Xyosted Coupons & Prices

If you are looking for a Xyosted coupon, you are in the right place. Xyosted (testosterone enanthate) is a brand-name, once-weekly subcutaneous auto-injector used for testosterone replacement therapy in adult men with hypogonadism, and it is a Schedule III controlled medicine, so it always requires a prescription. There is no generic version of the Xyosted auto-injector, which is a big reason the cash price can be hard to swallow. The free Rx.com discount coupon on this page can be used at the pharmacy counter whether you have insurance or not. Enter your ZIP code above to see today's price at pharmacies near you, then show the coupon to your pharmacist before they ring up your prescription.

What is Xyosted and how does it work?

Xyosted is testosterone enanthate in sesame oil, packaged in a single-dose auto-injector that you give under the skin (subcutaneously) in the abdomen once a week. It comes in 50 mg, 75 mg, and 100 mg strengths per 0.5 mL. Because it is an androgen (a testosterone ester), it replaces the testosterone the body is not making on its own and is classified as a C-III controlled substance.

The FDA has approved Xyosted for testosterone replacement therapy in adult males with primary hypogonadism (congenital or acquired testicular failure) or hypogonadotropic hypogonadism (congenital or acquired gonadotropin or LHRH deficiency). Its safety and effectiveness have not been established for age-related low testosterone (the "low T" of aging) or in males under 18 years old. Only your prescriber can decide whether Xyosted is appropriate for you.

Xyosted cost: manufacturer savings card vs. the Rx.com cash coupon

Search results for a Xyosted coupon are mostly split between the manufacturer's own savings offer and pharmacy discount cards. Here is the honest difference:

• Manufacturer savings card. Xyosted's maker runs an official savings and support program (marketed under the SteadyCare name) on the brand's own website. Like most brand copay cards, it is generally limited to people with commercial insurance. If you are uninsured, or you are covered by Medicare, Medicaid, TRICARE, or another government plan, you are usually not eligible. Eligibility rules, dollar limits, and expiration terms vary and change, so check the manufacturer's official site directly. The program's materials also describe support services and assistance options for eligible patients, so it is worth a call if cost is a barrier.
• Rx.com cash coupon. Our coupon is a cash-price discount, not insurance. It works when you have no insurance at all, when you are on Medicare, or when a copay card is declined at the register. You can also compare the coupon price against your insurance copay and simply use whichever is lower on that day.

Prices for Xyosted swing widely between pharmacies in the same town, so it pays to compare before you fill. Enter your ZIP code above to see today's price at pharmacies near you. One note: you cannot combine a manufacturer copay card and a discount coupon on the same fill, so pick the better of the two.

No generic yet, but other testosterone options are worth asking about

There is currently no FDA-approved generic of the Xyosted auto-injector, so the auto-injector itself has no substitute at the counter. The active ingredient, however, is a long-standing one, and several other testosterone products are widely available. What they cost varies by pharmacy and by your coverage, so it is worth comparing prices rather than assuming any one form is cheaper. Ask your prescriber whether one of these would be reasonable for you:

• Testosterone cypionate and the brand Depo-Testosterone are intramuscular oil injections drawn from a vial with a needle and syringe. The Depo-Testosterone label describes dosing for hypogonadal men as 50 mg to 400 mg every two to four weeks, and in practice prescribers often use a shorter interval, so plan on roughly every 1 to 4 weeks depending on what your prescriber orders.
• Testosterone enanthate vials contain the same ester as Xyosted, but they are a different product and a different injection technique, and are not an automatic substitute for the auto-injector.
• AndroGel is a daily topical gel. It avoids needles, but it carries a boxed warning about secondary exposure of women and children through skin contact.
• Jatenzo is an oral testosterone undecanoate capsule taken twice daily with food, and Natesto is a nasal gel used three times a day.

The trade-offs are convenience, how steady your levels stay, and price. Your prescriber can tell you which form fits your diagnosis and your routine, and you can compare the cash price of each at pharmacies near you.

Safety: what to know before and during treatment

As of the March 2025 label revision, Xyosted no longer carries a boxed warning. The earlier boxed warning about blood pressure increases was removed, and blood pressure is now handled as a Warning and Precaution. It still matters: Xyosted can raise blood pressure, which can increase the risk of major cardiovascular events. It is not recommended for men with uncontrolled high blood pressure, and your blood pressure should be checked and treated if it rises. Other risks on the label include a higher red-blood-cell count (polycythemia). For that reason, the Xyosted label directs your prescriber to confirm your hematocrit is not elevated before you start, and then to evaluate hematocrit approximately every 3 months while you are on treatment; if it becomes elevated, Xyosted is stopped until the level comes down, and it is stopped permanently if the problem returns after restarting. The label also covers blood clots including deep vein thrombosis and pulmonary embolism, worsening of an enlarged prostate and possible increased prostate cancer risk (PSA is monitored), depression and reports of suicidal thoughts and suicide attempts in trials, sleep apnea, swelling, effects on the liver, reduced sperm counts and fertility, and breast enlargement.

Xyosted must not be used during pregnancy (it can harm a developing baby) or by men with breast cancer or known or suspected prostate cancer, or by anyone with a known hypersensitivity to testosterone enanthate or sesame oil. Testosterone is also misused at high, supraphysiologic doses, which has caused serious heart and psychiatric problems, and it can lead to dependence. The most common side effects are increased hematocrit, increased PSA, higher blood pressure, injection-site reactions such as bruising, bleeding, or redness, and headache. This page is information, not medical advice. Talk with your doctor or pharmacist about your own situation, and get medical help right away for chest pain, trouble breathing, leg swelling or pain, or thoughts of harming yourself.