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Bijuva

Bijuva 30 Capsules

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What is Bijuva?

Bijuva is a medication that combines estradiol and progesterone, two hormones that are important for women's health. It is used to treat symptoms associated with menopause, such as hot flashes and vaginal dryness.

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What is Bijuva ?

Bijuva is a medication that combines estradiol and progesterone, two hormones that are important for women's health. It is used to treat symptoms associated with menopause, such as hot flashes and vaginal dryness.

Source: MedlinePlus, U.S. National Library of Medicine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred or other changes in vision
  • Breast lumps or tenderness
  • Chest pain that may spread, coughing up blood, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, diarrhea, muscle pain, dizziness, fainting
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with memory, speech, or walking
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Redness, pain, burning, or itching in or near your vagina
  • Unusual vaginal bleeding, spotting, discharge, or itching
  • Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, high blood pressure, diabetes, high cholesterol, obesity, lupus, migraine headaches, thyroid problems, edema (swelling), endometriosis, hereditary angioedema, asthma, seizures, porphyria, or a history of cancer. Tell your doctor if you have had your uterus (womb) removed (hysterectomy). Tell your doctor if you smoke or if you are having surgery that will require inactivity for a long time.
  • This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsIncreased risk of endometrial, breast, or ovarian cancerPossible risk of dementia (especially in women 65 years of age or older)Gallbladder problemEye or vision problemsHigh blood pressureHigh cholesterol or fats in the bloodThyroid problems
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is Bijuva used for?
Bijuva is FDA-approved to treat moderate-to-severe hot flashes (vasomotor symptoms) caused by menopause in women who still have a uterus. It combines estradiol to relieve symptoms with progesterone to protect the uterine lining. It should be used at the lowest effective dose for the shortest time needed.
Is Bijuva bioidentical hormone therapy?
Yes. Bijuva was the first FDA-approved single capsule to combine bio-identical estradiol and bio-identical progesterone. Because it is FDA-approved, it is tested for quality, dosing, and safety, unlike custom compounded bioidentical hormones.
Does Bijuva have a generic version?
No. There is currently no FDA-approved, substitutable generic for Bijuva's exact single-capsule estradiol/progesterone combination. Your provider may discuss taking generic estradiol and generic progesterone separately, or another approved hormone therapy, as a lower-cost option.
How much does Bijuva cost with a savings card?
The price depends on your pharmacy, location, and which savings tool you use. The manufacturer, Mayne Pharma, offers an official co-pay savings program that is generally limited to people with commercial insurance, and its terms vary. If you are uninsured, on Medicare, or the card is declined, the free Rx.com cash coupon on this page can lower your cost. Enter your ZIP above to see today's price.
What are the side effects of Bijuva?
Bijuva's label warns that estrogen-plus-progestin therapy may raise the risk of cardiovascular problems (stroke, blood clots, heart attack), invasive breast cancer, and probable dementia in women 65 and older. These appear in the label's Warnings and Precautions section. The label also lists a known anaphylactic reaction, angioedema, or hypersensitivity to Bijuva as a contraindication. Talk with your provider about your personal risks and any symptoms you notice.
How much does Bijuva cost without insurance?
The price of Bijuva without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 25% off retail prices with a free Rx.com coupon.
What are the common side effects of Bijuva?
Common side effects of Bijuva may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blurred or other changes in vision, Breast lumps or tenderness, Chest pain that may spread, coughing up blood, trouble breathing, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Bijuva?
Generic versions may be available for Bijuva. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Bijuva on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Bijuva?
The cheapest pharmacy for Bijuva depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Bijuva near you.

Bijuva Coupons & Prices

Bijuva 30 Capsules

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Bijuva 1 box (30 capsules), 1-100mg (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Bijuva coupon? Bijuva is a brand-name menopausal hormone therapy that combines bio-identical estradiol and progesterone in a single daily capsule to treat moderate-to-severe hot flashes in women who still have a uterus. It has no FDA-approved generic yet, so the price can run high at the pharmacy counter. The free Rx.com cash coupon on this page can lower what you pay whether or not you have insurance. Enter your ZIP above to see today's price at pharmacies near you.

What is Bijuva and how does it work?

Bijuva is FDA-approved to treat moderate-to-severe vasomotor symptoms (hot flashes) caused by menopause in women who have a uterus. It is the first FDA-approved single-capsule that pairs bio-identical estradiol with bio-identical progesterone. The estradiol relieves the hot flashes, while the progesterone protects the lining of the uterus and lowers the risk of endometrial (uterine) cancer that estrogen taken alone can cause.

Bijuva is meant to be used at the lowest dose that works, for the shortest time needed. The label advises that your provider re-evaluate treatment periodically to decide whether it is still needed. It is generally considered for women under 60 or within 10 years of the start of menopause. This is general information, not medical advice, so talk with your provider about whether Bijuva is right for you.

Bijuva cost: manufacturer savings card vs. Rx.com cash coupon

Two very different tools can lower your Bijuva cost, and it helps to know which one fits your situation. The manufacturer, Mayne Pharma, runs an official Bijuva co-pay savings program advertised on the brand's own website. Like most drugmaker co-pay cards, it is generally limited to people with commercial (private) insurance, and the exact terms and eligibility vary and can change, so read the fine print before you count on it. It typically cannot be used if you have Medicare, Medicaid, or other government coverage.

The Rx.com cash coupon on this page works differently. It is a cash-discount coupon, not insurance, so it can be used by people who are uninsured, paying cash, on Medicare, or in any case where the manufacturer card is declined. You do not choose between insurance and the coupon on the same purchase, but you can compare the coupon price to your plan's copay and use whichever is lower. Enter your ZIP above to see today's price at pharmacies near you.

Does Bijuva have a generic, and what are the alternatives?

There is currently no FDA-approved, substitutable generic for Bijuva's exact single-capsule estradiol/progesterone combination, so the brand price applies. If cost is a concern, ask your provider whether a different approach fits you. One common option is taking the two hormones separately, for example an estradiol product together with progesterone capsules, both of which are available as generics on their own.

Other FDA-approved menopausal hormone therapies your provider might discuss include Activella (estradiol/norethindrone), Prempro (conjugated estrogens/medroxyprogesterone), and estrogen-only products such as Estrace, Premarin, Divigel, and the Climara patch (estrogen-alone products require a separate progestin if you have a uterus). These differ in their hormones, forms, and dosing, so the right choice depends on your health history and preferences.

Safety, warnings, and who should not take Bijuva

Bijuva's prescribing information includes important warnings and precautions that apply to estrogen-plus-progestin therapy. Based on Women's Health Initiative data, estrogen plus progestin may increase the risk of cardiovascular problems (stroke, deep vein thrombosis, pulmonary embolism, and heart attack), invasive breast cancer, and probable dementia in postmenopausal women 65 and older. These risks are described in the label's Warnings and Precautions rather than as a boxed warning. Bijuva should be used at the lowest effective dose for the shortest time consistent with your treatment goals, and your provider should re-evaluate periodically whether you still need it.

Bijuva is not for women without a uterus. Do not use it if you have undiagnosed abnormal genital bleeding; a known, suspected, or past history of breast cancer; other estrogen-dependent cancers; active or past blood clots (DVT/PE) or arterial clot events (stroke, heart attack); liver disease; known clotting (thrombophilic) disorders such as protein C, protein S, or antithrombin deficiency; a known anaphylactic reaction, angioedema, or hypersensitivity to Bijuva; or known or suspected pregnancy. Unlike some standalone micronized progesterone capsules, Bijuva does not contain peanut oil. This is a summary, not a complete list; review the full label and your history with your provider.

Sources & accuracy

This Bijuva information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Bijuva on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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