Calcipotriene-Betameth Diprop
Calcipotriene-Betameth Diprop 60GM of 0.005-0.064%
What is Calcipotriene-Betameth Diprop?
Calcipotriene-Betamethasone Dipropionate is a combination topical medication used for the treatment of psoriasis. It merges calcipotriene, a vitamin D analogue that reduces skin cell production, with betamethasone dipropionate, a potent corticosteroid that alleviates inflammation and suppresses immune response. This dual-action cream or ointment is effective in improving psoriatic symptoms and is commonly prescribed for adults with plaque psoriasis.Side Effects
- Burning, pain, redness, or thinning of the skin
- Increased hunger, thirst, or urination
- Blurred vision or other change in vision, eye pain
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, Cushing syndrome, diabetes, eye or vision problems (including cataracts or glaucoma), any skin or scalp infection, or thin skin at the site to be treated.
- This medicine may cause the following problems:Adrenal gland problemsHigh blood sugarIncreased risk of cataracts or glaucomaEye or vision problemsAllergic contact dermatitis
- This medicine may cause calcium to build up in your body if you use too much of it. Too much calcium may increase your risk for adrenal gland problems.
- Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
Prescription savings · · · ·
What is Calcipotriene-Betameth Diprop ?
Calcipotriene-Betamethasone Dipropionate is a combination topical medication used for the treatment of psoriasis. It merges calcipotriene, a vitamin D analogue that reduces skin cell production, with betamethasone dipropionate, a potent corticosteroid that alleviates inflammation and suppresses immune response. This dual-action cream or ointment is effective in improving psoriatic symptoms and is commonly prescribed for adults with plaque psoriasis.- Burning, pain, redness, or thinning of the skin
- Increased hunger, thirst, or urination
- Blurred vision or other change in vision, eye pain
- Cold feeling, weakness, tiredness, nausea, vomiting, weight loss
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Severe itching or worsening of psoriasis
- Change of color or swelling of the skin where the medicine is applied, dark freckles, easy bruising, muscle weakness
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, Cushing syndrome, diabetes, eye or vision problems (including cataracts or glaucoma), any skin or scalp infection, or thin skin at the site to be treated.
- This medicine may cause the following problems:Adrenal gland problemsHigh blood sugarIncreased risk of cataracts or glaucomaEye or vision problemsAllergic contact dermatitis
- This medicine may cause calcium to build up in your body if you use too much of it. Too much calcium may increase your risk for adrenal gland problems.
- Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Call your doctor if your symptoms do not improve or if they get worse.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
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Calcipotriene and betamethasone dipropionate is a combination topical medicine for plaque psoriasis, and if you're comparing a calcipotriene-betameth-diprop coupon against other savings sites, the most useful thing to know is that this combination is already available as a generic (for the ointment and topical suspension formulations) and that the price for that generic can still vary widely from one pharmacy to the next. Rx.com compares pricing across 60,000+ pharmacies so you can find where it's lowest near you — enter your ZIP above to see today's price.
What is calcipotriene and betamethasone dipropionate?
This medicine combines two active ingredients in one topical product: calcipotriene, a vitamin D analog, and betamethasone dipropionate, a high-potency topical corticosteroid. Together they're FDA-approved to treat plaque psoriasis on the skin. It's sold under a few brand names — Taclonex (ointment and topical suspension, now widely available as a generic), Enstilar (an aerosol foam approved for patients 12 and older), and Wynzora (a newer cream formulation approved for adults 18 and older).
Depending on the formulation, it's applied once daily to the affected skin, generally for a limited course of several weeks before your provider reassesses your skin. It's approved specifically for plaque psoriasis — not for other skin conditions — though a provider may occasionally use it short-term, off-label, for other steroid- and vitamin-D-responsive scaling patches.
Cost and how to save on calcipotriene/betamethasone
Because a generic version of the ointment and topical suspension is now widely available, this combination is a lower-cost option compared to filling a brand-only product — but the cash price for the same generic can still swing noticeably between pharmacies in the same town, which is exactly what a pharmacy comparison tool like Rx.com is built to catch. Enstilar foam and Wynzora cream are newer branded formulations, so if your prescription is written for one of those, pricing works differently than for the generic ointment/suspension.
If cost is a concern, ask your provider or pharmacist whether the generic ointment or suspension is appropriate for your situation, since it's typically the most price-competitive option. The manufacturer of Enstilar and Taclonex, LEO Pharma, also offers a co-pay savings program through its official patient site for eligible commercially-insured patients — terms, eligibility, and savings amounts vary and are set by the manufacturer, so check directly with them for current details. Either way, enter your ZIP above to compare pharmacy prices near you before you fill.
Taclonex vs. Enstilar vs. Wynzora, and other options
All three brand names contain the same two active ingredients, but the formulation changes how and where you use them. Taclonex ointment and topical suspension are the original formulations (suspension for the scalp, ointment for the body) and are the versions with a generic now on the market. Enstilar is an aerosol foam approved for patients 12 and older. Wynzora is a newer cream-based formulation approved for adults. Your provider chooses the formulation based on where the psoriasis is and what's easiest for you to apply consistently.
If this combination isn't the right fit, other topical options your provider might consider include calcipotriene alone, betamethasone dipropionate alone, or another high-potency topical steroid such as clobetasol propionate or triamcinolone acetonide. For more extensive or harder-to-control plaque psoriasis, a provider may move to a systemic option such as methotrexate instead of a topical.
Safety information
As a topical corticosteroid, betamethasone dipropionate can cause local skin thinning, stretch marks, or visible small blood vessels with prolonged use, and using it over large areas, under wraps, or for too long can lead to whole-body steroid absorption, reversible suppression of the body's normal cortisol response, and rarely high blood sugar or Cushing's syndrome. The calcipotriene component carries a separate risk of elevated calcium levels in the blood or urine, particularly if you use more than your product's labeled weekly amount — check your specific product's label or ask your pharmacist what that limit is for your formulation.
- Do not apply to the face, groin, underarms, or under a bandage/wrap, and avoid getting it in your eyes.
- If you're using Enstilar foam, it's flammable — stay away from open flame or lit cigarettes until it's dried on your skin.
- Not for use in the eyes, mouth, or vagina.
- The most common side effects are irritation, itching, or burning where it's applied.
This product does not carry an FDA boxed warning. This isn't a complete list of risks — talk with your doctor or pharmacist about whether it's right for you and how long to use it.
This Calcipotriene-Betameth Diprop information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Calcipotriene-Betameth Diprop on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.