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Rabeprazole Sodium

Rabeprazole Sodium

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What is Rabeprazole Sodium?

Aciphex is used to treat certain stomach and esophagus conditions. The generic version of Aciphex is Rabeprazole. On average Aciphex is priced at about $658 for a supply of 30, 20 mg delayed-release tablets. Luckily, you can use our Rx.com savings offer to receive an Aciphex discount of up to 80% off the retail price at participating pharmacies near you.

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What is Rabeprazole Sodium ?

Aciphex is used to treat certain stomach and esophagus conditions. The generic version of Aciphex is Rabeprazole. On average Aciphex is priced at about $658 for a supply of 30, 20 mg delayed-release tablets. Luckily, you can use our Rx.com savings offer to receive an Aciphex discount of up to 80% off the retail price at participating pharmacies near you.

  • Fever, swelling in the body, unusual weight gain, change in how much or how often you urinate, blood in the urine
  • Dry mouth, increased thirst, confusion, numbness and tingling around the mouth, fingertips, or feet
  • Seizures, dizziness, fast or uneven heartbeat, muscle cramps or twitching
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Unusual bleeding, bruising, tiredness, or weakness
  • Joint pain, rash on your cheeks or arms that gets worse in the sun
  • Severe diarrhea that does not go away, stomach cramps or pain, nausea, vomiting, loss of appetite, weight loss
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, osteoporosis, blood clotting problems, or vitamin B12 deficiency.
  • This medicine may cause the following problems:Kidney problems, including acute tubulointerstitial nephritisIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS)LupusFundic gland polyps (abnormal growth in the upper part of your stomach)
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
What is rabeprazole sodium used for?

Rabeprazole sodium is a proton pump inhibitor that lowers stomach acid. It is FDA-approved to heal and maintain erosive GERD, to treat symptomatic (non-erosive) GERD, to heal duodenal ulcers, to help eradicate H. pylori infection when combined with amoxicillin and clarithromycin, and to manage long-term hypersecretory conditions such as Zollinger-Ellison syndrome. Aciphex Sprinkle is approved for GERD symptoms in children ages 1 to 11.

Is rabeprazole the same as Aciphex?

Yes. Rabeprazole sodium is the active ingredient in the brand-name medicine Aciphex (and Aciphex Sprinkle). The generic rabeprazole works the same way in the body and is generally less expensive than the brand.

What are the side effects of rabeprazole sodium?

Common effects can include headache and stomach upset. With long-term or high-dose use, PPIs like rabeprazole are associated with a higher risk of bone fractures, low magnesium, vitamin B12 deficiency, and C. difficile-associated diarrhea. Rarer problems include a kidney condition called acute interstitial nephritis, lupus-like reactions, and stomach polyps. Contact your provider about serious or lasting symptoms.

How long does it take for rabeprazole to work?

Some people notice symptom relief within the first day or two, but it can take several days of regular daily use for the full acid-lowering effect. Healing of the esophagus or an ulcer usually takes a course of several weeks. Take it exactly as prescribed and do not stop early just because you feel better.

Is it safe to take rabeprazole long term?

Many people take rabeprazole long term for conditions like erosive GERD or Zollinger-Ellison syndrome, but long-term use carries added risks such as bone fractures, low magnesium, vitamin B12 deficiency, and C. difficile infection. Doctors generally use the lowest effective dose for the shortest needed time. Do not stop suddenly, since acid can rebound. Review long-term use with your provider.

How much does RABEprazole Sodium 20MG cost without insurance?
The price of RABEprazole Sodium 20MG without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of RABEprazole Sodium 20MG?
Common side effects of RABEprazole Sodium 20MG may include: Fever, swelling in the body, unusual weight gain, change in how much or how often you urinate, blood in the urine, Dry mouth, increased thirst, confusion, numbness and tingling around the mouth, fingertips, or feet, Seizures, dizziness, fast or uneven heartbeat, muscle cramps or twitching, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of RABEprazole Sodium 20MG?
Generic versions may be available for RABEprazole Sodium 20MG. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search RABEprazole Sodium 20MG on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for RABEprazole Sodium 20MG?
The cheapest pharmacy for RABEprazole Sodium 20MG depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for RABEprazole Sodium 20MG near you.

Rabeprazole Sodium Coupons & Prices

Rabeprazole Sodium

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Rabeprazole Sodium Tablet — prescription drug image
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Looking for a rabeprazole sodium coupon? Rabeprazole sodium is the low-cost generic version of Aciphex, a proton pump inhibitor (PPI) that lowers stomach acid to treat GERD, ulcers, and related conditions. Because the generic is widely available, cash prices can be very affordable, but they vary a lot from one pharmacy to the next, so comparing matters. Enter your ZIP above to see today's price at pharmacies near you. Rx.com compares prices across more than 60,000 U.S. pharmacies so you can find the lowest cash price without insurance.

What is rabeprazole sodium and how does it work?

Rabeprazole sodium is a proton pump inhibitor (PPI). It works by blocking the pumps in the stomach lining that produce acid, which lowers the overall amount of acid in the stomach. Less acid gives irritated tissue in the esophagus, stomach, and duodenum a chance to heal and eases symptoms like heartburn.

It is FDA-approved to heal and maintain erosive or ulcerative gastroesophageal reflux disease (GERD), to treat symptomatic (non-erosive) GERD, to heal duodenal ulcers, to help eradicate H. pylori infection when combined with amoxicillin and clarithromycin, and for long-term treatment of hypersecretory conditions such as Zollinger-Ellison syndrome. Regular tablets are used in adolescents 12 and older, while Aciphex Sprinkle is approved for GERD symptoms in children ages 1 to 11.

How much does rabeprazole sodium cost without insurance?

Rabeprazole is available as a generic, so it is generally one of the more affordable proton pump inhibitors when you pay cash. The catch is that the price for the exact same prescription can differ widely between pharmacies, even within the same town, which is why comparing before you fill is worth it. Enter your ZIP above to see today's price near you and use the Rx.com coupon at the pharmacy counter.

The brand-name maker of Aciphex also runs an official copay savings program on its website (aciphex.com); those programs typically apply only to the brand product and usually require commercial insurance, and the terms vary and can change. For most people filling the generic, comparing cash prices across pharmacies is the simplest way to keep the cost down.

Rabeprazole vs. other PPIs and alternatives

Rabeprazole is the generic form of Aciphex. It belongs to the same proton pump inhibitor family as several other common acid-reducing medicines, and your prescriber may choose one over another based on your condition, your response, and cost.

Related proton pump inhibitors include:

Each is available at different prices depending on the pharmacy. Do not switch between medicines on your own; talk with your provider or pharmacist first.

Safety and side effects

Rabeprazole has no boxed warning, but like other PPIs it does carry risks, especially with long-term or high-dose use. These include a higher chance of bone fractures (hip, wrist, and spine), low magnesium levels, vitamin B12 deficiency, and Clostridioides difficile-associated diarrhea. Less commonly it has been linked to acute interstitial nephritis (a kidney problem), lupus-like skin and body reactions, and fundic gland polyps in the stomach. Because it can ease symptoms of a more serious stomach condition, it may mask signs of gastric cancer, so new or ongoing warning symptoms should be checked by a doctor.

Rabeprazole can interact with other medicines, including ones whose absorption depends on stomach acid (such as atazanavir and nelfinavir) and with methotrexate, warfarin, and digoxin. It should not be used with rilpivirine-containing products or by anyone allergic to PPIs. Stopping suddenly after long use can cause a temporary rebound in acid. This is general information, not medical advice. Tell your provider about all the medicines you take, and talk with them before starting or stopping rabeprazole.

Sources & accuracy

This Rabeprazole Sodium information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Rabeprazole Sodium on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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