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Triple Antibiotic Plus

Triple Antibiotic Plus 28.4GM of 1%

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What is Triple Antibiotic Plus?

Triple Antibiotic Plus is an ointment that combines three antibiotics and a pain reliever. It is used to help prevent infections in minor cuts, scrapes, and burns while also providing relief from pain.

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What is Triple Antibiotic Plus ?

Triple Antibiotic Plus is an ointment that combines three antibiotics and a pain reliever. It is used to help prevent infections in minor cuts, scrapes, and burns while also providing relief from pain.

Source: MedlinePlus, U.S. National Library of Medicine

  • Signs of wound or skin infection: increasing pain, redness, swelling, or drainage of fluid or pus that is cloudy, brown, green, or foul-smelling.
  • New or worsening skin rash.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • New or worsening redness, burning, itching, or swelling in the area where the medicine is applied.
  • Unexplained fever.
  • Some antibacterial skin medicines may cause discoloring of the skin, hair, nails, or may stain clothing.
  • Make sure any doctor who treats you knows that you are using this medicine. Some antibacterial skin medicines may cause problems with certain medical tests.
  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have a tuberculosis infection of the skin. Make sure your doctor knows if you have had an allergic reaction to any antibiotic or topical medicine, such as hydrocortisone, iodochlorhydroxyquin, bacitracin, neomycin, or polymyxin B.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Unexplained fever.
What is the difference between Triple Antibiotic and Triple Antibiotic Plus?
Plain triple antibiotic ointment contains just the three antibacterial ingredients (bacitracin zinc, neomycin sulfate, and polymyxin B sulfate) to help prevent infection. Triple Antibiotic Plus adds pramoxine HCl, a topical anesthetic, so it also provides temporary relief of pain, itching, and discomfort from the wound.
Is Triple Antibiotic Plus the same as Neosporin Plus Pain Relief?
Triple Antibiotic Plus Pain Relief is the generic, store-brand equivalent of the branded product Neosporin + Pain, Itch, Scar. Both contain the same three antibiotics plus pramoxine HCl for pain relief.
How long can you use triple antibiotic ointment on a wound?
The label advises against using it for longer than one week, or over large areas of the body, without checking with a doctor first. If a minor wound isn't healing or seems to be getting worse, stop use and see a doctor.
Can you use triple antibiotic plus pain relief on a burn?
It's labeled for minor burns as part of its first-aid use. It is not intended for serious burns — those should be evaluated and treated by a doctor.
Why do some people get a rash from neomycin-containing ointments?
Neomycin, one of the three antibiotics in this ointment, is a well-recognized contact allergen. With repeated use, some people develop contact dermatitis (a rash, redness, or irritation) as an allergic reaction to it. If a rash or allergic reaction develops, stop use and consult a doctor.
How much does Triple Antibiotic Plus cost without insurance?
The price of Triple Antibiotic Plus without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Triple Antibiotic Plus?
Common side effects of Triple Antibiotic Plus may include: Signs of wound or skin infection: increasing pain, redness, swelling, or drainage of fluid or pus that is cloudy, brown, green, or foul-smelling., New or worsening skin rash., Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, New or worsening redness, burning, itching, or swelling in the area where the medicine is applied., Unexplained fever.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Triple Antibiotic Plus?
Generic versions may be available for Triple Antibiotic Plus. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Triple Antibiotic Plus on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Triple Antibiotic Plus?
The cheapest pharmacy for Triple Antibiotic Plus depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Triple Antibiotic Plus near you.

Triple Antibiotic Plus Coupons & Prices

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Triple Antibiotic Plus Pain Relief is an over-the-counter first-aid ointment that combines three topical antibiotics (bacitracin zinc, neomycin sulfate, and polymyxin B sulfate) with the local anesthetic pramoxine HCl to help prevent infection in minor cuts, scrapes, and burns while easing the pain and itching that come with them; you don't need a prescription to buy it, but it's still worth using a Rx.com triple-antibiotic-plus coupon or checking your ZIP above, since store-brand and branded versions of the same formula can be priced differently from pharmacy to pharmacy.

What Triple Antibiotic Plus Is and How It Works

Triple Antibiotic Plus Pain Relief ointment is the generic equivalent of Neosporin + Pain, Itch, Scar, and it's also sold under store brands such as Signature Care, Good Sense, and Family Care, along with CVS and Walgreens versions labeled "Triple Antibiotic Plus Pain Relief." It follows an FDA OTC monograph: bacitracin zinc, neomycin sulfate, and polymyxin B sulfate work together to help prevent bacterial infection on the skin's surface, while pramoxine HCl is added purely for temporary relief of the pain, itching, and discomfort that come with minor wounds.

This product is intended for minor cuts, scrapes, and burns only. It is not meant for deep or puncture wounds, animal bites, serious burns, or for use in or near the eyes — those situations call for a doctor's evaluation instead.

Saving on Triple Antibiotic Plus

Because Triple Antibiotic Plus is a generic, OTC first-aid product, there's no manufacturer copay card involved — it isn't a prescription drug with brand-name pricing to offset. Instead, prices for the branded Neosporin + Pain, Itch, Scar version and the various store-brand equivalents can vary noticeably by retailer, so it's worth comparing before you buy. Enter your ZIP above to see today's price at pharmacies near you, and a Rx.com coupon may still lower what you pay out of pocket versus the shelf price, even on an OTC item.

Comparing Triple Antibiotic Plus to Other Options

If you don't need the added pain relief, plain Neosporin or its generic equivalent, bacitracin ointment alone, cover the same basic first-aid antibiotic need without pramoxine. Polysporin is a neomycin-free alternative (bacitracin plus polymyxin B only), which some people choose specifically because neomycin is a common cause of allergic skin reactions. For infections or wounds a doctor wants treated with a prescription-strength option, mupirocin and silver sulfadiazine (used for certain burns) are prescription topical antibiotics your provider may recommend instead.

The right choice depends on the wound and whether you want pain relief built in — ask a pharmacist if you're unsure which is appropriate.

Safety Information

Triple Antibiotic Plus is for external use only and should not be used in or near the eyes. Don't use it for longer than one week or over large areas of the body without asking a doctor first, and avoid it on deep or puncture wounds, animal bites, or serious burns unless a doctor has told you to. Stop using it and check with a doctor if you develop a rash, signs of an allergic reaction, or if symptoms get worse or don't improve.

Neomycin, one of the three antibiotics in this product, is a well-known cause of contact allergy, and contact dermatitis is the most common side effect with repeated use. Keep this product out of reach of children, and call Poison Control at 1-800-222-1222 if it's swallowed. This information isn't a substitute for medical advice — talk to your doctor or pharmacist about your specific wound or skin condition.

Sources & accuracy

This Triple Antibiotic Plus information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Triple Antibiotic Plus on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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