Impact-Site-Verification: 2721d812-1059-4270-b9fa-5c1654788cd1

Xulane Box    — prescription drug image

Xulane

Xulane 3 Patch Weekly

Prescriptions & Refills
Licensed US providers · Online visit in minutes

What is Xulane?

Xulane is a skin patch used as a birth control by women to prevent pregnancy. Ethinyl Estradiol-norelgestromin is the generic version of Xulane. Xulane costs around $142 for a supply of 3, 150 mcg/35 mcg patches, but luckily there are ways to save money. You can use our Rx.com Xulane savings caXulane is a prescription birth control patch used to help prevent pregnancy in women of reproductive age. The patch delivers a combination of estrogen and progestin hormones through the skin to prevent ovulation and reduce the likelihood of pregnancy. Learn about Xulane uses, effectiveness, dosage, side effects, cost, and contraceptive options available through Rx.com.rd to save significantly on the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Xulane ?

Xulane is a skin patch used as a birth control by women to prevent pregnancy. Ethinyl Estradiol-norelgestromin is the generic version of Xulane. Xulane costs around $142 for a supply of 3, 150 mcg/35 mcg patches, but luckily there are ways to save money. You can use our Rx.com Xulane savings caXulane is a prescription birth control patch used to help prevent pregnancy in women of reproductive age. The patch delivers a combination of estrogen and progestin hormones through the skin to prevent ovulation and reduce the likelihood of pregnancy. Learn about Xulane uses, effectiveness, dosage, side effects, cost, and contraceptive options available through Rx.com.rd to save significantly on the retail price at participating pharmacies near you.

  • Sudden or severe headache, or problems with vision, speech, or walking
  • Sudden and severe stomach pain, nausea, vomiting, lightheadedness
  • Unusual or unexpected vaginal bleeding
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Irregular, late, or missed menstrual period
  • Dark urine or pale stools, loss of appetite, yellow skin or eyes
  • Chest pain or tightness, trouble breathing, coughing up blood
  • Breast lumps, tenderness, pain, swelling, or discharge
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Pain in your lower leg (calf)
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • This medicine will not protect you from getting HIV/AIDS or other sexually transmitted diseases.
  • This medicine may not work as well in women who weigh 198 pounds (90 kilograms) or more.
  • If you think you have become pregnant while using this medicine, tell your doctor right away.
  • Tell your doctor if you are breastfeeding or if you recently had a baby. Tell your doctor if you have kidney disease, epilepsy, diabetes, high cholesterol levels, high blood pressure, gallbladder disease, migraine headaches, irregular monthly periods, or a history of depression, or chloasma gravidarum (skin discoloration during pregnancy). Tell your doctor if you are having a surgery that requires inactivity for a long time or if you smoke.
  • This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsLiver problems (including liver cancers or tumors)High blood pressureGallbladder diseaseHigh cholesterol in the bloodPossible risk of breast or cervical cancer
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. You may need to stop using this medicine for a few weeks before and after surgery because of the risk of blood clots.
  • Unusual or unexpected vaginal bleeding
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
Is Xulane the same as the Ortho Evra patch?
Xulane is the generic equivalent of Ortho Evra and contains the same hormones, norelgestromin and ethinyl estradiol, in a weekly patch. Ortho Evra, the original brand, has been discontinued, so Xulane and other generics such as Onsura and Zafemy are what is available today.
Where on the body do you apply the Xulane patch?
The patch is applied to clean, dry, intact skin. It should be placed on an area where it will not be rubbed by tight clothing, and it should never be applied to the breasts. Follow the specific application instructions in the Xulane patient information and ask your pharmacist or provider if you are unsure.
Does Xulane cause weight gain?
Weight change is reported by some people using hormonal contraceptives, but responses vary from person to person. If you notice weight changes or other side effects that concern you, talk with your doctor rather than stopping the patch on your own.
How effective is the Xulane patch at preventing pregnancy?
When used correctly and consistently, the Xulane patch is a highly effective form of birth control. Effectiveness depends on using it exactly as directed and replacing each patch on schedule. Note that Xulane is contraindicated in women with a BMI of 30 kg/m2 or higher, in whom it may be both less effective and less safe. It does not protect against HIV or other sexually transmitted infections.
Can you use Xulane if you smoke or have a BMI over 30?
Xulane has a boxed warning against use in women over 35 who smoke, because smoking increases the risk of serious cardiovascular events. Xulane is also contraindicated (it should not be used) in women with a BMI of 30 kg/m2 or higher, in whom it may be less effective and carries a higher risk of blood clots. Your provider can help you choose a safer option based on your health.
How much does Xulane cost without insurance?
The price of Xulane without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Xulane?
Common side effects of Xulane may include: Sudden or severe headache, or problems with vision, speech, or walking, Sudden and severe stomach pain, nausea, vomiting, lightheadedness, Unusual or unexpected vaginal bleeding, Numbness or weakness in your arm or leg, or on one side of your body, Irregular, late, or missed menstrual period. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Xulane?
Generic versions may be available for Xulane 3 Patch Weekly. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Xulane 3 Patch Weekly on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Xulane?
The cheapest pharmacy for Xulane 3 Patch Weekly depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Xulane 3 Patch Weekly near you.

Xulane Coupons & Prices

Xulane 3 Patch Weekly

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Xulane Box    — prescription drug image
Prescription
Xulane box (3 patches), 150-35mcg/24hr (1)
your area ·
Prescription weight loss

Weight-loss medication, prescribed online

Licensed U.S. providers · No insurance needed · Shipped to your door

$146/mo vs. brand-name GLP-1 medications $1,300+/mo Save up to 88%
See if I qualify Free online visit · No commitment
Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Xulane coupon? Xulane is the weekly birth-control patch that delivers norelgestromin and ethinyl estradiol through the skin, and it is available as a lower-cost generic. With an Rx.com cash coupon you can compare today's pharmacy prices near you and pay the discounted cash price even if you are uninsured, on Medicare, or your insurance does not cover it. Enter your ZIP above to see today's price at pharmacies in your area.

What is Xulane and how does the patch work?

Xulane is a combined hormonal contraceptive skin patch that contains two hormones, norelgestromin (a progestin) and ethinyl estradiol (an estrogen). Each patch releases about 150 mcg of norelgestromin and 35 mcg of ethinyl estradiol per day to help prevent pregnancy. It is FDA-approved to prevent pregnancy in women of reproductive potential with a body mass index (BMI) under 30 kg/m2 who choose a patch as their method of birth control.

You wear one patch per week for three weeks in a row, then have one patch-free week (when your period usually comes), for a four-week cycle. Xulane is a generic equivalent of the original Ortho Evra patch, which has been discontinued. It is sometimes used off-label to help manage or regulate menstrual cycles, but it is not FDA-approved for those purposes. Xulane does not protect against HIV or other sexually transmitted infections.

Xulane cost: manufacturer savings card vs. Rx.com cash coupon

The maker of Xulane runs an official manufacturer savings program, described on the manufacturer's Xulane website. Manufacturer copay cards like this are generally limited to people with commercial (private) insurance, and the terms, eligibility, and any expiration can change, so check the program's current details before you rely on it. These cards typically cannot be used if you have no insurance or if you are covered by a government program such as Medicare or Medicaid.

An Rx.com cash coupon works differently: it is a cash-price discount you can use whether you are uninsured, covered by Medicare or Medicaid, or simply told the manufacturer card was declined. Because Xulane is itself the generic version of the discontinued Ortho Evra, choosing the generic patch is the single biggest lever for lowering your cost. Prices vary by pharmacy and change over time, so enter your ZIP above to see today's price near you and bring the coupon to the pharmacy counter.

Xulane alternatives and how they compare

Xulane is one of several combined hormonal birth-control options, and the right one depends on your health history and how you prefer to take it. Other patch and non-pill choices include Twirla, another weekly contraceptive patch, and NuvaRing, a monthly vaginal ring. If you prefer a daily pill, common combined oral contraceptives include Sprintec, Junel Fe, and Ortho Tri-Cyclen.

All of these use estrogen plus a progestin, but they differ in the specific hormones, dosing schedule, and how they are used. Your provider can help you weigh effectiveness, side effects, and your personal risk factors. This is general information, not medical advice, so talk with your doctor or pharmacist about which method fits you best.

Xulane safety and important warnings

Xulane carries an FDA boxed warning. Cigarette smoking raises the risk of serious cardiovascular events with combined hormonal contraceptives, and Xulane should not be used by women over 35 who smoke. The boxed warning also states that Xulane is contraindicated in women with a BMI of 30 kg/m2 or higher, who may have a higher risk of venous blood clots. Because the patch can expose users to roughly 60% more total estrogen than a typical 35 mcg estrogen pill, there is added concern for venous thromboembolism (blood clots), stroke, and heart attack.

Xulane is contraindicated in people with a BMI of 30 kg/m2 or higher, in those at high risk of arterial or venous blood clots, and in those with breast or other estrogen-sensitive cancers, liver disease or tumors, undiagnosed abnormal vaginal bleeding, or a known or suspected pregnancy. This is a summary and not a complete list. Tell your doctor about your full medical history, and seek care right away for warning signs such as chest pain, sudden shortness of breath, severe leg pain or swelling, or a sudden severe headache. Always follow your provider's guidance.

Sources & accuracy

This Xulane information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Xulane on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

Sponsored
Sesame Care — 350+ medications for $1 without insurance
¿Buscando esta página en español?

Browse more medications: starting with X · full A-Z directory · by condition · common drugs

Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


Don't Miss Out On Savings!

Rx.com does not warrant the accuracy of the information on this website. All information on this site is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of a drug is safe, appropriate, or effective for you. Consult your healthcare professional before using any drug. All logos, brand names and trademarks on this website are the property of their respective owners. Rx.com is not endorsed or affiliated with any brands represented on this website."

Pharmacy discounts are Not Insurance, and are Not Intended as a Substitute for Insurance THE DISCOUNT IS ONLY AVAILABLE AT PARTICIPATING PHARMACIES As an Amazon Associate, we earn from qualifying purchases.

2026 All Rights Reserved | Rx.com®