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Uretron D/S Tablet — prescription drug image

Uretron D/S

Uretron D/S 81.6MG

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What is Uretron D/S?

Uretron D/S is a combination pharmaceutical used primarily to treat symptoms of urinary tract infections and to provide relief from pain, urgency, and discomfort. It contains multiple active ingredients including methenamine, which inhibits bacterial growth, and sodium phosphate, which acidifies the urine, making it less hospitable to bacteria. This medication is typically prescribed in cases where increased urinary antiseptic action is required.

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What is Uretron D/S ?

Uretron D/S is a combination pharmaceutical used primarily to treat symptoms of urinary tract infections and to provide relief from pain, urgency, and discomfort. It contains multiple active ingredients including methenamine, which inhibits bacterial growth, and sodium phosphate, which acidifies the urine, making it less hospitable to bacteria. This medication is typically prescribed in cases where increased urinary antiseptic action is required.
  • Dizziness
  • Nausea
  • Blurred vision
  • Dry mouth
  • Headache
  • Fatigue
  • Constipation
  • Avoid driving or operating heavy machinery until you know how Uretron D/S affects you.
  • Consult your doctor if you have a history of kidney or liver disease before starting Uretron D/S.
  • May cause increased sensitivity to sunlight. Use sunscreen and wear protective clothing when outdoors.
  • Contact your physician immediately if you experience severe side effects such as difficulty breathing or severe abdominal pain.
What is Uretron D/S used for?
It's used to relieve symptoms of irritative voiding and local urinary tract symptoms—inflammation, spasm, and pain—that accompany lower urinary tract infections, as well as urinary symptoms caused by diagnostic procedures. It treats symptoms; it is not a substitute for an antibiotic when you have a confirmed bacterial infection.
Does Uretron D/S turn urine blue?
Yes. The methylene blue ingredient commonly turns urine a blue-green color. This is a harmless, expected effect, but let your doctor or pharmacist know if it happens so it isn't mistaken for something else.
Is Uretron D/S an antibiotic?
Not in the way most antibiotics work. It contains methenamine, a mild urinary antiseptic that works best in acidic urine, but Uretron D/S is a symptom-relief and adjunct product, not a primary treatment for a confirmed bacterial UTI. Your provider may still prescribe a separate antibiotic for the infection itself.
What are the side effects of Uretron D/S?
Because of its anticholinergic ingredient, it can cause typical anticholinergic effects and should be used cautiously in people with glaucoma, myasthenia gravis, certain GI or urinary obstructions, or some heart rhythm conditions. It also turns urine blue-green (from methylene blue) and can raise the risk of serotonin syndrome if combined with serotonergic drugs like SSRIs, SNRIs, or MAOIs. Ask your pharmacist or doctor about your specific health history before starting it.
Can you take Uretron D/S with an antibiotic for a UTI?
Often yes, since Uretron D/S is meant to relieve symptoms alongside treatment rather than replace an antibiotic—but it should not be combined with sulfa-based antibiotics like trimethoprim-sulfamethoxazole without your provider's guidance, since methenamine can interact with sulfonamides. Confirm any combination with your prescriber or pharmacist first.
How much does Uretron D/S cost without insurance?
The price of Uretron D/S without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 26% off retail prices with a free Rx.com coupon.
What are the common side effects of Uretron D/S?
Common side effects of Uretron D/S may include: Dizziness, Nausea, Blurred vision, Dry mouth, Headache. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Uretron D/S?
Generic versions may be available for Uretron D/S. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Uretron D/S on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Uretron D/S?
The cheapest pharmacy for Uretron D/S depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Uretron D/S near you.

Uretron D/S Coupons & Prices

Uretron D/S 81.6MG

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Uretron D/S Tablet — prescription drug image
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Uretron D/S 81.6mg (6)
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Uretron D/S prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
81.6mg · Tablet 30 $81.95 $60.75

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a Uretron D/S coupon? This urinary tract combination product (methenamine, sodium phosphate monobasic, phenyl salicylate, methylene blue, and hyoscyamine sulfate) is available as a generic, but cash prices for combination generics like this one can still vary a lot from one pharmacy to the next. Rx.com compares prices across 60,000+ U.S. pharmacies so you can see where it costs less before you fill it—just enter your ZIP above to see today's price near you.

What Is Uretron D/S and How Does It Work?

Uretron D/S is a combination product built around methenamine, a mild urinary antiseptic that works best when urine is acidic, paired with sodium phosphate monobasic (a urinary acidifier), phenyl salicylate (a local urinary tract analgesic), methylene blue (a mild urinary antiseptic that also colors urine), and hyoscyamine sulfate (an anticholinergic that relaxes bladder muscle spasm).

It's labeled for symptoms of irritative voiding and for relief of local urinary tract symptoms—inflammation, spasm/hypermotility, and pain—that go along with lower urinary tract infections, as well as urinary symptoms caused by diagnostic procedures. It is important to understand what it is not: Uretron D/S is a symptomatic, adjunct product, not a primary antibiotic. It does not replace a systemic antibiotic when you have a confirmed bacterial UTI.

Uretron D/S Cost and Coupon Savings

A generic version of Uretron D/S is available, but that doesn't mean the price is the same everywhere. Cash prices on combination generics like this one can swing widely between pharmacies in the same town, so comparing before you fill is worth the extra minute. Enter your ZIP code above to see today's price at pharmacies near you and find the lowest one for this fill.

There is no manufacturer savings card for this product. If you're weighing options, ask your pharmacist whether a similar-acting generic combination is stocked locally, since availability of this specific combination can vary by pharmacy.

Uretron D/S Alternatives and Related Drugs

Depending on what your provider is treating, a few related medications may come up in the same conversation:

  • Methenamine is the urinary antiseptic ingredient in Uretron D/S, also available on its own.
  • Hyoscyamine is the anticholinergic ingredient in Uretron D/S, also prescribed alone for bladder spasm and other conditions.
  • Phenazopyridine is a different urinary tract analgesic often used short-term for pain and burning with a UTI (it also discolors urine, orange-red rather than blue-green).
  • Nitrofurantoin and trimethoprim-sulfamethoxazole are systemic antibiotics actually used to treat a confirmed bacterial UTI—ask your provider whether you need one of these in addition to symptom relief.

Note: because Uretron D/S contains methenamine, it should not be combined with sulfa-containing antibiotics like trimethoprim-sulfamethoxazole without your provider's guidance, since the combination can cause a precipitate to form in urine.

Uretron D/S Safety Information

Uretron D/S does not carry an FDA boxed warning. Because of its anticholinergic (hyoscyamine) component, it should be used with caution or avoided in people with glaucoma, myasthenia gravis, obstructive disease of the GI or urinary tract, or certain cardiac conditions such as tachyarrhythmias; in obstructive uropathy it can cause acute urinary retention. The methylene blue component will turn urine blue-green, which is harmless but worth knowing about in advance, and it carries a risk of serotonin syndrome if combined with serotonergic medications such as SSRIs, SNRIs, or MAOIs. It should be avoided in severe kidney or liver impairment, and the labeling advises against use in pregnancy and in infants because of the methylene blue component.

This is general information, not medical advice. Talk with your doctor or pharmacist about whether Uretron D/S is right for you, especially if you take other medications.

Sources & accuracy

This Uretron D/S information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Uretron D/S on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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