Acetaminophen-Codeine
Acetaminophen-Codeine 300-30MG
What is Acetaminophen-Codeine?
If you suffer from moderate to severe pain, your doctor might prescribe acetaminophen/codeine #3. The medication has been used to treat muscular, post-surgical, and dental pain. Care should be taken when using acetaminophen/codeine #3 as it can be habit forming. Acetaminophen/codeine #3 should only be taken under the supervision of an experienced physician.Side Effects
- Trouble breathing, blue lips or nails
- Extreme drowsiness or confusion
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, adrenal problems (including Addison disease), or breathing problems (including sleep apnea). Tell your doctor if you have an enlarged prostate, trouble urinating, stomach problems, an underactive thyroid, or a history of head injury or brain damage. Tell your doctor if you had an allergic reaction to sulfites or if you have a history of drug or alcohol abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome (when used with certain medicines)Serious skin reactions
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
Prescription savings · · · ·
What is Acetaminophen-Codeine ?
If you suffer from moderate to severe pain, your doctor might prescribe acetaminophen/codeine #3. The medication has been used to treat muscular, post-surgical, and dental pain. Care should be taken when using acetaminophen/codeine #3 as it can be habit forming. Acetaminophen/codeine #3 should only be taken under the supervision of an experienced physician.- Trouble breathing, blue lips or nails
- Extreme drowsiness or confusion
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Lightheadedness, dizziness, or fainting
- Extreme weakness, shallow breathing, slow heartbeat, sweating, seizures, cold or clammy skin
- Unusual bleeding or bruising
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, adrenal problems (including Addison disease), or breathing problems (including sleep apnea). Tell your doctor if you have an enlarged prostate, trouble urinating, stomach problems, an underactive thyroid, or a history of head injury or brain damage. Tell your doctor if you had an allergic reaction to sulfites or if you have a history of drug or alcohol abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome (when used with certain medicines)Serious skin reactions
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Acetaminophen-Codeine Coupons & Prices
Acetaminophen-Codeine 300-30MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Acetaminophen-Codeine prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 300-30mg · Tablet | 20 | $20.99 | $15.83 |
| 300-60mg · Tablet | 20 | $53.99 | $13.58 |
| 300-15mg · Tablet | 20 | $16.39 | $11.74 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for an acetaminophen-codeine coupon? Acetaminophen and codeine phosphate is a prescription combination pain reliever, available as an affordable FDA-approved generic, that pairs codeine (an opioid) with acetaminophen (the active ingredient in Tylenol). Cash prices for the same tablet can vary widely from one pharmacy to the next, so comparing before you fill matters. Enter your ZIP above to see today's price and a free Rx.com discount coupon accepted at more than 60,000 U.S. pharmacies.
What is acetaminophen-codeine and how does it work?
Acetaminophen-codeine is a combination medicine that brings together two different pain relievers. Codeine is an opioid (also called a narcotic) analgesic that acts on the brain and nervous system to change how the body senses pain. Acetaminophen is a non-opioid analgesic and antipyretic, meaning it adds extra pain relief and also lowers fever. Together they are FDA-approved to relieve mild to moderately severe pain in situations where an opioid combined with acetaminophen is appropriate.
The best-known brand was Tylenol with Codeine (the tablets labeled #3 and #4), though that brand has been discontinued in the U.S.; an oral suspension has also been marketed as Capital and Codeine. Because it contains codeine, this medicine is a federally controlled substance (Schedule C-III) and is only available with a prescription.
Cost without insurance and how to save
Because acetaminophen-codeine is available as a generic, it is generally one of the lower-cost prescription pain medicines even if you pay cash. That does not mean every pharmacy charges the same, though. Cash prices for the identical strength and quantity can differ a lot between a big chain, a grocery-store pharmacy, and an independent down the street, which is exactly why it pays to compare before you fill.
Rx.com compares prices across more than 60,000 pharmacies so you can see where your prescription is cheapest near you. There is no manufacturer copay or savings card for this generic, and you do not need insurance to use a discount coupon. Enter your ZIP above to see today's price at pharmacies near you and print, text, or show your free Rx.com coupon at the counter.
Related medicines and alternatives
Acetaminophen-codeine is one of several combination and single-ingredient pain options your prescriber may consider. Other prescription combinations that pair an opioid with acetaminophen include hydrocodone-acetaminophen and oxycodone-acetaminophen. Tramadol is another prescription pain reliever with opioid activity. The individual ingredients are also used on their own: codeine and over-the-counter acetaminophen (sold as Tylenol).
These medicines differ in strength, controlled-substance status, and side effects, so only your prescriber can decide which is right for you. If you have been prescribed acetaminophen-codeine, you can use Rx.com to compare its cash price against these alternatives and find the lowest price near you.
Important safety information
Acetaminophen-codeine carries FDA boxed warnings. Like all opioids, it has a risk of addiction, abuse, and misuse that can lead to overdose and death, and it can cause life-threatening respiratory depression (dangerously slow or shallow breathing), especially when you first start it or after a dose increase. Some people are "ultra-rapid metabolizers" who convert codeine to morphine very quickly; because of the risk of fatal respiratory depression, codeine is contraindicated in children under 12 and for pain after tonsil or adenoid surgery in children under 18, and it can pass through breast milk. Prolonged use during pregnancy can cause neonatal opioid withdrawal syndrome, and combining opioids with benzodiazepines or other central-nervous-system depressants (including alcohol) is dangerous. A REMS (Risk Evaluation and Mitigation Strategy) applies to opioid analgesics.
The acetaminophen component can cause severe liver damage; do not exceed 4,000 mg of acetaminophen per day from all sources, and rare but serious skin reactions (such as SJS/TEN) have been reported. This is a summary, not a complete list of risks. Take it exactly as prescribed and talk with your doctor or pharmacist about your full health history and any other medicines you take.
This Acetaminophen-Codeine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Acetaminophen-Codeine on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.