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Restasis Multidose Bottle — prescription drug image

Restasis Multidose

cycloSPORINE (PF) 60 Emulsion

What is Restasis Multidose?

Restasis is used to treat chronic dry eye. There is not a generic version currently available. The average Restasis cash price is expensive at about $586 for 60 plas cont of emulsion. However, you can save on the high Restasis retail cost by using our free Rx.com savings card at a participating pharmacy near you for a discount of up to 80%.

Prescription savings · · · ·

What is Restasis Multidose ?

Restasis is used to treat chronic dry eye. There is not a generic version currently available. The average Restasis cash price is expensive at about $586 for 60 plas cont of emulsion. However, you can save on the high Restasis retail cost by using our free Rx.com savings card at a participating pharmacy near you for a discount of up to 80%.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Feeling like something is in your eye
  • Mild, brief burning in your eyes
  • Red, watery, or itchy eyes
  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have an eye infection.
Is there a generic for Restasis?
Yes. An FDA-approved generic cyclosporine ophthalmic emulsion 0.05% is now available and marketed in the US, and it's usually the best way to lower your cost for this medication.
How long does it take Restasis to work?
Restasis is meant for chronic daily use, and many people don't notice increased tear production right away. It can take weeks to months of consistent twice-daily use before you notice a meaningful improvement in dry eye symptoms.
Can I wear contacts with Restasis?
You should remove contact lenses before applying Restasis and wait at least 15 minutes before putting them back in, since the drops shouldn't be applied while lenses are in place.
What is the difference between Restasis and Xiidra?
Both treat chronic dry eye from inflammation, but they work through different mechanisms - Restasis is a cyclosporine-based immunomodulator, while Xiidra (lifitegrast) blocks a different inflammatory pathway. Your eye doctor can help decide which is a better fit.
Does Restasis sting when you use it?
A temporary burning sensation after applying the drops is the most commonly reported side effect. If burning is severe or doesn't improve, tell your eye doctor.
How much does Restasis Multidose cost without insurance?
The price of Restasis Multidose without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Restasis Multidose?
Common side effects of Restasis Multidose may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Feeling like something is in your eye, Mild, brief burning in your eyes, Red, watery, or itchy eyes. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Restasis Multidose?
Generic versions may be available for Restasis Multidose. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Restasis Multidose on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Restasis Multidose?
The cheapest pharmacy for Restasis Multidose depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Restasis Multidose near you.

Restasis Multidose Coupons & Prices

cycloSPORINE (PF) 60 Emulsion

Restasis Multidose Bottle — prescription drug image
Prescription
Restasis Multidose 5.5ml of 0.05% (1)
your area ·

Restasis Multidose prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
5.5ml of 0.05% · Bottle 5 $541.40 $495.34

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Restasis (cyclosporine ophthalmic emulsion 0.05%) is a twice-daily prescription eye drop for chronic dry eye caused by inflammation. A generic cyclosporine ophthalmic emulsion is now approved and marketed, which is typically the biggest way to lower your cost. Whether you're filling brand Restasis or the generic, enter your ZIP above to see today's price - a Restasis coupon from Rx.com lets you compare pharmacy prices before you check out.

What is Restasis and how does it work?

Restasis contains cyclosporine, an immunomodulator that reduces the inflammation on the eye's surface believed to suppress natural tear production in chronic dry eye. It's dosed as one drop in each affected eye twice a day, about 12 hours apart, and it's meant for ongoing daily use rather than as-needed relief the way artificial tears are.

Restasis is FDA-approved to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca (chronic dry eye disease).

Manufacturer savings card vs. an Rx.com cash coupon, and the generic option

An FDA-approved generic cyclosporine ophthalmic emulsion 0.05% is now marketed and is generally the most effective way to lower your out-of-pocket cost for this exact formulation, so ask your pharmacist whether it's in stock and whether your prescriber will allow a generic substitution.

If you're filling brand-name Restasis, AbbVie offers a savings program for eligible commercially insured patients; terms and eligibility vary and are set by AbbVie, so confirm current details through your provider or AbbVie's official Restasis site. That card typically doesn't apply to Medicare or Medicaid patients. If you're uninsured, on Medicare, or the manufacturer card doesn't apply, an Rx.com coupon lets you compare cash prices for either the brand or the generic across pharmacies near you.

Alternatives to Restasis

Other prescription options for chronic dry eye include Xiidra (lifitegrast), which works through a different anti-inflammatory pathway, and Cequa (cyclosporine 0.09% in a nanomicellar formula), a higher-concentration cyclosporine product. Over-the-counter artificial tears are often used alongside any of these prescription drops. Your eye doctor can help decide which fits your symptoms and history best.

Safety information

The most common side effect of Restasis is a temporary burning sensation in the eye after application; other reported effects include eye redness, discharge, watery eyes, discomfort, and blurred vision. Hypersensitivity reactions have been reported, including eye swelling, hives, and in rare cases more serious swelling of the face, tongue, or throat with difficulty breathing.

Restasis should not be applied while wearing contact lenses; remove lenses before each dose and wait at least 15 minutes before reinserting them. Take care not to let the vial tip touch your eye or any other surface, to avoid injury or contamination. Safety and effectiveness haven't been established in children under 16. This is general information, not medical advice - talk with your eye doctor about whether Restasis is right for you.

Sources & accuracy

This Restasis Multidose information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Restasis Multidose on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.