Unisom Sleeptabs
Unisom SleepTabs 48 Tablets
What is Unisom Sleeptabs?
Unisom SleepTabs are an over-the-counter sleep-aid containing the antihistamine doxylamine succinate as the active ingredient. They are used to treat short-term sleep disturbances by blocking histamine receptors, thereby promoting drowsiness and facilitating sleep. Unisom SleepTabs are non-habit-forming when used as directed and are typically taken 30 minutes before bedtime to help achieve a restful night's sleep.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Call your doctor if your symptoms do not improve or if they get worse.
- This medicine may make you dizzy or drowsy. Use the tablet only at bedtime. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Make sure your doctor knows if you or your child are pregnant or breastfeeding, or if you have glaucoma, breathing problems (such as emphysema or bronchitis), or problems with urination due to an enlarged prostate.
- If sleeplessness lasts longer than 2 weeks, talk to your doctor.
- You should not give the tablet to a child under 12 years of age.
Prescription savings · · · ·
What is Unisom Sleeptabs ?
Unisom SleepTabs are an over-the-counter sleep-aid containing the antihistamine doxylamine succinate as the active ingredient. They are used to treat short-term sleep disturbances by blocking histamine receptors, thereby promoting drowsiness and facilitating sleep. Unisom SleepTabs are non-habit-forming when used as directed and are typically taken 30 minutes before bedtime to help achieve a restful night's sleep.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Call your doctor if your symptoms do not improve or if they get worse.
- This medicine may make you dizzy or drowsy. Use the tablet only at bedtime. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Make sure your doctor knows if you or your child are pregnant or breastfeeding, or if you have glaucoma, breathing problems (such as emphysema or bronchitis), or problems with urination due to an enlarged prostate.
- If sleeplessness lasts longer than 2 weeks, talk to your doctor.
- You should not give the tablet to a child under 12 years of age.
- Children receiving the suspension form of this medicine tend to get more excited. Talk to your doctor if this concerns you.
Unisom Sleeptabs Coupons & Prices
Unisom SleepTabs 48 Tablets
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Unisom Sleeptabs prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 32 tablets · Bottle | 48 | $25.48 | $20.75 |
| 48 tablets · Bottle | 48 | $16.99 | $16.97 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Unisom SleepTabs (doxylamine succinate) is an over-the-counter, first-generation antihistamine used as a nighttime sleep aid for occasional sleeplessness, and a generic version of doxylamine succinate is also available; enter your ZIP above to see today's price and pull up an Rx.com coupon before you check out, since even OTC products can vary in price by pharmacy.
What Is Unisom SleepTabs and How Does It Work?
Unisom SleepTabs contain doxylamine succinate, a sedating (first-generation) antihistamine in the ethanolamine class. It's labeled for temporary relief of occasional sleeplessness in adults and children 12 and older, working by reducing the time it takes to fall asleep. Doxylamine is also used off-label, often paired with pyridoxine (vitamin B6), for nausea and vomiting of pregnancy; that specific combination is the basis of the prescription drug Diclegis.
Save on Unisom SleepTabs with an Rx.com Coupon
Unisom SleepTabs is sold over the counter, and a generic doxylamine succinate version is also available. Prices for both brand and generic OTC sleep aids vary by pharmacy and location, so it's worth comparing before you buy. Enter your ZIP code above to check today's price at pharmacies near you and see whether an Rx.com coupon brings the cost down further.
Unisom SleepTabs vs. Alternatives
Unisom also sells a gel-capsule version, Unisom SleepGels, which uses a different active ingredient (diphenhydramine, the same antihistamine found in Benadryl/diphenhydramine) rather than doxylamine. Some people also compare sedating antihistamines to melatonin, a hormone-based sleep aid with a different mechanism. Since these products differ in active ingredient and side-effect profile, talk to a pharmacist or your provider about which fits your situation.
Safety Information
Unisom SleepTabs is not labeled for children under 12, and it shouldn't be combined with other products containing diphenhydramine, doxylamine, or other sleep aids. The label advises avoiding alcohol and using caution with asthma, COPD, glaucoma, or difficulty urinating due to an enlarged prostate; it can cause marked drowsiness, so avoid driving or operating machinery until you know how it affects you. Anticholinergic side effects like dry mouth, dizziness, and constipation are possible, and elderly patients in particular should use it with caution due to fall risk. This product isn't intended for long-term use — stop and see a doctor if sleeplessness lasts more than two weeks. This is general information, not medical advice; talk with your doctor or pharmacist about whether it's right for you.
This Unisom Sleeptabs information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Unisom Sleeptabs on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
