Nitrofurantoin Monohyd Macro
Nitrofurantoin Monohyd Macro 100MG
What is Nitrofurantoin Monohyd Macro?
Nitrofurantoin Monohydrate/Macrocrystals (Macrobid) is a prescription antibiotic used to treat uncomplicated urinary tract infections (UTIs) caused by susceptible bacteria. Its dual formulation provides sustained antibacterial activity to help relieve symptoms such as painful urination, frequent urination, and urinary urgency.
Side Effects
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Yellowing of your skin or the whites of your eyes.
Warnings
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, heart disease, lung disease, anemia, diabetes, a mineral imbalance in the blood, or vitamin B deficiency. Make sure your doctor knows if you have a condition called G6PD-deficiency.
- This medicine may cause your urine to be a brown color. This is normal and will not affect how the medicine works.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- Use this medicine only to treat the infection you now have. This medicine will not work for colds, flu, or other virus infections.
- Diarrhea or loose, watery stools that may contain blood.
Prescription savings · · · ·
What is Nitrofurantoin Monohyd Macro ?
Nitrofurantoin Monohydrate/Macrocrystals (Macrobid) is a prescription antibiotic used to treat uncomplicated urinary tract infections (UTIs) caused by susceptible bacteria. Its dual formulation provides sustained antibacterial activity to help relieve symptoms such as painful urination, frequent urination, and urinary urgency.
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Yellowing of your skin or the whites of your eyes.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blisters, peeling, or red skin rash.
- Cough, fever, chills, weakness, shortness of breath, or chest pain.
- Dark-colored urine or pale stools.
- Diarrhea or loose, watery stools that may contain blood.
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, heart disease, lung disease, anemia, diabetes, a mineral imbalance in the blood, or vitamin B deficiency. Make sure your doctor knows if you have a condition called G6PD-deficiency.
- This medicine may cause your urine to be a brown color. This is normal and will not affect how the medicine works.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- Use this medicine only to treat the infection you now have. This medicine will not work for colds, flu, or other virus infections.
- Diarrhea or loose, watery stools that may contain blood.
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Yellowing of your skin or the whites of your eyes.
Nitrofurantoin Monohyd Macro Coupons & Prices
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Looking for a nitrofurantoin monohydrate/macrocrystals coupon? Nitrofurantoin (the generic form of Macrobid) is a low-cost generic antibiotic used to treat uncomplicated urinary tract infections, but the cash price still varies widely from one pharmacy to the next. Enter your ZIP above to see today's price at pharmacies near you. Rx.com compares prices across more than 60,000 pharmacies so you can find the lowest cash price on your prescription, no insurance required.
What is nitrofurantoin monohydrate/macrocrystals and how does it work?
Nitrofurantoin monohydrate/macrocrystals is a nitrofuran antibiotic (a urinary anti-infective) sold under the brand name Macrobid. It is FDA-approved to treat acute uncomplicated urinary tract infections (acute cystitis, a bladder infection) caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus. This formulation is typically taken twice daily for 7 days and is a recommended first-line option for uncomplicated bladder infections.
The drug concentrates in the urine, where it works to stop the bacteria causing the infection. Because it does not reach adequate levels in the blood or tissues, nitrofurantoin is not effective for kidney infections (pyelonephritis), perinephric abscesses, or other complicated or upper-tract infections. It is sometimes used off-label at a low dose for long-term prevention of recurrent UTIs; your provider can tell you whether that applies to you.
Nitrofurantoin cost and savings without insurance
Nitrofurantoin is available as a generic (generic_available = yes), which usually keeps the cash price low compared with the brand-name Macrobid. Even so, cash prices for the same generic can differ a lot from pharmacy to pharmacy, which is exactly why comparing matters. You do not need insurance to use an Rx.com coupon.
Enter your ZIP above to see today's price at pharmacies near you and pick the lowest one. Rx.com compares cash prices across more than 60,000 pharmacies, so a few minutes of comparison can make a real difference on what you pay out of pocket.
Alternatives and related UTI medications
Nitrofurantoin is one of several first-line options for uncomplicated urinary tract infections. Depending on your situation, your provider may consider other antibiotics, such as:
Nitrofurantoin is the generic equivalent of Macrobid; you can also view the general nitrofurantoin page. The right antibiotic depends on the type of infection and local bacterial resistance, so this is a decision for you and your prescriber, not a substitution to make on your own.
Safety and important warnings
This information is educational and is not medical advice; talk with your doctor or pharmacist about your specific situation. Nitrofurantoin has no FDA boxed warning, but it is not right for everyone. It should not be used in people with significant kidney impairment (reduced kidney function lowers how well it works and raises the risk of side effects), in pregnancy at term (38 to 42 weeks), during labor and delivery or when labor is imminent, in infants under 1 month old, or in anyone who previously had liver problems (cholestatic jaundice) from nitrofurantoin.
Serious but uncommon risks include lung reactions (which can range from short-term to long-term, including pulmonary fibrosis, and rarely can be fatal, especially with long-term use), liver injury, peripheral neuropathy (nerve damage, with higher risk in people with kidney impairment, anemia, diabetes, or certain nutritional deficiencies), and hemolytic anemia in people with G6PD deficiency. Nitrofurantoin can also cause Clostridioides difficile-associated diarrhea. Take it with food to improve absorption and reduce stomach upset. A harmless dark yellow or brown color of the urine is expected. Contact your provider right away about a new cough, trouble breathing, numbness or tingling, or yellowing of the skin or eyes.
This Nitrofurantoin Monohyd Macro information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Nitrofurantoin Monohyd Macro on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.