How to Get Quad Rx Online: Visit, Prescription and Delivery Explained
Quad Rx blends apomorphine, sildenafil, tadalafil, and vardenafil into a single, pharmacy-compounded option for erectile dysfunction-available entirely through an online visit at Rx.com.
Getting Quad Rx online is a simple three-step process: complete a secure telehealth questionnaire and video chat, let a licensed U.S. provider review whether the four-in-one formula is appropriate for your erectile dysfunction, and, if approved, receive the medication discreetly to your door with free express shipping, starting at $69.99 per month. Because Quad Rx is a patient-specific compounded medication and not FDA-approved as a combination product, it is available only through Rx.com’s pharmacy network after this prescription visit.
- Quad Rx combines apomorphine, sildenafil, tadalafil, and vardenafil-three FDA-approved PDE5 inhibitors plus a dopamine agonist-in one compounded sublingual liquid.
- The entire consult happens online; DEA and HHS telemedicine flexibilities allow ED medicines to be prescribed without an initial in-person exam through December 31 2026. (telehealth.hhs.gov)
- Intro pricing is $99 per month with auto-refills, and shipping is included in every U.S. state where Rx.com operates.
- Quad Rx may help men who did not respond to a single PDE5 pill alone but are medically cleared for combination therapy.
Quad Rx is a pharmacy-compounded ED medication that merges four proven agents
Quad Rx is a compounded prescription that combines apomorphine, sildenafil, tadalafil, and vardenafil in one sublingual liquid prepared for a single patient. Each PDE5 inhibitor is FDA-approved on its own, but the four-drug mixture itself is not, so it must be produced by a 503A compounding pharmacy after a provider writes a patient-specific prescription. FDA allows this practice when a licensed prescriber determines the individual needs a customized preparation. (fda.gov)
Definition: Quad Rx is a patient-specific, non-FDA-approved compounded medication priced from $69.99 per month through Rx.com, designed for men with erectile dysfunction who may benefit from multiple mechanisms in a single dose.
Because Quad Rx is not mass-manufactured, you will not find it on retail shelves or comparison lists; it is dispensed only by the network pharmacy after your Rx.com provider’s approval.
The four ingredients target erection pathways from two angles
Sildenafil, tadalafil, and vardenafil inhibit phosphodiesterase-5 (PDE5), boosting nitric-oxide-mediated blood flow, while apomorphine activates dopamine receptors in the brain’s erection center. By addressing both central and peripheral pathways, the combination may help men who found a single-mechanism pill ineffective.
Apomorphine onset: Studies show a median erection time of about 19 minutes for sublingual apomorphine. (pubmed.ncbi.nlm.nih.gov)
Vardenafil onset: An at-home trial recorded successful intercourse as early as 10 minutes post-dose. (pubmed.ncbi.nlm.nih.gov)
Sildenafil onset: A classic pharmacokinetic study found most men achieved usable rigidity within 30–60 minutes, with effects lasting up to 4 hours. (pmc.ncbi.nlm.nih.gov)
Tadalafil duration: The drug’s half-life of 17.5 hours can support erectile response for up to 36 hours after dosing. (dailymed.nlm.nih.gov)
| Ingredient | Typical Onset | Action Window | Key Mechanism |
|---|---|---|---|
| Apomorphine | ~20 min | Up to 2 h | Dopamine agonist (central) |
| Sildenafil | 30–60 min | Up to 4 h | PDE5 inhibition |
| Vardenafil | ≈10–25 min | Up to 5 h | PDE5 inhibition |
| Tadalafil | 30–120 min | ≈36 h | PDE5 inhibition, long half-life |
The provider tailors ingredient ratios case-by-case, so exact milligrams differ between patients.
A fully online visit meets current DEA & HHS rules
Your Quad Rx journey starts with a 10-minute intake form covering health history, medications, and ED severity, followed by a brief video or secure messaging visit. Telehealth is considered appropriate for erectile-dysfunction evaluation according to HHS best-practice guides. (telehealth.hhs.gov)
The licensed U.S. provider confirms blood-pressure control, cardiovascular status, and potential drug interactions. If Quad Rx is safe, they send a patient-specific prescription to the compounding pharmacy.
DEA’s current flexibilities let clinicians prescribe Schedule IV ED drugs like sildenafil via telemedicine without a prior in-person exam until at least December 31 2026, provided state law also permits it. (telehealth.hhs.gov)
You’ll receive confidential messages in your Rx.com dashboard if lab work or additional documentation is needed.
Quad Rx starts at $69.99 per month-often less than stacking separate pills
One $99 subscription covers the entire compounded formula, clinician oversight, and shipping. By contrast, buying three separate generics at typical cash prices can cost more.
| Medication | Average cash price (30 doses) | Monthly cost if taken together |
|---|---|---|
| Generic sildenafil 50 mg | $27 | $93 |
| Generic tadalafil 10 mg | $42 | |
| Generic vardenafil 10 mg | $24 | |
| Total separate-pill spend | $93 | |
| Quad Rx (all four) | $99 flat | |
Prices above reflect national average retail figures published in January 2026; you can compare cash prices at local pharmacies on Rx.com with a free discount card.
Delivery is discreet and requires no extra fees
Once compounded, Quad Rx ships free by express delivery (1-5 business days) in a plain, unbranded package with tracking. Cold-chain handling is not required, so you do not need to be home for refrigeration.
Expect first-month delivery within 3–5 business days after prescription approval. Ongoing refills arrive automatically every four weeks unless your provider pauses therapy for safety checks.
Check if Quad Rx is right for you
Quad Rx may be appropriate for men 18–75 with moderate-to-severe ED who have tried but not fully responded to a single PDE5 drug and who have stable cardiovascular status. It is not suited for men taking nitrates, riociguat, or potent CYP3A4 inhibitors, or those with severe hypotension.
Should you try Quad Rx?
Check the column that fits your situation:
✅ Looks like a fit
- You have ED symptoms at least half the time
- Blood pressure is well controlled (<140/90 mm Hg)
- No nitrates or riociguat in your medication list
- Tried sildenafil or tadalafil with partial benefit
- Able to join a brief video or phone visit
🏥 See a doctor first
- Chest pain or angina during sex
- Recent heart attack or stroke (<6 months)
- Uncontrolled hypertension (>170/100 mm Hg)
- Severe kidney or liver impairment
- Use of nitrates (nitroglycerin spray, isosorbide)
- Vision loss related to NAION
💡 Related reading
Learn more about online men’s-health care in our guide How Telehealth Treats Erectile Dysfunction and compare platforms in Best Erectile Dysfunction Telehealth Options. For a head-to-head look at common pills, see Sildenafil vs. Tadalafil.
🚨 When to Contact Your Healthcare Provider
Contact your doctor immediately if you experience any of the following:
- Chest pain during sexual activity - may signal heart strain
- An erection lasting longer than 4 hours - risk of priapism
- Sudden vision loss - could indicate NAION
- Sudden hearing decrease or ringing - rare auditory side effect
- Severe dizziness or fainting - possible blood-pressure drop
- Swelling of lips, tongue, or throat - sign of an allergic reaction
- Shortness of breath at rest - may signal cardiovascular instability
- Uncontrolled headaches - could reflect unsafe blood pressure changes
Scientific References
- Herbenick D, et al. Erectile dysfunction prevalence in the United States: National Survey of Sexual Wellbeing 2021. J Sex Med. 2024.
- National Institute of Diabetes and Digestive and Kidney Diseases. Erectile Dysfunction: Definition & Facts. 2023.
- Boolell M, et al. Onset and duration of action of sildenafil. Br J Clin Pharmacol. 2000.
- Padma-Nathan H, et al. Earliest time to onset of action with vardenafil: randomized trial. Urology. 2006.
- DailyMed. Tadalafil prescribing information. Updated 2024.
- Heaton JP, et al. Sublingual apomorphine for ED. Int J Impot Res. 2001.
- U.S. Food & Drug Administration. Compounding and the FDA: Questions and Answers. Updated 2026.
- HHS Telehealth. Prescribing controlled substances via telehealth. Updated 2026.
Frequently Asked Questions
Is Quad Rx FDA-approved?
No. Quad Rx is a compounded medication made for one patient at a time, so the combination itself does not undergo FDA approval. Each individual ingredient is FDA-approved for other uses.
Do I need lab work before getting Quad Rx?
Most men do not, but your Rx.com provider may request recent blood-pressure or lipid results if you have cardiac risk factors. Labs can be uploaded electronically.
How quickly will Quad Rx start working?
Because it contains fast-acting vardenafil, some users notice an effect in as little as 10 minutes, while full benefit typically appears within an hour.
Can I take alcohol with Quad Rx?
Moderate alcohol is generally safe, but heavy drinking can worsen ED and lower blood pressure excessively. Limit to two standard drinks.
Will insurance cover Quad Rx?
Most insurers do not cover custom compounded ED formulas, so Rx.com offers a flat $99 self-pay price.
Can I still use my discount card for other prescriptions?
Yes. Your Rx.com free discount card works on over 10,000 generics at local pharmacies-use it for unrelated medications.
What if Quad Rx does not work for me?
Message your provider through your dashboard. They may adjust the ingredient ratios or recommend a different ED strategy, such as daily tadalafil or vacuum-device therapy.
