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Astepro Spray Btl — prescription drug image

Astepro

Astepro 23ML of 205.5MCG/SPRAY

Prescriptions & Refills
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What is Astepro?

Astepro (azelastine hydrochloride) is a prescription nasal antihistamine spray used for the relief of symptoms associated with seasonal and perennial allergic rhinitis, such as nasal congestion, sneezing, and runny nose. It works by blocking histamine receptors and reducing inflammation, providing fast-acting relief that can begin in as little as 15 minutes and last for up to 24 hours.

Prescription savings · · · ·

What is Astepro ?

Astepro (azelastine hydrochloride) is a prescription nasal antihistamine spray used for the relief of symptoms associated with seasonal and perennial allergic rhinitis, such as nasal congestion, sneezing, and runny nose. It works by blocking histamine receptors and reducing inflammation, providing fast-acting relief that can begin in as little as 15 minutes and last for up to 24 hours.
  • Bitter taste in mouth
  • Headache
  • Nosebleeds
  • Throat pain
  • Avoid operating heavy machinery or driving if drowsiness occurs
  • Consult a doctor if nasal problems worsen after use
  • May increase the risk of glaucoma or cataracts with prolonged use
  • Do not use continuously for more than a specific number of days without consulting a healthcare provider
Is Astepro available over the counter?
Yes. Astepro Allergy 0.15% is sold over the counter for adults and children 6 years and older, and it was the first intranasal antihistamine the FDA approved for OTC sale, in 2021. Children's Astepro Allergy is the same strength with pediatric dosing, also for ages 6 and up. Prescription azelastine nasal spray is still available as a generic in two strengths, and their approved uses differ: the generic 0.15% spray is approved for seasonal and perennial allergic rhinitis in patients 6 years and older, while the generic 0.1% spray is approved for seasonal allergic rhinitis in adults and children 5 years and older and for vasomotor rhinitis in adults and adolescents 12 years and older.
Is Astepro the same as azelastine?
Yes. Astepro is a brand name for azelastine hydrochloride nasal spray, and azelastine is the generic name for the same active ingredient. Generic azelastine nasal spray is available by prescription. Which costs you less, the brand or the generic, depends on the pharmacy, so it is worth comparing both with your ZIP code before you buy.
How is Astepro different from Flonase?
They are different types of medicine. Astepro is an antihistamine that blocks histamine in the nose, and it tends to work fast, often within about 15 to 30 minutes. Flonase is fluticasone, an intranasal steroid that reduces inflammation and usually needs several days of regular use to reach its full effect. Antihistamine sprays are often chosen for quick relief, steroid sprays for steady ongoing control.
Can you use Astepro and Flonase together?
Clinicians commonly pair an intranasal antihistamine with an intranasal steroid when one spray alone is not controlling symptoms, and there is a single prescription product, Dymista, that combines azelastine with fluticasone in one bottle. Still, do not start combining products on your own. Ask your clinician or pharmacist whether using both is right for you and how to time the doses.
Does Astepro make you sleepy, and how fast does it work?
It can make you sleepy. Even though it is sprayed into the nose, azelastine can cause drowsiness, so avoid alcoholic drinks and take care driving or using machinery until you know how it affects you; sedatives and tranquilizers may increase the drowsiness. On timing, relief is usually fast, often starting within about 15 to 30 minutes, and the spray is typically used once or twice a day.
How much does Astepro cost without insurance?
The price of Astepro without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 27% off retail prices with a free Rx.com coupon.
What are the common side effects of Astepro?
Common side effects of Astepro may include: Bitter taste in mouth, Headache, Nosebleeds, Throat pain. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Astepro?
Generic versions may be available for Astepro. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Astepro on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Astepro?
The cheapest pharmacy for Astepro depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Astepro near you.

Astepro Coupons & Prices

Astepro 23ML of 205.5MCG/SPRAY

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Astepro Spray Btl — prescription drug image
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Astepro prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
4ml of 205.5mcg/spray · Spray Btl 4 $12.69 $8.00
11ml of 205.5mcg/spray · Spray Btl 11 $15.29 $13.26
23ml of 205.5mcg/spray · Spray Btl 23 $28.72 $20.87
30ml of 205.5mcg/spray · Spray Btl 30 $54.99 $27.54

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Astepro (azelastine hydrochloride nasal spray) is an antihistamine you spray into your nose for runny nose, sneezing, itchy nose, and nasal congestion. Astepro Allergy 0.15% is sold over the counter for adults and children 6 years and older, and prescription azelastine nasal spray is still available as a generic. Because it comes in both an over-the-counter and a prescription form, what you pay can vary a lot from one pharmacy to the next. The free coupon on this page applies when azelastine or Astepro is filled as a prescription at the pharmacy counter. Enter your ZIP code above to see today's price at pharmacies near you before you buy.

What Astepro is and how it works

Astepro is the brand name for azelastine hydrochloride nasal spray, a second-generation intranasal antihistamine (an H1-receptor blocker). Instead of taking a pill, you spray the medicine directly into the nose, where it blocks histamine, the chemical your body releases during an allergic reaction. That is what brings down the runny nose, sneezing, itching, and stuffiness. Relief tends to start quickly, often within about 15 to 30 minutes, and it is usually used once or twice a day.

Astepro Allergy 0.15% was the first intranasal antihistamine the FDA approved for over-the-counter sale (the switch happened in 2021). The OTC product temporarily relieves nasal congestion, runny nose, sneezing, and itchy nose from hay fever or other upper respiratory allergies in adults and children 6 years and older; Children's Astepro Allergy is the same 0.15% strength with pediatric dosing, also for ages 6 and up. Neither OTC product is for children under 6.

Prescription azelastine nasal spray is still on the market as a generic, in two strengths, and the two strengths do not carry the same approved uses. The generic 0.15% spray is approved for seasonal and perennial (year-round) allergic rhinitis in patients 6 years of age and older. The generic 0.1% spray is approved for seasonal allergic rhinitis in adults and children 5 years and older, and for vasomotor rhinitis (a non-allergic runny nose set off by things like weather changes or strong odors) in adults and adolescents 12 years and older; it does not carry a perennial allergic rhinitis indication. If your clinician writes for azelastine, ask which strength you are getting and what it is approved to treat. A related product, Dymista, combines azelastine with the steroid fluticasone in one spray.

How to use it and what to expect

Follow the directions on the package or from your pharmacist. In general, blow your nose gently first, prime the pump if it is new or has not been used in a while, and spray into each nostril while keeping your head tilted slightly forward. Do not sniff hard after spraying. That one habit matters more than people expect, because the most common complaint about azelastine is a bitter or unpleasant taste, and it happens when the spray runs down the back of the throat. The spray is for use in the nose only, not in the eyes or mouth, and you should not share a bottle with anyone else.

Ask a doctor before use if you have had recent nose ulcers or nose surgery, or a nose injury that has not healed. If you are pregnant or breastfeeding, talk with your clinician before starting. This page is general information, not medical advice, so bring any questions about dosing or how long to use it to your pharmacist or provider.

Cost and how to save on Astepro

Astepro Allergy is an over-the-counter product, so most insurance plans will not cover it the way they cover a prescription. It is also worth understanding how a pharmacy discount card actually works: the card is processed as a prescription claim at the pharmacy counter, so it generally cannot be applied to an OTC box you pick off the shelf and carry to the front register. The coupon price on this page applies when azelastine or Astepro is filled as a prescription. Prescription azelastine nasal spray is still available as a generic, and pharmacies price it differently from one another. Enter your ZIP code above to see today's price at pharmacies near you.

A few practical ways to bring the cost down:

  • Ask your clinician whether a prescription for azelastine nasal spray makes sense for you. Filled as a prescription, it can be paired with the coupon on this page; the coupon does not apply to an over-the-counter bottle bought off the shelf.
  • Compare the brand price with the price for generic azelastine nasal spray. Which one costs you less depends on the pharmacy and the strength, so check both rather than assuming.
  • Check more than one pharmacy. Prices for the same spray can differ meaningfully across chains in the same ZIP code.
  • If you are buying the OTC bottle, compare shelf prices at a few stores. Retailers set OTC pricing themselves, and it is not the same everywhere.
  • The manufacturer runs its own savings program on the official Astepro Allergy website. Terms, eligibility, and availability vary and change over time, so read the current terms there before counting on it.

Our coupon is free and requires no insurance, and it can be used for either the brand or the generic when the spray is filled as a prescription at the pharmacy counter.

Astepro compared with other allergy sprays

Astepro is an antihistamine spray. The other big category of nasal allergy spray is the intranasal steroid, which works differently by calming inflammation in the nose. Steroid sprays such as Flonase (fluticasone) and Nasonex (mometasone) take longer to reach full effect, often several days of regular use, while azelastine tends to work within about 15 to 30 minutes. Many people find a steroid spray better for steady, day-in day-out control and an antihistamine spray better for fast relief.

Olopatadine nasal spray is another intranasal antihistamine and is the closest alternative to azelastine. When one spray alone is not enough, clinicians often use an antihistamine spray together with a steroid spray; Dymista is the fixed combination of azelastine and fluticasone in a single bottle. Which approach fits you is a conversation to have with your clinician or pharmacist. Prices vary widely between these options, so it is worth checking each one with your ZIP code above.

Safety and side effects

Astepro has no boxed warning. The side effect that surprises people most is drowsiness. Even though the medicine is sprayed into the nose, azelastine can still make you sleepy. Avoid alcoholic drinks, and be careful driving or operating machinery until you know how it affects you; sedatives and tranquilizers may add to the drowsiness. The other very common complaint is a bitter or unpleasant taste right after spraying, which is usually milder if you keep your head tilted slightly forward and avoid sniffing hard. Nasal discomfort or sneezing can happen right after use.

Other reported side effects include headache, burning or discomfort in the nose, nosebleed, sore throat, dry mouth, dizziness, fatigue, and nausea. Ask a doctor before use if you have had recent nose ulcers or nose surgery, or a nose injury that has not healed. The OTC sprays are not for children under 6 years; the generic prescription 0.1% spray is approved down to age 5 for seasonal allergies, so ask a clinician what is appropriate for a younger child. Discuss use during pregnancy or breastfeeding with your clinician. Stop using it and get medical care for severe or frequent nosebleeds or any sign of an allergic reaction. This is general information and not a substitute for advice from your own provider.

Sources & accuracy

This Astepro information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Astepro on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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