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Timolol Hemihydrate Bottle — prescription drug image

Timolol Hemihydrate

Timolol Hemihydrate

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What is Timolol Hemihydrate?

Timolol Hemihydrate is a non-selective beta-adrenergic receptor blocking agent commonly used in ophthalmic solutions to reduce intraocular pressure in conditions such as glaucoma and ocular hypertension. By decreasing the production of aqueous humor in the eye, it effectively helps in lowering the risk of optic nerve damage and vision loss associated with elevated eye pressure. Its formulation ensures optimal absorption and efficacy while minimizing potential systemic cardiovascular effects.

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What is Timolol Hemihydrate ?

Timolol Hemihydrate is a non-selective beta-adrenergic receptor blocking agent commonly used in ophthalmic solutions to reduce intraocular pressure in conditions such as glaucoma and ocular hypertension. By decreasing the production of aqueous humor in the eye, it effectively helps in lowering the risk of optic nerve damage and vision loss associated with elevated eye pressure. Its formulation ensures optimal absorption and efficacy while minimizing potential systemic cardiovascular effects.

  • Blurred vision
  • Dizziness
  • Fatigue
  • Nausea
  • Dry eyes
  • Headache
  • Slow heart rate
  • Do not use if you have asthma or severe chronic obstructive pulmonary disease (COPD)
  • Consult your doctor if you have a history of heart failure
  • Use with caution in patients with diabetes
  • Can mask symptoms of low blood sugar
  • Should not be stopped suddenly without consulting a healthcare provider
  • Not recommended during pregnancy unless essential
  • Inform your doctor of any other medications you are taking as interactions can occur
What is timolol hemihydrate eye drops used for?

Timolol hemihydrate ophthalmic solution is FDA-approved to lower elevated pressure inside the eye in people with ocular hypertension or open-angle glaucoma. It is a non-selective beta-blocker eye drop. The usual starting dose is one drop of the 0.25% solution in the affected eye or eyes twice daily, increased to 0.5% twice daily if needed; once pressure is controlled, once-daily dosing is often enough. It is not FDA-approved to treat angle-closure glaucoma on its own. Your eye doctor decides the right strength and schedule for you.

What is the difference between timolol hemihydrate and timolol maleate?

Both deliver the same active medicine, timolol, to the eye, and both are used for the same conditions. The difference is the salt form. Timolol maleate is the older, more widely stocked form and is sold as Timoptic and Istalol. Timolol hemihydrate is the form in Betimol, and it is sometimes preferred for ocular comfort and tolerability. Because they are different products, they are not automatically swapped at the pharmacy counter, so ask your prescriber or pharmacist before switching between them.

What are the side effects of timolol hemihydrate eye drops?

The most common are a brief burning or stinging as the drop goes in, dry eyes, itching, a feeling that something is in the eye, and blurred vision. Because the medicine is absorbed into the bloodstream, it can also cause headache, dizziness, a slow heart rate, low blood pressure, fatigue, and depression. Serious breathing problems and heart failure have been reported, mainly in people who should not be using a beta-blocker in the first place. Get medical help right away for trouble breathing, wheezing, chest symptoms, fainting, or a very slow pulse. This is not a complete list; ask your pharmacist.

Who should not use timolol eye drops?

The label says timolol drops should not be used by people with bronchial asthma or a history of bronchial asthma, severe COPD, sinus bradycardia, second- or third-degree AV block, overt cardiac failure, cardiogenic shock, or an allergy to any ingredient. Extra caution is advised in diabetes, because the drops can mask signs of low blood sugar; in hyperthyroidism, because they can mask signs of thyroid overactivity and abrupt withdrawal may trigger thyroid storm; and in myasthenia gravis or poor blood flow to the brain. Tell your eye doctor your full heart and lung history, and mention the drops before elective surgery.

How much do timolol hemihydrate eye drops cost without insurance?

There is no single cash price. Timolol hemihydrate is available as a generic, but what a pharmacy charges for the same bottle can vary a lot from one location to another, so the only reliable way to know is to check prices near you. Enter your ZIP code above to see today's price at pharmacies in your area and print or show the free Rx.com coupon at the counter. Rx.com compares prices at more than 60,000 pharmacies. If you have insurance, ask the pharmacist to compare your copay against the coupon price and use whichever is lower; the two cannot be combined. The brand Betimol's maker, Thea Pharma, also lists a patient savings card on its official site, with eligibility and terms that vary and usually exclude government insurance.

How much does Timolol Hemihydrate 5ML of 0.5% cost without insurance?
The price of Timolol Hemihydrate 5ML of 0.5% without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Timolol Hemihydrate 5ML of 0.5%?
Common side effects of Timolol Hemihydrate 5ML of 0.5% may include: Blurred vision, Dizziness, Fatigue, Nausea, Dry eyes. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Timolol Hemihydrate 5ML of 0.5%?
Generic versions may be available for Timolol Hemihydrate 5ML of 0.5%. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Timolol Hemihydrate 5ML of 0.5% on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Timolol Hemihydrate 5ML of 0.5%?
The cheapest pharmacy for Timolol Hemihydrate 5ML of 0.5% depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Timolol Hemihydrate 5ML of 0.5% near you.

Timolol Hemihydrate Coupons & Prices

Timolol Hemihydrate

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Timolol Hemihydrate Bottle — prescription drug image
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Timolol Hemihydrate prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
5ml of 0.5% · Bottle 5 $195.99 $63.37
10ml of 0.5% · Bottle 5 $175.49 $63.37
15ml of 0.5% · Bottle 15 $490.99 $163.11

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Use a free Rx.com timolol hemihydrate coupon to compare cash prices on timolol hemihydrate ophthalmic solution (0.25% and 0.5%), the generic eye drop also sold under the brand name Betimol for elevated eye pressure in ocular hypertension and open-angle glaucoma. Cash prices for the same bottle can differ a lot from one pharmacy to the next, which is why comparing is worth the minute it takes. Rx.com checks prices at more than 60,000 pharmacies, so enter your ZIP code above to see today's price near you and bring the coupon to the counter.

What is timolol hemihydrate and how does it work?

Timolol hemihydrate is a non-selective beta-adrenergic blocker (an ophthalmic beta-blocker) given as an eye drop to lower pressure inside the eye. It is FDA-approved to treat elevated intraocular pressure in people with ocular hypertension or open-angle glaucoma. Lowering that pressure is what protects the optic nerve over time, which is why these drops are usually taken every day even though nothing feels different.

The usual starting dose on the label is one drop of the 0.25% solution in the affected eye or eyes twice daily, increased to 0.5% twice daily if the response is not enough. Once eye pressure is controlled, once-daily dosing is often sufficient. Timolol hemihydrate is the active ingredient in Betimol and is therapeutically equivalent in indication to timolol maleate products such as Timoptic and Istalol. It is not FDA-approved as a stand-alone treatment for angle-closure glaucoma. Your eye doctor decides which drop and strength fit your situation.

Timolol hemihydrate cost without insurance and how to save

Timolol hemihydrate ophthalmic solution is available as a generic, and an FDA-approved generic is what most pharmacies will fill unless your prescription says otherwise. What surprises people is how much the cash price for the very same bottle can swing between two pharmacies in the same town, sometimes even between two locations of the same chain. That is the whole reason a coupon comparison matters: the number on the shelf is not one national price.

If you are paying cash, enter your ZIP above to see today's price at pharmacies near you, then show the free Rx.com coupon at the pharmacy counter. There is no membership and no signup. The brand Betimol is made by Thea Pharma, which offers a patient savings card through its own official site; eligibility and terms vary and typically exclude people with government insurance, so read the current terms before counting on it. If you have insurance or Medicare, it is always worth asking the pharmacist to run both your plan and the coupon price and take whichever is lower, since coupon prices cannot be combined with insurance.

Timolol hemihydrate vs. timolol maleate and other glaucoma drops

The most common question is the difference between the two salts. Both deliver the same active beta-blocker, timolol, to the eye. Timolol maleate is the older and more widely stocked salt (sold as Timoptic and Istalol), while the hemihydrate salt is what is in Betimol and is sometimes preferred for ocular comfort and tolerability. They are equivalent in what they are used for, but they are not automatically interchangeable at the pharmacy counter, so ask your prescriber before switching.

Other prescription drops your eye doctor may consider for eye pressure work through different mechanisms and have different side-effect profiles:

  • Latanoprost — a prostaglandin analog, usually dosed once daily
  • Brimonidine tartrate — an alpha agonist
  • Betaxolol — a beta-blocker eye drop that is cardioselective rather than non-selective
  • Dorzolamide-timolol — a combination drop that includes timolol

Prices for these vary widely too, so it is reasonable to compare a few if your doctor says more than one option would work for you.

Timolol hemihydrate safety, side effects, and who should avoid it

Timolol hemihydrate has no FDA boxed warning, but its label carries a prominent cardiac and respiratory warning that deserves plain language: beta-blockers applied to the eye are absorbed into the bloodstream, and the same reactions seen with beta-blockers taken by mouth can happen. That includes severe respiratory reactions and death from bronchospasm in people with asthma, and rarely death from cardiac failure. Because of this, the drops are contraindicated in bronchial asthma or a history of it, severe COPD, sinus bradycardia, second- or third-degree AV block, overt cardiac failure, cardiogenic shock, and in anyone allergic to a component. Tell your eye doctor about your lung and heart history before starting, and use caution with diabetes (the drops can mask signs of low blood sugar), hyperthyroidism (they can mask signs of thyrotoxicosis, and stopping abruptly can trigger thyroid storm), myasthenia gravis, and poor circulation to the brain. Do not stop on your own, and mention the drops before any elective surgery.

The most common effects are transient burning or stinging when the drop goes in, dry eyes, itching, a foreign-body feeling, and blurred vision, along with headache, dizziness, slow heart rate, low blood pressure, fatigue, and depression. One practical tip comes straight from the label: the solution contains benzalkonium chloride, which soft contact lenses absorb, so take lenses out before instilling and wait 5 minutes to put them back in. Separately, many eye doctors and pharmacists teach a technique of gently closing the eye or pressing the inner corner after a drop to limit how much medicine is absorbed into the rest of the body; that is general clinical advice rather than something this product's label states, so ask your own eye doctor whether and how to do it. This page is general information, not medical advice. Talk with your eye doctor or pharmacist about your own care.

Sources & accuracy

This Timolol Hemihydrate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Timolol Hemihydrate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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