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Valproic Acid

Valproic Acid 250MG

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What is Valproic Acid?

Depakene is used to treat certain types of seizure disorders. The generic version of Depakene is valproic acid. On average, a supply of 30, 250 mg Depakene oral capsules cost about $198. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.

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What is Valproic Acid ?

Depakene is used to treat certain types of seizure disorders. The generic version of Depakene is valproic acid. On average, a supply of 30, 250 mg Depakene oral capsules cost about $198. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.
  • Thoughts of hurting yourself, depression, unusual changes in behavior or moods
  • Unusual bleeding, bruising, or weakness
  • Sudden and severe stomach pain, nausea, vomiting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Confusion, problems with memory, unusual drowsiness, clumsiness
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, rash, swollen glands in the neck, armpits, or groin
  • Tiny red dots on the skin, especially on the lower legs
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, blood disease, pancreas problems, or a viral infection (including HIV or cytomegalovirus infection).
  • This medicine can increase the risk for depression and thoughts of suicide. Tell your doctor if you have a history of depression or mental health problems.
  • This medicine may cause the following problems:Liver problemsPancreatitis (swelling of the pancreas)Hyperammonemic encephalopathy (too much ammonia in your blood)Bleeding problems (including thrombocytopenia)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage the organs, including the liver, kidney, or heart
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
What is valproic acid used for?
Valproic acid is FDA-approved to treat complex partial seizures (alone or combined with other seizure medicines), simple and complex absence seizures, and as an add-on treatment for patients who have multiple types of seizures including absence seizures. It's also approved to help prevent migraine headaches. It is sometimes used off-label for bipolar disorder or mood symptoms, but that is not part of its main FDA-approved use.
What are the side effects of valproic acid?
Valproic acid's most serious risks are outlined in its boxed warnings: liver damage (which can be fatal, especially in the first six months of treatment and in young children), pancreatitis, and, if taken during pregnancy, risk of harm to the developing baby. It can also lower platelet counts and raise blood ammonia levels. Because the full list of possible side effects is longer than can be covered here, ask your doctor or pharmacist for the complete safety information, and get medical attention right away for symptoms like yellowing skin/eyes, severe stomach pain, unusual bruising, or confusion.
Is valproic acid the same as Depakote?
No. Depakote is divalproex sodium, a related but different salt formulation of valproate — not the same product as valproic acid, even though both are used to treat seizures. Depakote also has its own separate FDA approval for bipolar disorder. Depakene, the original brand name for valproic acid itself, has largely been discontinued, so valproic acid is now available as a generic.
Can you take valproic acid during pregnancy?
Valproic acid carries a boxed warning for fetal risk. It can cause major congenital malformations, including neural tube defects, at a rate the FDA describes as roughly four times higher than with other anti-seizure medications used alone. Separately, the label also states that valproate exposure in the womb can lower children's IQ scores — this IQ finding is a distinct risk from the malformation data and is not itself quantified as a four-times figure. For this reason valproic acid is generally avoided during pregnancy and in women who could become pregnant unless no other treatment works for them. This decision should always be made with your doctor, weighing your specific seizure or migraine control needs against these risks.
How much does valproic acid cost without insurance?
Valproic acid is sold as a generic, but the cash price still varies by pharmacy, location, and dosage form. Rather than relying on a single quoted price, compare valproic acid pricing at pharmacies near you — enter your ZIP code above on Rx.com to see today's price at pharmacies in your area.
How much does Valproic Acid cost without insurance?
The price of Valproic Acid without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 63% off retail prices with a free Rx.com coupon.
What are the common side effects of Valproic Acid?
Common side effects of Valproic Acid may include: Thoughts of hurting yourself, depression, unusual changes in behavior or moods, Unusual bleeding, bruising, or weakness, Sudden and severe stomach pain, nausea, vomiting, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, or red skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Valproic Acid?
Generic versions may be available for Valproic Acid. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Valproic Acid on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Valproic Acid?
The cheapest pharmacy for Valproic Acid depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Valproic Acid near you.

Valproic Acid Coupons & Prices

Valproic Acid 250MG

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Valproic Acid Bottle — prescription drug image
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Valproic Acid 473ml of 250mg/5ml (0.74)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a valproic acid coupon? Valproic acid is a generic anticonvulsant, so there is no brand markup to shop around — but the price at the counter can still swing widely from one pharmacy to the next. Rx.com compares valproic acid pricing across more than 60,000 U.S. pharmacies so you can see where it costs less near you before you fill; enter your ZIP above to see today's price.

What Is Valproic Acid and How Does It Work?

Valproic acid is a fatty-acid derivative anti-seizure medication (anticonvulsant) that is FDA-approved as monotherapy or adjunctive therapy for complex partial seizures, for simple and complex absence seizures, as adjunctive therapy for patients with multiple seizure types that include absence seizures, and for prevention (prophylaxis) of migraine headaches. It's also sometimes prescribed off-label for bipolar disorder and mood-related conditions, though that is not part of its core FDA label.

A related valproate product, divalproex sodium, carries its own FDA approval for manic episodes of bipolar disorder — see the comparison section below for how it differs from plain valproic acid.

Valproic Acid Cost and How to Save

Valproic acid is available as a generic, and generic pricing already tends to run lower than brand-name drugs. That said, cash prices for the same generic drug can still vary a lot by pharmacy, chain, and location — there's no single "list price" that applies everywhere. The best way to know what you'll actually pay is to compare live prices rather than guess.

  • Enter your ZIP code above to compare valproic acid prices at pharmacies near you
  • Prices can differ significantly even between two pharmacies a few miles apart
  • There is currently no manufacturer savings card for valproic acid, since it's a generic-only medication — check with your pharmacist about other savings options available at the counter

Valproic Acid vs. Depakote and Other Seizure Medications

Valproic acid is not the same product as Depakote. Depakote is divalproex sodium — a related but chemically different salt formulation of valproate — and it's not automatically interchangeable with valproic acid. The original brand-name valproic acid product, Depakene, has largely been discontinued as a brand, and valproic acid capsules and syrup are now sold generically.

If your doctor is considering other anti-seizure options, related medications include divalproex sodium, lamotrigine, levetiracetam, topiramate, and carbamazepine. Never switch between these without your prescriber's guidance — seizure medications are not simple substitutes for one another.

Valproic Acid Safety Information

Valproic acid carries boxed warnings — the FDA's most serious safety alert — for hepatotoxicity (liver damage, including fatal cases, most often within the first six months of treatment, with the highest risk in children under 2), for fetal risk when used during pregnancy (including neural tube defects and other major birth defects), and for pancreatitis, which can occur at any point during treatment and can be fatal. The label also warns about low platelet counts (thrombocytopenia), elevated blood ammonia (hyperammonemia, which can occur even with normal liver tests), and interactions with other medications such as lamotrigine and certain antibiotics. Baseline and periodic blood tests to monitor liver function and platelets are typically required.

This is general information, not medical advice — talk with your doctor or pharmacist about whether valproic acid is right for you and how it should be monitored.

Sources & accuracy

This Valproic Acid information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Valproic Acid on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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