Natesto
Natesto 7.32GM of 5.5MG/ACT
What is Natesto?
Natesto is a testosterone nasal gel prescribed for the treatment of conditions associated with a deficiency or absence of endogenous testosterone, such as hypogonadism in men. Administered via a nasal applicator, Natesto offers a convenient, non-injectable delivery method, potentially reducing the risk of transference to others. It is typically applied three times daily, providing a steady hormonal level throughout the day.Side Effects
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, trouble urinating
Warnings
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause the following problems:Increased risk of prostate cancerBlood clot in your leg or lungPossible increased risk of heart attack or strokeLower sperm count
- This medicine is not indicated for use in women and should never be used by a pregnant woman.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Prescription savings · · · ·
What is Natesto ?
Natesto is a testosterone nasal gel prescribed for the treatment of conditions associated with a deficiency or absence of endogenous testosterone, such as hypogonadism in men. Administered via a nasal applicator, Natesto offers a convenient, non-injectable delivery method, potentially reducing the risk of transference to others. It is typically applied three times daily, providing a steady hormonal level throughout the day.- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, trouble urinating
- Chest pain that may spread, trouble breathing, coughing up blood, unusual sweating, faintness
- Pain, redness, or swelling in your arm or leg
- Swelling in your hands, ankles, legs, or feet
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause the following problems:Increased risk of prostate cancerBlood clot in your leg or lungPossible increased risk of heart attack or strokeLower sperm count
- This medicine is not indicated for use in women and should never be used by a pregnant woman.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you have kidney disease, liver disease, diabetes, an enlarged prostate, heart disease, high cholesterol, lung disease, sleep apnea, or a history of heart attack or stroke. Also tell your doctor if you have any nose or sinus problems, including allergies or history of nose or sinus surgery or a broken nose.
Natesto Coupons & Prices
Natesto 7.32GM of 5.5MG/ACT
If you're comparing a Natesto coupon against the manufacturer's own savings program, here's the short version: Natesto (testosterone nasal gel) is the only FDA-approved intranasal testosterone replacement therapy, it's a Schedule III controlled substance with no generic equivalent yet, and enter your ZIP above to see today's price at pharmacies near you before you decide which savings route fits your situation.
What is Natesto and how does it work?
Natesto is a brand-name testosterone nasal gel, FDA-approved as testosterone replacement therapy in adult men with primary hypogonadism or hypogonadotropic hypogonadism (congenital or acquired) — conditions where the body doesn't produce enough of its own testosterone. It's the only intranasal testosterone product on the market, dosed as two pump actuations (one per nostril) three times daily. Natesto is not approved for age-related "low T" without a diagnosed underlying condition, and it is not for use in women or children.
Because it's applied inside the nose rather than rubbed on the skin like a topical gel, Natesto carries no risk of transferring testosterone to a partner or child through skin contact — a consideration that matters for some patients choosing between testosterone formulations.
Natesto coupon vs. the manufacturer savings card
Natesto's manufacturer offers its own savings program through the official Natesto website (natesto.com); terms, eligibility, and whether it applies to your prescription can vary, and manufacturer cards like this are generally restricted to patients with commercial insurance — they typically can't be used if you're uninsured, on Medicare, or on Medicaid. Rx.com's cash coupon works differently: it's not tied to insurance status at all, so it's an option if you don't have coverage, if you're on a government plan that excludes manufacturer copay cards, or if your pharmacy simply can't process the manufacturer's card that day.
Because Natesto has no FDA-approved generic version currently available, there isn't a lower-cost generic alternative to switch to for savings — pricing comparisons here come down to pharmacy, insurance coverage (if any), and which savings program you use. Enter your ZIP above to compare pharmacy prices near you.
Natesto vs. other testosterone replacement options
Natesto is one of several testosterone replacement therapy formulations available by prescription. Topical testosterone gels such as AndroGel are applied to the skin daily and, unlike Natesto, carry a real (if generally low) risk of transferring testosterone to others through skin contact until the application site dries. Injectable options like testosterone cypionate are dosed less frequently (typically every one to two weeks) but require an injection rather than a gel. Your provider can help you weigh dosing frequency, application method, and cost when choosing between these forms of testosterone replacement.
Natesto safety information
Natesto is contraindicated in men with known or suspected prostate or breast cancer, and it must not be used by women, especially during pregnancy or nursing, due to the risk of virilization (masculinizing effects) to a developing fetus. Like other testosterone products, Natesto's label carries FDA-required warnings about potential cardiovascular risk, potential for abuse or dependence, worsening of untreated obstructive sleep apnea, increased red blood cell counts (polycythemia), fluid retention (edema), and changes to the prostate or PSA levels that should be monitored by your provider. Natesto does not currently carry a boxed warning.
Nasal-specific side effects can include nasopharyngitis (cold-like symptoms), runny nose, nosebleeds, and nasal discomfort or scabbing. Natesto is a Schedule III controlled substance, meaning it has an accepted medical use but also a potential for abuse or dependence, and it's dispensed under those additional pharmacy controls. This is general information, not medical advice — talk with your provider about whether Natesto is right for you.
This Natesto information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Natesto on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.