms and improve mobility.
Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Skin rash, severe itching or hives
Warnings
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, or a blood disorder (including anemia).
- This medicine may cause serotonin syndrome, which may be life-threatening when used with certain other medicines or if taken for a long time.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Prescription savings · · · ·
What is Metaxalone ?
Metaxalone (Skelaxin) is a prescription muscle relaxant used to relieve pain and discomfort caused by muscle strains, sprains, and other musculoskeletal conditions. It is typically used alongside rest, physical therapy, and other treatments to help reduce muscle spasms and improve mobility.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Skin rash, severe itching or hives
- Swelling of the face, eyelids, mouth, or lips
- Unusual bruising or bleeding
- Unexplained fever or sore throat
- Yellowing of the skin or eyes
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, or a blood disorder (including anemia).
- This medicine may cause serotonin syndrome, which may be life-threatening when used with certain other medicines or if taken for a long time.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Yellowing of the skin or eyes
Metaxalone Coupons & Prices
Metaxalone
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Looking for a metaxalone coupon? Metaxalone is the generic form of the discontinued brand Skelaxin, a prescription muscle relaxant used to ease discomfort from strains, sprains, and other muscle injuries. Because it is available as a low-cost generic, the cash price is often modest, but it can still vary widely from one pharmacy to the next. Rx.com compares metaxalone prices across more than 60,000 pharmacies so you can find the lowest price near you. Enter your ZIP above to see today's price and print or text your free coupon.
What is metaxalone and how does it work?
Metaxalone is a centrally acting skeletal muscle relaxant. It is FDA-approved as an add-on to rest, physical therapy, and other measures for the relief of discomfort linked to acute, painful musculoskeletal conditions such as strains, sprains, and muscle injuries. It is used in adults and adolescents 13 years and older. Metaxalone was formerly sold under the brand name Skelaxin, which has been discontinued, so today the medication is dispensed as a generic.
Metaxalone does not act directly on the muscle itself. Its benefit is thought to come from its central (sedative) properties, which help relax muscle-related discomfort while your body heals.
Metaxalone cost and savings without insurance
Metaxalone is available as a generic, which usually keeps the cash price lower than a brand-name equivalent would be. Even so, generic prices are not the same everywhere. The amount you pay out of pocket can differ substantially between two pharmacies in the same town, which is exactly why comparing prices matters.
Rx.com checks metaxalone prices across more than 60,000 pharmacies and shows you a free coupon you can use with or without insurance. Enter your ZIP above to see today's price at pharmacies near you. There is no manufacturer savings card for metaxalone, so a discount coupon on the cash price is typically the best route for people paying out of pocket.
Metaxalone alternatives and related muscle relaxants
Metaxalone is one of several muscle relaxants prescribed for short-term relief of muscle discomfort. Your provider chooses among them based on your symptoms, other medications, and how each one affects you. Common alternatives include:
These medications differ in how sedating they are and how they are dosed. This is not medical advice; talk with your provider or pharmacist about which option fits your situation, and compare prices here before you fill.
Metaxalone safety and side effects
Metaxalone has no boxed warning, but it can cause drowsiness and dizziness. Avoid driving or operating machinery until you know how it affects you, and be aware that it can increase the effects of alcohol and other central nervous system depressants. It should not be used by people with known drug-induced hemolytic or other anemias, with significantly impaired kidney or liver function, or with a known hypersensitivity to the product. It should be used with great care in anyone with pre-existing liver damage, and periodic liver function tests may be recommended.
Serotonin syndrome has occurred when metaxalone is combined with other serotonergic medicines such as SSRIs, SNRIs, MAOIs, and triptans, so tell your provider about everything you take. Rare but serious reactions can include hypersensitivity rash, jaundice, low white blood cell counts, and hemolytic anemia. This information is not a substitute for medical advice; always review your full medication list and any concerns with your provider or pharmacist.
This Metaxalone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Metaxalone on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.