Triple Antibiotic Plus
Triple Antibiotic Plus 28.4GM of 1%
What is Triple Antibiotic Plus?
Triple Antibiotic Plus is an ointment that combines three antibiotics and a pain reliever. It is used to help prevent infections in minor cuts, scrapes, and burns while also providing relief from pain.Side Effects
- Signs of wound or skin infection: increasing pain, redness, swelling, or drainage of fluid or pus that is cloudy, brown, green, or foul-smelling.
- New or worsening skin rash.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Some antibacterial skin medicines may cause discoloring of the skin, hair, nails, or may stain clothing.
- Make sure any doctor who treats you knows that you are using this medicine. Some antibacterial skin medicines may cause problems with certain medical tests.
- Make sure your doctor knows if you are pregnant or breast feeding, or if you have a tuberculosis infection of the skin. Make sure your doctor knows if you have had an allergic reaction to any antibiotic or topical medicine, such as hydrocortisone, iodochlorhydroxyquin, bacitracin, neomycin, or polymyxin B.
- Call your doctor if your symptoms do not improve or if they get worse.
- Unexplained fever.
Prescription savings · · · ·
What is Triple Antibiotic Plus ?
Triple Antibiotic Plus is an ointment that combines three antibiotics and a pain reliever. It is used to help prevent infections in minor cuts, scrapes, and burns while also providing relief from pain.- Signs of wound or skin infection: increasing pain, redness, swelling, or drainage of fluid or pus that is cloudy, brown, green, or foul-smelling.
- New or worsening skin rash.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- New or worsening redness, burning, itching, or swelling in the area where the medicine is applied.
- Unexplained fever.
- Some antibacterial skin medicines may cause discoloring of the skin, hair, nails, or may stain clothing.
- Make sure any doctor who treats you knows that you are using this medicine. Some antibacterial skin medicines may cause problems with certain medical tests.
- Make sure your doctor knows if you are pregnant or breast feeding, or if you have a tuberculosis infection of the skin. Make sure your doctor knows if you have had an allergic reaction to any antibiotic or topical medicine, such as hydrocortisone, iodochlorhydroxyquin, bacitracin, neomycin, or polymyxin B.
- Call your doctor if your symptoms do not improve or if they get worse.
- Unexplained fever.
Triple Antibiotic Plus Coupons & Prices
Triple Antibiotic Plus 28.4GM of 1%
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Triple Antibiotic Plus Pain Relief is an over-the-counter first-aid ointment that combines three topical antibiotics (bacitracin zinc, neomycin sulfate, and polymyxin B sulfate) with the local anesthetic pramoxine HCl to help prevent infection in minor cuts, scrapes, and burns while easing the pain and itching that come with them; you don't need a prescription to buy it, but it's still worth using a Rx.com triple-antibiotic-plus coupon or checking your ZIP above, since store-brand and branded versions of the same formula can be priced differently from pharmacy to pharmacy.
What Triple Antibiotic Plus Is and How It Works
Triple Antibiotic Plus Pain Relief ointment is the generic equivalent of Neosporin + Pain, Itch, Scar, and it's also sold under store brands such as Signature Care, Good Sense, and Family Care, along with CVS and Walgreens versions labeled "Triple Antibiotic Plus Pain Relief." It follows an FDA OTC monograph: bacitracin zinc, neomycin sulfate, and polymyxin B sulfate work together to help prevent bacterial infection on the skin's surface, while pramoxine HCl is added purely for temporary relief of the pain, itching, and discomfort that come with minor wounds.
This product is intended for minor cuts, scrapes, and burns only. It is not meant for deep or puncture wounds, animal bites, serious burns, or for use in or near the eyes — those situations call for a doctor's evaluation instead.
Saving on Triple Antibiotic Plus
Because Triple Antibiotic Plus is a generic, OTC first-aid product, there's no manufacturer copay card involved — it isn't a prescription drug with brand-name pricing to offset. Instead, prices for the branded Neosporin + Pain, Itch, Scar version and the various store-brand equivalents can vary noticeably by retailer, so it's worth comparing before you buy. Enter your ZIP above to see today's price at pharmacies near you, and a Rx.com coupon may still lower what you pay out of pocket versus the shelf price, even on an OTC item.
Comparing Triple Antibiotic Plus to Other Options
If you don't need the added pain relief, plain Neosporin or its generic equivalent, bacitracin ointment alone, cover the same basic first-aid antibiotic need without pramoxine. Polysporin is a neomycin-free alternative (bacitracin plus polymyxin B only), which some people choose specifically because neomycin is a common cause of allergic skin reactions. For infections or wounds a doctor wants treated with a prescription-strength option, mupirocin and silver sulfadiazine (used for certain burns) are prescription topical antibiotics your provider may recommend instead.
The right choice depends on the wound and whether you want pain relief built in — ask a pharmacist if you're unsure which is appropriate.
Safety Information
Triple Antibiotic Plus is for external use only and should not be used in or near the eyes. Don't use it for longer than one week or over large areas of the body without asking a doctor first, and avoid it on deep or puncture wounds, animal bites, or serious burns unless a doctor has told you to. Stop using it and check with a doctor if you develop a rash, signs of an allergic reaction, or if symptoms get worse or don't improve.
Neomycin, one of the three antibiotics in this product, is a well-known cause of contact allergy, and contact dermatitis is the most common side effect with repeated use. Keep this product out of reach of children, and call Poison Control at 1-800-222-1222 if it's swallowed. This information isn't a substitute for medical advice — talk to your doctor or pharmacist about your specific wound or skin condition.
This Triple Antibiotic Plus information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Triple Antibiotic Plus on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.